SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3icc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE
(Bacillus
anthracis) 		4 / 8 ILE A  16
ILE A  20
ARG A 139
ALA A   7
 ILE  A  16 (-0.7A)
ILE  A  20 ( 0.7A)
ARG  A 139 ( 0.6A)
ALA  A   7 ( 0.0A)
 0.64A 2nniA-3iccA:
undetectable		 2nniA-3iccA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE
(Bacillus
anthracis) 		5 / 12 ILE A  20
ALA A  19
GLY A  15
ILE A 224
GLY A  11
 ILE  A  20 ( 0.7A)
ALA  A  19 ( 0.0A)
GLY  A  15 ( 0.0A)
ILE  A 224 ( 0.7A)
GLY  A  11 ( 0.0A)
 0.85A 2qe6A-3iccA:
5.6		 2qe6A-3iccA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE
(Bacillus
anthracis) 		5 / 12 ILE A  20
ALA A  19
GLY A  15
ILE A 224
GLY A  11
 ILE  A  20 ( 0.7A)
ALA  A  19 ( 0.0A)
GLY  A  15 ( 0.0A)
ILE  A 224 ( 0.7A)
GLY  A  11 ( 0.0A)
 0.91A 2qe6B-3iccA:
5.4		 2qe6B-3iccA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE
(Bacillus
anthracis) 		4 / 4 SER A 250
GLY A 249
GLY A 189
GLY A 219
 SER  A 250 ( 0.0A)
GLY  A 249 ( 0.0A)
GLY  A 189 (-0.0A)
GLY  A 219 ( 0.0A)
 0.82A 3bogB-3iccA:
undetectable
3bogD-3iccA:
undetectable		 3bogB-3iccA:
undetectable
3bogD-3iccA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE
(Bacillus
anthracis) 		3 / 4 SER A 145
GLY A 101
GLU A 105
 SER  A 145 (-0.0A)
GLY  A 101 ( 0.0A)
GLU  A 105 ( 0.6A)
 0.49A 3raeA-3iccA:
undetectable
3raeC-3iccA:
3.0		 3raeA-3iccA:
20.69
3raeC-3iccA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE
(Bacillus
anthracis) 		4 / 5 SER A 145
ILE A  16
TYR A 158
GLY A 189
 SER  A 145 (-0.0A)
ILE  A  16 (-0.7A)
TYR  A 158 (-1.3A)
GLY  A 189 (-0.0A)
 1.04A 3uboB-3iccA:
6.9		 3uboB-3iccA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		 3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE
(Bacillus
anthracis) 		5 / 12 TYR A  73
ILE A 140
ALA A  21
ALA A  32
VAL A  31
 TYR  A  73 ( 1.3A)
ILE  A 140 ( 0.7A)
ALA  A  21 ( 0.0A)
ALA  A  32 ( 0.0A)
VAL  A  31 ( 0.6A)
 1.05A 4hfpD-3iccA:
undetectable		 4hfpD-3iccA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE
(Bacillus
anthracis) 		3 / 4 SER A 145
GLY A 101
GLU A 105
 SER  A 145 (-0.0A)
GLY  A 101 ( 0.0A)
GLU  A 105 ( 0.6A)
 0.52A 4juoA-3iccA:
undetectable
4juoC-3iccA:
2.8		 4juoA-3iccA:
20.69
4juoC-3iccA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE
(Bacillus
anthracis) 		4 / 5 LEU A 200
ARG A 217
PRO A 188
SER A 145
 LEU  A 200 ( 0.6A)
ARG  A 217 ( 0.6A)
PRO  A 188 (-1.1A)
SER  A 145 (-0.0A)
 1.31A 4kmmB-3iccA:
3.4		 4kmmB-3iccA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE
(Bacillus
anthracis) 		4 / 5 LEU A  76
LEU A  92
LEU A  80
ASN A  94
 LEU  A  76 ( 0.6A)
LEU  A  92 ( 0.6A)
LEU  A  80 ( 0.5A)
ASN  A  94 ( 0.6A)
 0.95A 4n09B-3iccA:
7.8		 4n09B-3iccA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE
(Bacillus
anthracis) 		3 / 3 ILE A 127
ILE A 181
MET A 168
 ILE  A 127 ( 0.7A)
ILE  A 181 ( 0.7A)
PHE  A 124 ( 3.8A)
 0.67A 5i9yA-3iccA:
undetectable		 5i9yA-3iccA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE
(Bacillus
anthracis) 		5 / 12 GLY A  15
GLY A  97
GLY A  11
GLY A  17
ILE A  98
 GLY  A  15 ( 0.0A)
GLY  A  97 (-0.0A)
GLY  A  11 ( 0.0A)
GLY  A  17 ( 0.0A)
ILE  A  98 (-0.7A)
 0.95A 5kqrA-3iccA:
5.0		 5kqrA-3iccA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE
(Bacillus
anthracis) 		5 / 12 GLY A  15
GLY A  97
GLY A  11
GLY A  17
ILE A  98
 GLY  A  15 ( 0.0A)
GLY  A  97 (-0.0A)
GLY  A  11 ( 0.0A)
GLY  A  17 ( 0.0A)
ILE  A  98 (-0.7A)
 0.96A 5njvC-3iccA:
4.7		 5njvC-3iccA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE
(Bacillus
anthracis) 		5 / 12 GLY A  15
GLY A  97
GLY A  11
GLY A  17
ILE A  98
 GLY  A  15 ( 0.0A)
GLY  A  97 (-0.0A)
GLY  A  11 ( 0.0A)
GLY  A  17 ( 0.0A)
ILE  A  98 (-0.7A)
 0.93A 5vimA-3iccA:
5.2		 5vimA-3iccA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE
(Bacillus
anthracis) 		5 / 12 GLY A  15
GLY A  97
GLY A  11
GLY A  17
ILE A  98
 GLY  A  15 ( 0.0A)
GLY  A  97 (-0.0A)
GLY  A  11 ( 0.0A)
GLY  A  17 ( 0.0A)
ILE  A  98 (-0.7A)
 0.97A 5vimB-3iccA:
5.4		 5vimB-3iccA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE
(Bacillus
anthracis) 		5 / 12 GLY A  15
GLY A  97
GLY A  11
GLY A  17
ILE A  98
 GLY  A  15 ( 0.0A)
GLY  A  97 (-0.0A)
GLY  A  11 ( 0.0A)
GLY  A  17 ( 0.0A)
ILE  A  98 (-0.7A)
 0.92A 5wz2C-3iccA:
5.4		 5wz2C-3iccA:
21.84