SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ic1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 3ic1 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		3 / 3 ASP A  22
LEU A  51
LEU A  49
 None
 0.73A 1ikeA-3ic1A:
undetectable		 1ikeA-3ic1A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3ic1 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		4 / 6 ALA A 112
LEU A 105
GLU A 113
LEU A  51
 None
 1.00A 1mt1D-3ic1A:
undetectable
1mt1E-3ic1A:
undetectable		 1mt1D-3ic1A:
15.83
1mt1E-3ic1A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 3ic1 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		3 / 3 ASP A  22
LEU A  51
LEU A  49
 None
 0.69A 1np1B-3ic1A:
undetectable		 1np1B-3ic1A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 3ic1 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		5 / 10 ILE A  88
LEU A  12
LEU A  93
GLY A 103
ALA A 106
 None
 1.24A 2xf3A-3ic1A:
undetectable		 2xf3A-3ic1A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3ic1 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		4 / 5 SER A 231
ARG A 258
PRO A 293
GLY A 180
 None
SO4  A 378 (-2.9A)
None
None
 1.42A 2y7kB-3ic1A:
undetectable		 2y7kB-3ic1A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3ic1 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		5 / 12 ASN A  50
GLY A 141
ASP A 140
LEU A 333
MET A 150
 None
 1.09A 2zw9A-3ic1A:
undetectable		 2zw9A-3ic1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3ic1 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		4 / 6 LEU A  33
PHE A  38
ILE A 126
ALA A 127
 None
 0.81A 3mdrA-3ic1A:
undetectable		 3mdrA-3ic1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3ic1 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		4 / 7 ALA A 127
ILE A 126
HIS A 122
GLY A  56
 None
 0.84A 3v4tH-3ic1A:
undetectable		 3v4tH-3ic1A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 3ic1 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		4 / 6 GLY A 299
LEU A 374
TYR A 158
GLU A 337
 SO4  A 379 (-3.3A)
None
None
SO4  A 379 ( 4.2A)
 1.16A 3w9tE-3ic1A:
undetectable		 3w9tE-3ic1A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 3ic1 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		4 / 7 LYS A  54
THR A 125
ALA A 127
LEU A 129
 None
 0.88A 4d7bA-3ic1A:
undetectable		 4d7bA-3ic1A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 3ic1 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		4 / 7 ASP A 100
GLU A 135
HIS A 349
GLU A 134
 ZN  A1001 ( 2.4A)
ZN  A1002 ( 1.7A)
ZN  A1002 (-3.4A)
ZN  A1001 (-3.9A)
 0.94A 4hvrA-3ic1A:
undetectable		 4hvrA-3ic1A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 3ic1 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		5 / 12 LYS A 102
ALA A 111
GLU A 113
LEU A   8
LEU A 128
 None
 1.19A 4i1rA-3ic1A:
2.0		 4i1rA-3ic1A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 3ic1 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		4 / 8 LYS A  54
THR A 125
ALA A 127
LEU A 129
 None
 0.80A 4iizB-3ic1A:
undetectable		 4iizB-3ic1A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 3ic1 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		4 / 8 LYS A  54
THR A 125
ALA A 127
VAL A  61
 None
 0.70A 4iizB-3ic1A:
undetectable		 4iizB-3ic1A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 3ic1 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		4 / 8 LYS A  54
THR A 125
ALA A 127
LEU A 129
 None
 0.85A 4ik6B-3ic1A:
undetectable		 4ik6B-3ic1A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 3ic1 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		4 / 8 LYS A  54
THR A 125
ALA A 127
VAL A  61
 None
 0.74A 4ik6B-3ic1A:
undetectable		 4ik6B-3ic1A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 3ic1 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		5 / 12 ILE A 366
GLY A 162
GLY A 342
ALA A  65
MET A 108
 None
 1.11A 4kicB-3ic1A:
undetectable		 4kicB-3ic1A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 3ic1 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		5 / 10 PRO A 293
GLY A 328
PHE A 294
SER A 290
GLY A 291
 None
 1.27A 4mmdA-3ic1A:
undetectable		 4mmdA-3ic1A:
21.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 3ic1 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		8 / 11 HIS A  67
ASP A 100
GLU A 134
GLU A 135
GLU A 163
GLY A 323
ASN A 345
ILE A 348
 ZN  A1001 (-3.3A)
ZN  A1001 ( 2.4A)
ZN  A1001 (-3.9A)
ZN  A1002 ( 1.7A)
ZN  A1001 (-2.0A)
SO4  A 378 (-3.9A)
None
None
 0.85A 4pqaA-3ic1A:
49.3		 4pqaA-3ic1A:
54.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 3ic1 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE
(Haemophilus
influenzae) 		10 / 11 HIS A  67
ASP A 100
GLU A 134
GLU A 135
GLU A 163
GLY A 323
GLY A 324
ASN A 345
ILE A 348
HIS A 349
 ZN  A1001 (-3.3A)
ZN  A1001 ( 2.4A)
ZN  A1001 (-3.9A)
ZN  A1002 ( 1.7A)
ZN  A1001 (-2.0A)
SO4  A 378 (-3.9A)
SO4  A 378 (-3.3A)
None
None
ZN  A1002 (-3.4A)
 0.64A 4pqaA-3ic1A:
49.3		 4pqaA-3ic1A:
54.50