SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3icj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		5 / 12 HIS A  99
HIS A 101
ASP A 103
HIS A 371
ASP A 432
 ZN  A 601 (-3.5A)
ZN  A 601 (-3.5A)
None
ZN  A 602 (-3.5A)
ZN  A 601 (-2.6A)
 0.97A 1a4lA-3icjA:
17.9		 1a4lA-3icjA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		5 / 12 HIS A  99
HIS A 101
ASP A 103
HIS A 371
ASP A 432
 ZN  A 601 (-3.5A)
ZN  A 601 (-3.5A)
None
ZN  A 602 (-3.5A)
ZN  A 601 (-2.6A)
 0.93A 1a4lC-3icjA:
17.9		 1a4lC-3icjA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		3 / 3 VAL A 398
TRP A 401
TRP A 402
 None
 1.45A 1c4dA-3icjA:
undetectable
1c4dB-3icjA:
undetectable		 1c4dA-3icjA:
4.72
1c4dB-3icjA:
4.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		5 / 10 ARG A 489
LEU A 288
ALA A 265
PHE A 264
GLY A 292
 None
 1.27A 1cmcA-3icjA:
undetectable
1cmcB-3icjA:
undetectable		 1cmcA-3icjA:
11.60
1cmcB-3icjA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		5 / 11 LEU A 380
VAL A 375
ILE A 369
ILE A 390
GLN A 379
 None
 1.11A 1gx9A-3icjA:
undetectable		 1gx9A-3icjA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		5 / 12 ALA A 265
PHE A 264
GLY A 292
ARG A 489
GLU A 254
 None
 1.31A 1mj2A-3icjA:
undetectable
1mj2B-3icjA:
undetectable		 1mj2A-3icjA:
12.74
1mj2B-3icjA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		4 / 7 ILE A 390
GLU A 457
LEU A 467
GLY A 428
 None
 0.87A 1mt1H-3icjA:
undetectable
1mt1K-3icjA:
undetectable		 1mt1H-3icjA:
11.86
1mt1K-3icjA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		4 / 8 LEU A 467
GLY A 428
ILE A 390
GLU A 457
 None
 0.90A 1n13A-3icjA:
undetectable
1n13F-3icjA:
undetectable		 1n13A-3icjA:
10.18
1n13F-3icjA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		5 / 12 TYR A 221
ILE A 135
VAL A 112
ALA A 225
SER A 224
 None
 1.21A 1nbhA-3icjA:
undetectable		 1nbhA-3icjA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		5 / 12 TYR A 221
ILE A 135
VAL A 112
ALA A 225
SER A 224
 None
 1.21A 1nbhC-3icjA:
undetectable		 1nbhC-3icjA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		5 / 12 TYR A 221
ILE A 135
VAL A 112
ALA A 225
SER A 224
 None
 1.22A 1nbhD-3icjA:
undetectable		 1nbhD-3icjA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		5 / 12 HIS A  99
HIS A 101
ASP A 103
HIS A 371
ASP A 432
 ZN  A 601 (-3.5A)
ZN  A 601 (-3.5A)
None
ZN  A 602 (-3.5A)
ZN  A 601 (-2.6A)
 0.66A 2pgrA-3icjA:
8.0		 2pgrA-3icjA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		3 / 3 ARG A 389
GLU A 284
SER A 391
 None
 0.63A 2xkkA-3icjA:
undetectable
2xkkC-3icjA:
0.8		 2xkkA-3icjA:
22.90
2xkkC-3icjA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		4 / 8 SER A  98
THR A 476
VAL A 475
ALA A 344
 None
None
None
KCX  A 294 ( 4.1A)
 0.86A 3ax7A-3icjA:
undetectable		 3ax7A-3icjA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		4 / 8 SER A  98
THR A 476
VAL A 475
ALA A 344
 None
None
None
KCX  A 294 ( 4.1A)
 0.91A 3ax9A-3icjA:
undetectable		 3ax9A-3icjA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 163
GLY A 137
SER A 108
ILE A 135
LEU A 114
 None
 0.86A 3cjtO-3icjA:
2.1		 3cjtO-3icjA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		5 / 10 LEU A 421
ILE A 383
ARG A 382
SER A  98
GLY A 367
 None
 1.34A 3hcpB-3icjA:
undetectable		 3hcpB-3icjA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		5 / 12 ASP A 432
GLY A 367
GLY A 292
ASP A  97
PHE A 365
 ZN  A 601 (-2.6A)
None
None
None
None
 0.83A 3prsA-3icjA:
undetectable		 3prsA-3icjA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		4 / 6 ALA A 265
ILE A 290
LEU A 267
ALA A 246
 None
 0.78A 3r9sA-3icjA:
3.0		 3r9sA-3icjA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		4 / 6 ALA A 265
ILE A 290
LEU A 267
ALA A 246
 None
 0.76A 3r9sC-3icjA:
2.9		 3r9sC-3icjA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		4 / 8 ALA A 265
ILE A 290
LEU A 267
ALA A 246
 None
 0.68A 3r9tA-3icjA:
3.0		 3r9tA-3icjA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		4 / 5 LEU A 272
LEU A 341
GLY A 340
GLY A 281
 None
 0.83A 3si7C-3icjA:
undetectable
3si7D-3icjA:
undetectable		 3si7C-3icjA:
20.78
3si7D-3icjA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		4 / 7 TYR A 416
ASP A 400
SER A 399
HIS A 395
 None
 1.36A 4arcA-3icjA:
undetectable		 4arcA-3icjA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		5 / 6 HIS A  99
HIS A 101
HIS A 346
HIS A 371
ASP A 432
 ZN  A 601 (-3.5A)
ZN  A 601 (-3.5A)
ZN  A 602 (-3.2A)
ZN  A 602 (-3.5A)
ZN  A 601 (-2.6A)
 0.79A 4ubpC-3icjA:
16.5		 4ubpC-3icjA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		3 / 3 LEU A 386
VAL A 353
ASP A 354
 None
 0.42A 4y8wC-3icjA:
undetectable		 4y8wC-3icjA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		3 / 3 ARG A 133
THR A 214
ASP A 217
 None
 0.84A 5g5gA-3icjA:
undetectable
5g5gB-3icjA:
undetectable		 5g5gA-3icjA:
17.14
5g5gB-3icjA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		3 / 3 HIS A 466
SER A  46
LYS A 483
 None
 1.21A 5os7A-3icjA:
undetectable		 5os7A-3icjA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		4 / 4 LEU A  86
GLY A  41
SER A  54
SER A  69
 None
 1.21A 5uunA-3icjA:
undetectable		 5uunA-3icjA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		4 / 4 LEU A  86
GLY A  41
SER A  54
SER A  69
 None
 1.31A 5uunB-3icjA:
undetectable		 5uunB-3icjA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		3 / 3 HIS A 466
SER A  46
LYS A 483
 None
 1.21A 6gmdB-3icjA:
undetectable		 6gmdB-3icjA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		5 / 12 HIS A 101
ASP A 103
SER A 268
HIS A 371
ASP A 432
 ZN  A 601 (-3.5A)
None
None
ZN  A 602 (-3.5A)
ZN  A 601 (-2.6A)
 1.03A 6n91A-3icjA:
16.6		 6n91A-3icjA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
furiosus) 		5 / 12 HIS A 101
ASP A 103
SER A 268
HIS A 371
ASP A 432
 ZN  A 601 (-3.5A)
None
None
ZN  A 602 (-3.5A)
ZN  A 601 (-2.6A)
 1.03A 6n91B-3icjA:
18.2		 6n91B-3icjA:
10.69