SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3icv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 3icv LIPASE B
(Moesziomyces
antarcticus) 		4 / 8 ASP A 221
GLY A 141
GLY A 171
GLN A 191
 None
 0.84A 1jr1B-3icvA:
undetectable		 1jr1B-3icvA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3icv LIPASE B
(Moesziomyces
antarcticus) 		4 / 5 SER A 261
TYR A 169
SER A 229
ASP A 221
 None
None
NAG  A 401 (-2.5A)
None
 1.47A 1vidA-3icvA:
undetectable		 1vidA-3icvA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 3icv LIPASE B
(Moesziomyces
antarcticus) 		4 / 4 GLY A  73
SER A 139
ILE A 223
HIS A 258
 None
None
BTB  A 403 ( 4.7A)
BTB  A 403 ( 4.9A)
 1.12A 1yajJ-3icvA:
11.6		 1yajJ-3icvA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 3icv LIPASE B
(Moesziomyces
antarcticus) 		5 / 10 ALA A 166
LEU A  70
LEU A 136
SER A 261
ASN A  85
 None
 1.27A 2ceoB-3icvA:
undetectable		 2ceoB-3icvA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3icv LIPASE B
(Moesziomyces
antarcticus) 		5 / 12 ALA A 164
VAL A 224
ASP A 221
TYR A 169
SER A 236
 None
 0.96A 2dcfA-3icvA:
undetectable		 2dcfA-3icvA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 3icv LIPASE B
(Moesziomyces
antarcticus) 		5 / 12 GLY A 142
PRO A  72
GLY A  73
ALA A 145
LEU A 149
 None
 1.05A 2plwA-3icvA:
undetectable		 2plwA-3icvA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 3icv LIPASE B
(Moesziomyces
antarcticus) 		4 / 6 ILE A 155
PRO A 102
LEU A  54
ILE A 100
 None
 1.04A 2q83B-3icvA:
undetectable		 2q83B-3icvA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3icv LIPASE B
(Moesziomyces
antarcticus) 		4 / 7 ILE A  87
GLN A  92
LEU A  93
LEU A 136
 None
 1.03A 2qqcB-3icvA:
undetectable
2qqcC-3icvA:
undetectable		 2qqcB-3icvA:
17.25
2qqcC-3icvA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3icv LIPASE B
(Moesziomyces
antarcticus) 		4 / 7 LEU A  93
LEU A 136
ILE A  87
GLN A  92
 None
 1.01A 2qqcA-3icvA:
undetectable
2qqcF-3icvA:
undetectable		 2qqcA-3icvA:
14.56
2qqcF-3icvA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3icv LIPASE B
(Moesziomyces
antarcticus) 		4 / 7 LEU A  93
LEU A 136
ILE A  87
GLN A  92
 None
 1.05A 2qqcI-3icvA:
undetectable
2qqcL-3icvA:
undetectable		 2qqcI-3icvA:
14.56
2qqcL-3icvA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3icv LIPASE B
(Moesziomyces
antarcticus) 		4 / 7 LEU A 216
VAL A 270
GLY A 271
THR A 213
 None
 0.80A 2wd9A-3icvA:
3.7		 2wd9A-3icvA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3icv LIPASE B
(Moesziomyces
antarcticus) 		5 / 12 ALA A 164
VAL A 224
ASP A 221
TYR A 169
SER A 236
 None
 1.08A 3a65A-3icvA:
undetectable		 3a65A-3icvA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 3icv LIPASE B
(Moesziomyces
antarcticus) 		5 / 12 THR A  77
GLN A 140
GLY A 141
GLY A  53
ASN A 119
 None
 1.26A 3v3oA-3icvA:
undetectable		 3v3oA-3icvA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 3icv LIPASE B
(Moesziomyces
antarcticus) 		4 / 5 VAL A 144
GLY A 141
TYR A 169
ASP A 168
 None
 1.45A 3w9tA-3icvA:
undetectable		 3w9tA-3icvA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 3icv LIPASE B
(Moesziomyces
antarcticus) 		4 / 5 VAL A 144
GLY A 141
TYR A 169
ASP A 168
 None
 1.44A 3w9tB-3icvA:
undetectable		 3w9tB-3icvA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 3icv LIPASE B
(Moesziomyces
antarcticus) 		4 / 5 VAL A 144
GLY A 141
TYR A 169
ASP A 168
 None
 1.45A 3w9tC-3icvA:
undetectable		 3w9tC-3icvA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 3icv LIPASE B
(Moesziomyces
antarcticus) 		4 / 5 VAL A 144
GLY A 141
TYR A 169
ASP A 168
 None
 1.45A 3w9tD-3icvA:
undetectable		 3w9tD-3icvA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 3icv LIPASE B
(Moesziomyces
antarcticus) 		4 / 5 VAL A 144
GLY A 141
TYR A 169
ASP A 168
 None
 1.45A 3w9tE-3icvA:
undetectable		 3w9tE-3icvA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 3icv LIPASE B
(Moesziomyces
antarcticus) 		4 / 5 VAL A 144
GLY A 141
TYR A 169
ASP A 168
 None
 1.45A 3w9tF-3icvA:
undetectable		 3w9tF-3icvA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 3icv LIPASE B
(Moesziomyces
antarcticus) 		4 / 5 VAL A 144
GLY A 141
TYR A 169
ASP A 168
 None
 1.44A 3w9tG-3icvA:
undetectable		 3w9tG-3icvA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BCS_A_ACTA1126_0
(CHIMERIC AVIDIN)		 3icv LIPASE B
(Moesziomyces
antarcticus) 		4 / 4 THR A 214
GLN A 281
ARG A 161
THR A 279
 None
 1.49A 4bcsA-3icvA:
0.0		 4bcsA-3icvA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3icv LIPASE B
(Moesziomyces
antarcticus) 		3 / 3 GLN A 191
THR A 192
THR A 172
 None
 0.82A 4fufA-3icvA:
undetectable		 4fufA-3icvA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 3icv LIPASE B
(Moesziomyces
antarcticus) 		4 / 7 THR A  96
TYR A  95
PRO A  67
SER A  90
 None
 1.01A 5b6iA-3icvA:
2.7		 5b6iA-3icvA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3icv LIPASE B
(Moesziomyces
antarcticus) 		4 / 5 SER A 261
TYR A 169
SER A 229
ASP A 221
 None
None
NAG  A 401 (-2.5A)
None
 1.48A 5fhrA-3icvA:
undetectable		 5fhrA-3icvA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 3icv LIPASE B
(Moesziomyces
antarcticus) 		4 / 7 GLN A 191
LEU A 143
ALA A 164
LEU A 136
 None
 0.99A 5nwvA-3icvA:
undetectable		 5nwvA-3icvA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3icv LIPASE B
(Moesziomyces
antarcticus) 		4 / 8 TRP A  86
THR A 137
THR A 214
ARG A 161
 None
 1.42A 5tzoB-3icvA:
undetectable		 5tzoB-3icvA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 3icv LIPASE B
(Moesziomyces
antarcticus) 		4 / 6 PHE A 152
GLY A 148
THR A 114
GLN A 111
 None
 1.17A 6ag0A-3icvA:
undetectable		 6ag0A-3icvA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 3icv LIPASE B
(Moesziomyces
antarcticus) 		4 / 6 PHE A 152
GLY A 148
THR A 114
GLN A 111
 None
 1.14A 6ag0C-3icvA:
undetectable		 6ag0C-3icvA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 3icv LIPASE B
(Moesziomyces
antarcticus) 		5 / 12 LEU A 124
VAL A  71
VAL A 135
PRO A 102
LEU A  54
 None
 1.45A 6eliA-3icvA:
undetectable		 6eliA-3icvA:
12.62