SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3icl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 3icl EAL/GGDEF DOMAIN
PROTEIN
(Methylococcus
capsulatus) 		5 / 12 PHE A  34
GLY A 123
ALA A 125
VAL A 120
SER A 121
 None
 1.16A 1sg9C-3iclA:
undetectable		 1sg9C-3iclA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B8J_A_SPMA653_1
(CLASS B ACID
PHOSPHATASE)		 3icl EAL/GGDEF DOMAIN
PROTEIN
(Methylococcus
capsulatus) 		5 / 9 PHE A  34
GLY A  77
ASP A  79
THR A 143
TYR A 146
 None
None
SO4  A 171 ( 4.0A)
None
SO4  A 171 (-4.7A)
 1.33A 2b8jA-3iclA:
0.0		 2b8jA-3iclA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3icl EAL/GGDEF DOMAIN
PROTEIN
(Methylococcus
capsulatus) 		3 / 3 VAL A  30
SER A 127
LEU A  20
 None
 0.75A 3n8xA-3iclA:
undetectable		 3n8xA-3iclA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 3icl EAL/GGDEF DOMAIN
PROTEIN
(Methylococcus
capsulatus) 		5 / 12 ALA A  66
LEU A 102
ILE A 124
GLY A  94
LEU A  85
 None
 0.99A 4xi3B-3iclA:
undetectable		 4xi3B-3iclA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 3icl EAL/GGDEF DOMAIN
PROTEIN
(Methylococcus
capsulatus) 		5 / 12 ILE A 116
LEU A 105
VAL A  37
LEU A  47
THR A  59
 None
 1.06A 5bykA-3iclA:
undetectable		 5bykA-3iclA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 3icl EAL/GGDEF DOMAIN
PROTEIN
(Methylococcus
capsulatus) 		5 / 12 ILE A 116
LEU A 105
VAL A  37
LEU A  47
THR A  59
 None
 1.08A 6b54A-3iclA:
undetectable		 6b54A-3iclA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 3icl EAL/GGDEF DOMAIN
PROTEIN
(Methylococcus
capsulatus) 		5 / 12 LEU A  35
ILE A 122
GLY A 123
ILE A  63
VAL A  67
 None
 0.93A 6emuA-3iclA:
undetectable		 6emuA-3iclA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 3icl EAL/GGDEF DOMAIN
PROTEIN
(Methylococcus
capsulatus) 		5 / 12 LEU A  35
ILE A 122
GLY A 123
ILE A  63
VAL A  67
 None
 0.93A 6emuC-3iclA:
undetectable		 6emuC-3iclA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 3icl EAL/GGDEF DOMAIN
PROTEIN
(Methylococcus
capsulatus) 		4 / 6 GLU A  24
HIS A  23
ALA A  19
GLN A  18
 None
 1.37A 6f6jC-3iclA:
undetectable
6f6jD-3iclA:
undetectable		 6f6jC-3iclA:
19.06
6f6jD-3iclA:
19.06