SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3icu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3icu E3 UBIQUITIN-PROTEIN
LIGASE RNF128
(Homo
sapiens) 		5 / 12 LEU A  84
LEU A 117
ALA A 143
LEU A  47
ILE A 179
 None
 1.09A 1s9pD-3icuA:
undetectable		 1s9pD-3icuA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3icu E3 UBIQUITIN-PROTEIN
LIGASE RNF128
(Homo
sapiens) 		4 / 8 LEU A 119
ILE A 179
GLU A  68
ILE A 145
 None
 0.92A 2azxA-3icuA:
undetectable		 2azxA-3icuA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 3icu E3 UBIQUITIN-PROTEIN
LIGASE RNF128
(Homo
sapiens) 		4 / 8 SER A  75
LEU A  47
LEU A  84
LEU A 119
 None
 0.93A 2bfpB-3icuA:
undetectable		 2bfpB-3icuA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 3icu E3 UBIQUITIN-PROTEIN
LIGASE RNF128
(Homo
sapiens) 		5 / 9 GLY A 172
ILE A 179
VAL A 144
ILE A 193
VAL A  80
 None
 1.25A 2nnhB-3icuA:
undetectable		 2nnhB-3icuA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 3icu E3 UBIQUITIN-PROTEIN
LIGASE RNF128
(Homo
sapiens) 		4 / 8 GLY A  69
MET A 158
LEU A  47
ILE A 193
 None
 0.80A 3nbqB-3icuA:
undetectable		 3nbqB-3icuA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 3icu E3 UBIQUITIN-PROTEIN
LIGASE RNF128
(Homo
sapiens) 		4 / 8 GLY A  69
MET A 158
LEU A  47
ILE A 193
 None
 0.80A 3nbqC-3icuA:
undetectable		 3nbqC-3icuA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 3icu E3 UBIQUITIN-PROTEIN
LIGASE RNF128
(Homo
sapiens) 		4 / 7 PRO A  76
LEU A 117
TYR A  71
ILE A 169
 None
 0.71A 3p50A-3icuA:
undetectable		 3p50A-3icuA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 3icu E3 UBIQUITIN-PROTEIN
LIGASE RNF128
(Homo
sapiens) 		4 / 7 PRO A  76
LEU A 117
TYR A  71
ILE A 169
 None
 0.72A 3p50B-3icuA:
undetectable		 3p50B-3icuA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 3icu E3 UBIQUITIN-PROTEIN
LIGASE RNF128
(Homo
sapiens) 		4 / 7 PRO A  76
LEU A 117
TYR A  71
ILE A 169
 None
 0.72A 3p50C-3icuA:
undetectable		 3p50C-3icuA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 3icu E3 UBIQUITIN-PROTEIN
LIGASE RNF128
(Homo
sapiens) 		4 / 7 PRO A  76
LEU A 117
TYR A  71
ILE A 169
 None
 0.71A 3p50D-3icuA:
undetectable		 3p50D-3icuA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 3icu E3 UBIQUITIN-PROTEIN
LIGASE RNF128
(Homo
sapiens) 		4 / 7 PRO A  76
LEU A 117
TYR A  71
ILE A 169
 None
 0.72A 3p50E-3icuA:
undetectable		 3p50E-3icuA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 3icu E3 UBIQUITIN-PROTEIN
LIGASE RNF128
(Homo
sapiens) 		3 / 3 ARG A 122
PHE A 148
PRO A 149
 None
 0.71A 3zoaB-3icuA:
undetectable		 3zoaB-3icuA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3icu E3 UBIQUITIN-PROTEIN
LIGASE RNF128
(Homo
sapiens) 		5 / 10 THR A 127
ALA A 168
ALA A 143
GLY A 162
ASP A 165
 None
 1.04A 4qvyK-3icuA:
undetectable
4qvyL-3icuA:
undetectable		 4qvyK-3icuA:
23.11
4qvyL-3icuA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3icu E3 UBIQUITIN-PROTEIN
LIGASE RNF128
(Homo
sapiens) 		4 / 7 VAL A  49
ILE A 171
ALA A  45
ILE A 145
 None
 0.86A 4uxqA-3icuA:
undetectable		 4uxqA-3icuA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H1E_A_VDXA501_1
(VITAMIN D3 RECEPTOR)		 3icu E3 UBIQUITIN-PROTEIN
LIGASE RNF128
(Homo
sapiens) 		5 / 12 PHE A 146
LEU A 119
ILE A 183
SER A 182
VAL A  49
 None
 1.49A 5h1eA-3icuA:
undetectable		 5h1eA-3icuA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3icu E3 UBIQUITIN-PROTEIN
LIGASE RNF128
(Homo
sapiens) 		4 / 6 PHE A 148
PRO A 149
GLY A 150
THR A 151
 None
 0.85A 5x24A-3icuA:
undetectable		 5x24A-3icuA:
17.11