SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ic9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		4 / 8 GLN A 210
ASN A 208
LEU A 209
LEU A 317
 None
None
None
FAD  A 490 (-4.2A)
 0.99A 1hk2A-3ic9A:
3.7		 1hk2A-3ic9A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		5 / 11 PRO A 171
LEU A 190
VAL A 176
GLY A 183
LEU A  54
 None
 1.17A 1lwcA-3ic9A:
undetectable		 1lwcA-3ic9A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		5 / 12 GLN A 388
ALA A 422
GLY A 399
SER A 391
LEU A 400
 None
 1.04A 1rjdA-3ic9A:
undetectable		 1rjdA-3ic9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		5 / 12 GLN A 388
ALA A 422
GLY A 399
SER A 391
LEU A 400
 None
 1.01A 1rjdB-3ic9A:
undetectable		 1rjdB-3ic9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		5 / 12 GLN A 388
ALA A 422
GLY A 399
SER A 391
LEU A 400
 None
 1.00A 1rjdC-3ic9A:
undetectable		 1rjdC-3ic9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		5 / 12 ALA A 154
LEU A 151
ASN A 161
LEU A 164
VAL A 174
 None
None
FAD  A 490 (-3.7A)
None
None
 1.30A 1u72A-3ic9A:
undetectable		 1u72A-3ic9A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		4 / 8 THR A 141
GLY A  14
THR A  15
ALA A  16
 FAD  A 490 (-4.0A)
FAD  A 490 (-3.2A)
FAD  A 490 (-4.4A)
FAD  A 490 (-3.6A)
 0.85A 2a1hA-3ic9A:
undetectable
2a1hB-3ic9A:
undetectable		 2a1hA-3ic9A:
23.00
2a1hB-3ic9A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		5 / 12 LEU A 276
GLU A  35
GLY A  12
ALA A 140
ALA A 308
 None
FAD  A 490 (-2.8A)
FAD  A 490 (-3.1A)
None
None
 1.00A 2br4F-3ic9A:
undetectable		 2br4F-3ic9A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		6 / 10 ALA A  60
ALA A  57
LEU A  54
LEU A 193
ALA A 189
SER A  65
 None
 1.34A 2bxgB-3ic9A:
3.4		 2bxgB-3ic9A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		4 / 6 VAL A 273
THR A 316
SER A 143
ASP A 310
 None
None
None
FAD  A 490 (-3.0A)
 1.30A 2hdnJ-3ic9A:
undetectable
2hdnK-3ic9A:
undetectable
2hdnL-3ic9A:
undetectable		 2hdnJ-3ic9A:
21.60
2hdnK-3ic9A:
6.18
2hdnL-3ic9A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_1
(PROTEASE)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		6 / 12 ARG A 344
ASP A 324
GLY A 309
ALA A 308
ILE A  10
GLY A  14
 None
NA  A 491 (-3.0A)
FAD  A 490 ( 3.3A)
None
None
FAD  A 490 (-3.2A)
 1.34A 2nmyA-3ic9A:
undetectable		 2nmyA-3ic9A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		5 / 12 GLY A  14
GLY A 142
ALA A 311
VAL A  99
MET A  18
 FAD  A 490 (-3.2A)
FAD  A 490 (-3.3A)
None
None
None
 0.87A 2nyuA-3ic9A:
undetectable		 2nyuA-3ic9A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		4 / 6 LEU A 428
SER A 391
PHE A 385
GLU A 453
 None
 1.30A 2vn1B-3ic9A:
undetectable		 2vn1B-3ic9A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		3 / 3 TYR A  62
GLU A 353
ASN A 397
 None
 1.02A 2y7hC-3ic9A:
2.5		 2y7hC-3ic9A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		5 / 12 ALA A 463
THR A 438
PHE A 447
GLY A 414
LEU A 401
 None
 1.46A 3aodC-3ic9A:
undetectable		 3aodC-3ic9A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		6 / 11 ARG A 344
ASP A 324
GLY A 309
ALA A 308
ILE A  10
GLY A  14
 None
NA  A 491 (-3.0A)
FAD  A 490 ( 3.3A)
None
None
FAD  A 490 (-3.2A)
 1.32A 3ndxB-3ic9A:
undetectable		 3ndxB-3ic9A:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		5 / 12 ALA A   9
ILE A  34
PHE A 118
THR A 141
ILE A 139
 None
FAD  A 490 ( 4.8A)
None
FAD  A 490 (-4.0A)
None
 1.16A 3qfxB-3ic9A:
undetectable		 3qfxB-3ic9A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		3 / 3 ASN A 312
LEU A 276
PHE A 306
 NA  A 491 (-2.6A)
None
None
 0.78A 4dajB-3ic9A:
undetectable		 4dajB-3ic9A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		4 / 6 LEU A  54
LYS A  52
LEU A 186
GLU A 185
 None
FAD  A 490 (-3.1A)
None
None
 1.06A 4f3tA-3ic9A:
undetectable		 4f3tA-3ic9A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		4 / 8 ASP A 324
ASN A 312
GLU A 295
ASP A 310
 NA  A 491 (-3.0A)
NA  A 491 (-2.6A)
None
FAD  A 490 (-3.0A)
 0.96A 4feuD-3ic9A:
undetectable		 4feuD-3ic9A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		4 / 7 ASP A 324
ASN A 312
GLU A 295
ASP A 310
 NA  A 491 (-3.0A)
NA  A 491 (-2.6A)
None
FAD  A 490 (-3.0A)
 1.00A 4fevB-3ic9A:
undetectable		 4fevB-3ic9A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		4 / 8 ASP A 324
ASN A 312
GLU A 295
ASP A 310
 NA  A 491 (-3.0A)
NA  A 491 (-2.6A)
None
FAD  A 490 (-3.0A)
 1.02A 4gkhD-3ic9A:
undetectable		 4gkhD-3ic9A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		5 / 9 ASP A 324
ARG A 269
ASN A 312
GLU A 295
ASP A 310
 NA  A 491 (-3.0A)
FAD  A 490 ( 3.9A)
NA  A 491 (-2.6A)
None
FAD  A 490 (-3.0A)
 1.10A 4gkiF-3ic9A:
0.0		 4gkiF-3ic9A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		4 / 7 ALA A  60
SER A  61
VAL A  84
ARG A  87
 None
 0.77A 4ijiH-3ic9A:
undetectable		 4ijiH-3ic9A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		5 / 12 GLY A  36
ARG A  45
ILE A  11
ALA A 116
ALA A 140
 FAD  A 490 (-4.0A)
None
FAD  A 490 (-4.8A)
FAD  A 490 (-4.1A)
None
 1.15A 4kicA-3ic9A:
2.7		 4kicA-3ic9A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		5 / 11 GLN A 373
GLY A 410
TYR A 404
ALA A 463
LYS A 466
 None
 1.14A 4rv6A-3ic9A:
undetectable		 4rv6A-3ic9A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		5 / 11 GLN A 373
GLY A 410
TYR A 404
ALA A 463
LYS A 466
 None
 1.14A 4rv6B-3ic9A:
undetectable		 4rv6B-3ic9A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		4 / 4 GLY A  37
LEU A 276
PHE A 118
ILE A  11
 FAD  A 490 ( 4.2A)
None
None
FAD  A 490 (-4.8A)
 0.81A 4xv2A-3ic9A:
undetectable		 4xv2A-3ic9A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		5 / 12 LEU A 170
VAL A  84
ILE A  88
LEU A 159
LEU A 164
 None
 1.32A 4yvpB-3ic9A:
undetectable		 4yvpB-3ic9A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		4 / 7 ILE A  10
GLU A  35
GLY A  14
GLY A  17
 None
FAD  A 490 (-2.8A)
FAD  A 490 (-3.2A)
None
 0.81A 5a06A-3ic9A:
undetectable		 5a06A-3ic9A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		4 / 7 ILE A  10
GLU A  35
GLY A  14
GLY A  17
 None
FAD  A 490 (-2.8A)
FAD  A 490 (-3.2A)
None
 0.83A 5a06B-3ic9A:
undetectable		 5a06B-3ic9A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		4 / 7 ILE A  10
GLU A  35
GLY A  14
GLY A  17
 None
FAD  A 490 (-2.8A)
FAD  A 490 (-3.2A)
None
 0.79A 5a06C-3ic9A:
undetectable		 5a06C-3ic9A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		4 / 7 ILE A  10
GLU A  35
GLY A  14
GLY A  17
 None
FAD  A 490 (-2.8A)
FAD  A 490 (-3.2A)
None
 0.81A 5a06E-3ic9A:
undetectable		 5a06E-3ic9A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		4 / 7 ILE A  10
GLU A  35
GLY A  14
GLY A  17
 None
FAD  A 490 (-2.8A)
FAD  A 490 (-3.2A)
None
 0.81A 5a06F-3ic9A:
undetectable		 5a06F-3ic9A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		5 / 12 LEU A 184
GLY A 178
SER A 143
ASN A 208
VAL A 350
 None
 1.15A 5d0yA-3ic9A:
undetectable		 5d0yA-3ic9A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		3 / 3 ASN A 312
LEU A 276
PHE A 306
 NA  A 491 (-2.6A)
None
None
 0.71A 5dsgA-3ic9A:
undetectable		 5dsgA-3ic9A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		3 / 3 ASN A 312
LEU A 278
PHE A 306
 NA  A 491 (-2.6A)
None
None
 0.78A 5dsgA-3ic9A:
undetectable		 5dsgA-3ic9A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		5 / 12 GLY A 325
GLY A  12
GLY A  14
GLY A  19
ILE A  11
 None
FAD  A 490 (-3.1A)
FAD  A 490 (-3.2A)
None
FAD  A 490 (-4.8A)
 1.02A 5ekxA-3ic9A:
undetectable		 5ekxA-3ic9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		5 / 11 PRO A 171
LEU A 190
VAL A 176
GLY A 183
LEU A  54
 None
 1.08A 5hbmA-3ic9A:
undetectable		 5hbmA-3ic9A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		4 / 8 ALA A 308
VAL A 138
THR A  13
GLY A 329
 None
 1.00A 5v0vA-3ic9A:
3.8		 5v0vA-3ic9A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		4 / 8 LEU A 190
VAL A 195
VAL A 174
ASP A 169
 None
 0.64A 5y9mA-3ic9A:
undetectable		 5y9mA-3ic9A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		4 / 8 LEU A 190
VAL A 195
VAL A 174
ASP A 169
 None
 0.65A 5y9mX-3ic9A:
undetectable		 5y9mX-3ic9A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_2
(RIFAMPIN
MONOOXYGENASE)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		4 / 4 GLN A 188
VAL A 176
ARG A  87
ARG A 192
 None
 1.44A 6brdA-3ic9A:
11.1		 6brdA-3ic9A:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		5 / 10 GLY A  12
GLY A  14
GLU A  35
THR A 141
ASN A 272
 FAD  A 490 (-3.1A)
FAD  A 490 (-3.2A)
FAD  A 490 (-2.8A)
FAD  A 490 (-4.0A)
FAD  A 490 ( 4.9A)
 0.77A 6exiA-3ic9A:
undetectable		 6exiA-3ic9A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		5 / 10 GLY A  12
GLY A  14
GLU A  35
THR A 141
ASN A 272
 FAD  A 490 (-3.1A)
FAD  A 490 (-3.2A)
FAD  A 490 (-2.8A)
FAD  A 490 (-4.0A)
FAD  A 490 ( 4.9A)
 0.80A 6exiB-3ic9A:
undetectable		 6exiB-3ic9A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		5 / 12 GLY A  12
GLY A  14
GLU A  35
THR A 141
ASN A 272
 FAD  A 490 (-3.1A)
FAD  A 490 (-3.2A)
FAD  A 490 (-2.8A)
FAD  A 490 (-4.0A)
FAD  A 490 ( 4.9A)
 0.80A 6exiC-3ic9A:
2.3
6exiD-3ic9A:
2.2		 6exiC-3ic9A:
15.12
6exiD-3ic9A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		5 / 12 GLY A  12
GLY A  14
GLU A  35
THR A 141
ASN A 272
 FAD  A 490 (-3.1A)
FAD  A 490 (-3.2A)
FAD  A 490 (-2.8A)
FAD  A 490 (-4.0A)
FAD  A 490 ( 4.9A)
 0.78A 6exiC-3ic9A:
2.3
6exiD-3ic9A:
2.2		 6exiC-3ic9A:
15.12
6exiD-3ic9A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		5 / 10 PHE A 351
ILE A  55
LEU A 170
LEU A 186
GLY A 187
 FAD  A 490 (-4.8A)
None
None
None
None
 1.42A 6r2eC-3ic9A:
undetectable		 6r2eC-3ic9A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Colwellia
psychrerythraea) 		5 / 12 PHE A 351
ILE A  55
LEU A 170
LEU A 186
GLY A 187
 FAD  A 490 (-4.8A)
None
None
None
None
 1.26A 6r2eH-3ic9A:
undetectable		 6r2eH-3ic9A:
22.36