SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3icf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 261
SER A 454
THR A 250
PHE A 275
 None
 1.25A 1icuC-3icfA:
undetectable
1icuD-3icfA:
undetectable		 1icuC-3icfA:
20.06
1icuD-3icfA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 261
SER A 454
THR A 250
PHE A 275
 None
 1.33A 1icvA-3icfA:
undetectable
1icvB-3icfA:
undetectable		 1icvA-3icfA:
20.06
1icvB-3icfA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 278
HIS A 311
HIS A 251
 FE  A 601 (-2.5A)
PO4  A   1 (-3.8A)
FE  A 602 ( 3.2A)
 0.63A 1oe1A-3icfA:
undetectable		 1oe1A-3icfA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 278
HIS A 311
HIS A 251
 FE  A 601 (-2.5A)
PO4  A   1 (-3.8A)
FE  A 602 ( 3.2A)
 0.62A 1oe3A-3icfA:
undetectable		 1oe3A-3icfA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T
(Saccharomyces
cerevisiae) 		4 / 8 SER A 344
ARG A 378
PHE A 225
ASP A 222
 None
None
None
EDO  A 514 ( 3.9A)
 1.35A 1zzuA-3icfA:
undetectable		 1zzuA-3icfA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T
(Saccharomyces
cerevisiae) 		6 / 9 LEU A 356
GLY A 361
ASP A 395
GLY A 414
ILE A 417
ILE A 430
 None
 1.45A 2idwB-3icfA:
undetectable		 2idwB-3icfA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 430
ARG A 420
PHE A 421
PHE A 373
 None
 0.98A 2qb4A-3icfA:
undetectable		 2qb4A-3icfA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T
(Saccharomyces
cerevisiae) 		4 / 6 PRO A 363
ILE A 430
ASN A 425
LEU A 427
 None
 1.29A 2wekB-3icfA:
undetectable		 2wekB-3icfA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 278
HIS A 311
HIS A 251
 FE  A 601 (-2.5A)
PO4  A   1 (-3.8A)
FE  A 602 ( 3.2A)
 0.65A 2xxgA-3icfA:
undetectable		 2xxgA-3icfA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 278
HIS A 311
HIS A 251
 FE  A 601 (-2.5A)
PO4  A   1 (-3.8A)
FE  A 602 ( 3.2A)
 0.66A 2xxgC-3icfA:
undetectable		 2xxgC-3icfA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 317
LYS A 318
PRO A 382
PHE A 388
 None
 1.26A 3bjwD-3icfA:
undetectable		 3bjwD-3icfA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 469
GLY A 440
PHE A 453
LEU A 449
ARG A 432
 None
 1.10A 3em0B-3icfA:
undetectable		 3em0B-3icfA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 490
ILE A 469
VAL A 246
GLY A 248
ARG A 437
 None
 1.18A 3em0B-3icfA:
undetectable		 3em0B-3icfA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 226
ASP A 314
GLN A 332
 None
 0.69A 3lcvB-3icfA:
undetectable		 3lcvB-3icfA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 381
PHE A 388
PRO A 383
LEU A 392
 None
 1.40A 3tgvD-3icfA:
undetectable		 3tgvD-3icfA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 248
ASP A 249
ASP A 281
VAL A 280
ASN A 307
 None
FE  A 602 (-3.1A)
None
None
None
 1.27A 3v8vB-3icfA:
undetectable		 3v8vB-3icfA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 308
LEU A 347
ALA A 387
ILE A 376
 None
 0.97A 3wsjB-3icfA:
undetectable		 3wsjB-3icfA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 259
LEU A 204
PHE A 261
 None
 0.78A 4dajB-3icfA:
undetectable		 4dajB-3icfA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 429
TYR A 355
ARG A 428
 None
 1.39A 4gc9A-3icfA:
undetectable		 4gc9A-3icfA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 430
ALA A 348
LEU A 427
LEU A 350
PHE A 373
 None
 1.34A 4pbhA-3icfA:
undetectable		 4pbhA-3icfA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 356
ILE A 430
PRO A 363
LEU A 391
 None
 1.19A 5eb3A-3icfA:
undetectable		 5eb3A-3icfA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T
(Saccharomyces
cerevisiae) 		5 / 8 HIS A 251
GLY A 309
GLY A 277
VAL A 280
HIS A 311
 FE  A 602 ( 3.2A)
None
None
None
PO4  A   1 (-3.8A)
 1.48A 5f8yB-3icfA:
undetectable		 5f8yB-3icfA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 432
ASP A 278
GLY A 277
ASP A 249
 None
FE  A 601 (-2.5A)
None
FE  A 602 (-3.1A)
 1.44A 5hp1C-3icfA:
undetectable		 5hp1C-3icfA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T
(Saccharomyces
cerevisiae) 		4 / 4 ASP A 278
HIS A 359
HIS A 434
HIS A 311
 FE  A 601 (-2.5A)
FE  A 601 (-3.1A)
FE  A 601 ( 2.9A)
PO4  A   1 (-3.8A)
 1.49A 5ncdD-3icfA:
undetectable		 5ncdD-3icfA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_2
(RIBOFLAVIN LYASE)		 3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T
(Saccharomyces
cerevisiae) 		4 / 5 GLN A 397
ASP A 395
SER A 405
ARG A 407
 None
None
None
PO4  A   1 (-3.1A)
 1.35A 5w4zA-3icfA:
undetectable		 5w4zA-3icfA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T
(Saccharomyces
cerevisiae) 		5 / 11 MET A 231
PHE A 373
ILE A 376
LEU A 370
ILE A 430
 None
 1.12A 6fgcA-3icfA:
undetectable		 6fgcA-3icfA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_D8ZA831_0
(GEPHYRIN)		 3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T
(Saccharomyces
cerevisiae) 		5 / 11 MET A 231
PHE A 373
ILE A 376
LEU A 370
ILE A 430
 None
 1.23A 6fgdA-3icfA:
undetectable		 6fgdA-3icfA:
14.24