SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iby'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 3iby FERROUS IRON
TRANSPORT PROTEIN B
(Legionella
pneumophila) 		5 / 10 LEU A  17
ILE A 154
LEU A  45
LEU A 161
VAL A 114
 None
 1.02A 1cqpA-3ibyA:
2.4
1cqpB-3ibyA:
3.9		 1cqpA-3ibyA:
24.91
1cqpB-3ibyA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 3iby FERROUS IRON
TRANSPORT PROTEIN B
(Legionella
pneumophila) 		4 / 7 VAL A 114
LEU A  17
LEU A  45
LEU A 161
 None
 0.72A 1cqpA-3ibyA:
3.3
1cqpB-3ibyA:
3.9		 1cqpA-3ibyA:
24.91
1cqpB-3ibyA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3iby FERROUS IRON
TRANSPORT PROTEIN B
(Legionella
pneumophila) 		6 / 12 LEU A 106
PHE A 107
SER A 104
ILE A  91
LEU A 100
CYH A 141
 None
 1.50A 2oipD-3ibyA:
undetectable		 2oipD-3ibyA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 3iby FERROUS IRON
TRANSPORT PROTEIN B
(Legionella
pneumophila) 		5 / 12 ALA A  20
ILE A 154
LEU A 161
ILE A  52
THR A  16
 None
 1.12A 2w3vA-3ibyA:
undetectable		 2w3vA-3ibyA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3iby FERROUS IRON
TRANSPORT PROTEIN B
(Legionella
pneumophila) 		4 / 6 LEU A 100
ILE A  91
ILE A  52
LEU A  55
 None
 0.94A 2xkwB-3ibyA:
undetectable		 2xkwB-3ibyA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 3iby FERROUS IRON
TRANSPORT PROTEIN B
(Legionella
pneumophila) 		5 / 12 ILE A 154
ILE A 146
MET A 120
ILE A  52
VAL A 114
 None
 1.07A 2ygoA-3ibyA:
undetectable		 2ygoA-3ibyA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 3iby FERROUS IRON
TRANSPORT PROTEIN B
(Legionella
pneumophila) 		5 / 12 THR A  22
ILE A 154
LEU A  17
ILE A  88
ALA A 116
 None
 1.12A 3a50A-3ibyA:
undetectable		 3a50A-3ibyA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 3iby FERROUS IRON
TRANSPORT PROTEIN B
(Legionella
pneumophila) 		5 / 12 GLN A 228
LEU A 234
SER A 176
GLN A 181
LEU A 186
 None
 1.43A 3fsuA-3ibyA:
undetectable		 3fsuA-3ibyA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 3iby FERROUS IRON
TRANSPORT PROTEIN B
(Legionella
pneumophila) 		4 / 7 ARG A  98
VAL A 113
LEU A 117
ILE A  87
 None
 0.84A 3gp0A-3ibyA:
undetectable		 3gp0A-3ibyA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 3iby FERROUS IRON
TRANSPORT PROTEIN B
(Legionella
pneumophila) 		5 / 9 LEU A 139
LEU A 100
ILE A   7
PHE A 107
VAL A 113
 None
 1.26A 3tmzA-3ibyA:
undetectable		 3tmzA-3ibyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3iby FERROUS IRON
TRANSPORT PROTEIN B
(Legionella
pneumophila) 		5 / 9 TYR A 201
ILE A 182
GLU A 209
LEU A 173
LEU A 175
 None
 1.48A 4l1xB-3ibyA:
undetectable		 4l1xB-3ibyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3iby FERROUS IRON
TRANSPORT PROTEIN B
(Legionella
pneumophila) 		4 / 7 LEU A 186
LEU A 190
GLU A 209
LEU A 207
 None
 0.82A 4wg0L-3ibyA:
undetectable
4wg0M-3ibyA:
undetectable		 4wg0L-3ibyA:
8.33
4wg0M-3ibyA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 3iby FERROUS IRON
TRANSPORT PROTEIN B
(Legionella
pneumophila) 		5 / 10 ASN A   9
ASP A  92
ALA A 123
ILE A 130
LEU A 117
 None
 1.21A 4xj7A-3ibyA:
4.0
4xj7B-3ibyA:
4.5		 4xj7A-3ibyA:
23.08
4xj7B-3ibyA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3iby FERROUS IRON
TRANSPORT PROTEIN B
(Legionella
pneumophila) 		5 / 12 VAL A 250
ILE A 168
ILE A  91
VAL A 143
VAL A 113
 None
 1.10A 5mugA-3ibyA:
undetectable		 5mugA-3ibyA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 3iby FERROUS IRON
TRANSPORT PROTEIN B
(Legionella
pneumophila) 		4 / 5 ILE A  50
THR A   2
THR A  22
LEU A   6
 None
 1.09A 6f3mD-3ibyA:
2.2		 6f3mD-3ibyA:
20.22