SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ic5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE
(Ruegeria
pomeroyi) 		5 / 12 ILE A  82
ALA A  85
ALA A  86
LEU A  60
ALA A  61
 None
 0.82A 1fbyA-3ic5A:
undetectable		 1fbyA-3ic5A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE
(Ruegeria
pomeroyi) 		5 / 12 ILE A  82
ALA A  85
ALA A  86
LEU A  60
ALA A  61
 None
 0.82A 1fbyB-3ic5A:
undetectable		 1fbyB-3ic5A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE
(Ruegeria
pomeroyi) 		5 / 12 ILE A  82
ALA A  85
ALA A  86
LEU A  60
ALA A  61
 None
 0.79A 1fm6A-3ic5A:
undetectable		 1fm6A-3ic5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE
(Ruegeria
pomeroyi) 		5 / 12 ILE A  82
ALA A  85
ALA A  86
LEU A  60
ALA A  61
 None
 0.82A 1fm9A-3ic5A:
undetectable		 1fm9A-3ic5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE
(Ruegeria
pomeroyi) 		5 / 11 LEU A  42
PHE A  77
ALA A  74
VAL A  31
GLN A  15
 None
 1.35A 1hbpA-3ic5A:
undetectable		 1hbpA-3ic5A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE
(Ruegeria
pomeroyi) 		5 / 12 ILE A  82
ALA A  85
ALA A  86
LEU A  60
ALA A  61
 None
 0.79A 1k74A-3ic5A:
undetectable		 1k74A-3ic5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE
(Ruegeria
pomeroyi) 		5 / 12 ILE A  82
ALA A  85
ALA A  86
LEU A  60
ALA A  61
 None
 0.80A 1xdkE-3ic5A:
undetectable		 1xdkE-3ic5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE
(Ruegeria
pomeroyi) 		5 / 12 ILE A  82
ALA A  85
ALA A  86
LEU A  60
ALA A  61
 None
 0.83A 1xiuA-3ic5A:
undetectable		 1xiuA-3ic5A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE
(Ruegeria
pomeroyi) 		5 / 12 ILE A  82
ALA A  85
ALA A  86
LEU A  60
ALA A  61
 None
 0.82A 1xlsA-3ic5A:
undetectable		 1xlsA-3ic5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE
(Ruegeria
pomeroyi) 		5 / 12 ILE A  82
ALA A  85
ALA A  86
LEU A  60
ALA A  61
 None
 0.83A 1xlsB-3ic5A:
undetectable		 1xlsB-3ic5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE
(Ruegeria
pomeroyi) 		5 / 12 ILE A  82
ALA A  85
ALA A  86
LEU A  60
ALA A  61
 None
 0.83A 1xlsC-3ic5A:
undetectable		 1xlsC-3ic5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE
(Ruegeria
pomeroyi) 		5 / 12 ILE A  82
ALA A  85
ALA A  86
LEU A  60
ALA A  61
 None
 0.82A 1xlsD-3ic5A:
undetectable		 1xlsD-3ic5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE
(Ruegeria
pomeroyi) 		5 / 12 ILE A  82
ALA A  85
ALA A  86
LEU A  60
ALA A  61
 None
 0.83A 2aclG-3ic5A:
undetectable		 2aclG-3ic5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE
(Ruegeria
pomeroyi) 		5 / 10 ILE A  82
ALA A  85
ALA A  86
LEU A  60
ALA A  61
 None
 0.78A 3falC-3ic5A:
undetectable		 3falC-3ic5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE
(Ruegeria
pomeroyi) 		5 / 11 ILE A  82
ALA A  85
ALA A  86
LEU A  60
ALA A  61
 None
 0.75A 3fc6A-3ic5A:
undetectable		 3fc6A-3ic5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE
(Ruegeria
pomeroyi) 		5 / 12 ILE A  82
ALA A  85
ALA A  86
LEU A  60
ALA A  61
 None
 0.85A 3oapA-3ic5A:
undetectable		 3oapA-3ic5A:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE
(Ruegeria
pomeroyi) 		5 / 12 ILE A  82
ALA A  85
ALA A  86
LEU A  60
ALA A  61
 None
 0.71A 4k6iA-3ic5A:
undetectable		 4k6iA-3ic5A:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE
(Ruegeria
pomeroyi) 		4 / 7 CYH A   6
ILE A  71
HIS A  92
ALA A  86
 None
 0.98A 5hrqE-3ic5A:
undetectable
5hrqF-3ic5A:
undetectable
5hrqJ-3ic5A:
undetectable		 5hrqE-3ic5A:
7.48
5hrqF-3ic5A:
14.41
5hrqJ-3ic5A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE
(Ruegeria
pomeroyi) 		5 / 12 ILE A  82
ALA A  85
ALA A  86
LEU A  60
ALA A  61
 None
 0.73A 5uanA-3ic5A:
undetectable		 5uanA-3ic5A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE
(Ruegeria
pomeroyi) 		3 / 3 GLY A  11
VAL A  47
MET A  45
 None
 0.52A 5ycpA-3ic5A:
undetectable		 5ycpA-3ic5A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE
(Ruegeria
pomeroyi) 		5 / 12 ILE A  82
ALA A  85
ALA A  86
LEU A  60
ALA A  61
 None
 0.84A 5z12B-3ic5A:
undetectable		 5z12B-3ic5A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE
(Ruegeria
pomeroyi) 		5 / 12 ILE A  82
ALA A  85
ALA A  86
LEU A  60
ALA A  61
 None
 0.88A 5z12C-3ic5A:
undetectable		 5z12C-3ic5A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE
(Ruegeria
pomeroyi) 		5 / 12 ILE A  82
ALA A  85
ALA A  86
LEU A  60
ALA A  61
 None
 0.89A 6a5zL-3ic5A:
undetectable		 6a5zL-3ic5A:
21.19