SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ic6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 3ic6 PUTATIVE METHYLASE
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		6 / 12 PHE A 144
GLY A 145
GLY A 150
ILE A 165
LEU A 174
ALA A 179
 None
 0.55A 1v2xA-3ic6A:
14.8		 1v2xA-3ic6A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 3ic6 PUTATIVE METHYLASE
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		5 / 11 GLY A 145
GLY A 150
ILE A 165
LEU A 174
ALA A 179
 None
 0.76A 1x7pA-3ic6A:
15.3
1x7pB-3ic6A:
15.1		 1x7pA-3ic6A:
22.01
1x7pB-3ic6A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ic6 PUTATIVE METHYLASE
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		5 / 10 ILE A  28
ALA A  31
ALA A  32
ASN A  89
ILE A  92
 None
 1.05A 2aclC-3ic6A:
undetectable		 2aclC-3ic6A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ic6 PUTATIVE METHYLASE
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		5 / 11 ILE A  28
ALA A  31
ALA A  32
ASN A  89
ILE A  92
 None
 1.06A 2aclE-3ic6A:
undetectable		 2aclE-3ic6A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 3ic6 PUTATIVE METHYLASE
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		4 / 9 ILE A  17
ALA A 177
VAL A 180
CYH A 184
 None
 0.88A 2vufB-3ic6A:
undetectable		 2vufB-3ic6A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 3ic6 PUTATIVE METHYLASE
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		5 / 11 GLY A 145
GLY A 150
ILE A 165
LEU A 174
ALA A 179
 None
 0.74A 3dcmX-3ic6A:
13.2		 3dcmX-3ic6A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ic6 PUTATIVE METHYLASE
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 ILE A  28
ALA A  31
ALA A  32
ASN A  89
ILE A  92
 None
 1.04A 3e00A-3ic6A:
undetectable		 3e00A-3ic6A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 3ic6 PUTATIVE METHYLASE
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 ASN A  27
LEU A 109
GLY A 145
GLY A 150
ILE A 165
 None
 0.93A 3nk7A-3ic6A:
14.1		 3nk7A-3ic6A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 3ic6 PUTATIVE METHYLASE
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		6 / 12 ASN A  27
LEU A 109
PHE A 144
GLY A 145
GLY A 150
ILE A 165
 None
 0.88A 3nk7B-3ic6A:
14.0		 3nk7B-3ic6A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 3ic6 PUTATIVE METHYLASE
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		6 / 12 ASN A  27
PHE A 144
GLY A 145
GLY A 150
ILE A 165
LEU A 174
 None
 0.72A 3nk7B-3ic6A:
14.0		 3nk7B-3ic6A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ic6 PUTATIVE METHYLASE
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 ILE A  28
ALA A  32
ALA A  31
ALA A  83
LEU A 176
 None
 1.20A 3uvvB-3ic6A:
undetectable		 3uvvB-3ic6A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3ic6 PUTATIVE METHYLASE
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		4 / 5 LEU A 176
GLY A 145
ILE A  45
VAL A  46
 None
 0.91A 3wriA-3ic6A:
undetectable		 3wriA-3ic6A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 3ic6 PUTATIVE METHYLASE
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		4 / 5 LEU A 176
GLY A 145
ILE A  45
VAL A  46
 None
 0.91A 3wriB-3ic6A:
undetectable		 3wriB-3ic6A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3ic6 PUTATIVE METHYLASE
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 GLY A 145
GLY A 150
THR A  20
ILE A  45
LEU A  43
 None
 1.14A 4n48A-3ic6A:
undetectable		 4n48A-3ic6A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3ic6 PUTATIVE METHYLASE
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 GLY A 145
GLY A 150
THR A  20
ILE A  45
LEU A  43
 None
 1.14A 4n48B-3ic6A:
undetectable		 4n48B-3ic6A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 3ic6 PUTATIVE METHYLASE
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		6 / 12 GLY A 145
GLY A 150
ILE A 165
LEU A 174
LEU A 176
ALA A 179
 None
 0.60A 5l0zA-3ic6A:
15.4		 5l0zA-3ic6A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 3ic6 PUTATIVE METHYLASE
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		6 / 10 GLY A 145
GLY A 150
ILE A 165
LEU A 174
LEU A 176
ALA A 179
 None
 0.62A 5l0zB-3ic6A:
14.4		 5l0zB-3ic6A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3ic6 PUTATIVE METHYLASE
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 VAL A  93
GLU A  91
LEU A 151
LEU A  96
ALA A  99
 None
 1.18A 5nd3B-3ic6A:
undetectable		 5nd3B-3ic6A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3ic6 PUTATIVE METHYLASE
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 VAL A  93
GLU A  91
LEU A 151
LEU A  96
ALA A  99
 None
 0.94A 5nd7B-3ic6A:
undetectable		 5nd7B-3ic6A:
20.22