SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ica'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 3ica PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Porphyromonas
gingivalis) 		5 / 12 LEU A 112
GLY A 180
TYR A 165
ILE A 114
VAL A 141
 None
 1.31A 1tmxB-3icaA:
undetectable		 1tmxB-3icaA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3ica PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Porphyromonas
gingivalis) 		4 / 6 LEU A  63
ASN A  73
GLN A 197
PHE A 201
 None
GOL  A 214 ( 4.8A)
None
None
 1.23A 2jn3A-3icaA:
undetectable		 2jn3A-3icaA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_1
(GAG-POL POLYPROTEIN)		 3ica PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Porphyromonas
gingivalis) 		6 / 12 LEU A 179
ASP A 110
ASP A 109
GLY A 113
ILE A 114
VAL A 171
 None
GOL  A 213 (-3.6A)
None
None
None
None
 1.49A 3jw2A-3icaA:
undetectable		 3jw2A-3icaA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 3ica PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Porphyromonas
gingivalis) 		3 / 3 TRP A 206
TRP A  86
THR A   8
 None
GOL  A 215 (-4.0A)
GOL  A 215 (-4.6A)
 1.34A 4bboB-3icaA:
undetectable		 4bboB-3icaA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 3ica PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Porphyromonas
gingivalis) 		5 / 9 LEU A  14
GLY A 113
VAL A 140
VAL A 144
LEU A 145
 None
 0.89A 4qd3A-3icaA:
undetectable		 4qd3A-3icaA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 3ica PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Porphyromonas
gingivalis) 		5 / 12 GLU A  68
GLY A  66
TYR A  33
GLU A 203
GLY A 113
 GOL  A 211 (-3.0A)
None
None
None
None
 1.36A 6gngA-3icaA:
undetectable		 6gngA-3icaA:
17.28