SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3icy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3icy SENSOR PROTEIN
(Chlorobaculum
tepidum) 		4 / 7 GLY A 109
ALA A   0
THR A  75
SER A  -2
 None
 0.89A 1c9sT-3icyA:
undetectable
1c9sU-3icyA:
undetectable		 1c9sT-3icyA:
23.66
1c9sU-3icyA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3icy SENSOR PROTEIN
(Chlorobaculum
tepidum) 		4 / 7 GLY A 109
ALA A   0
THR A  75
SER A  -2
 None
 0.90A 1gtfL-3icyA:
undetectable
1gtfM-3icyA:
undetectable		 1gtfL-3icyA:
23.66
1gtfM-3icyA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3icy SENSOR PROTEIN
(Chlorobaculum
tepidum) 		4 / 7 GLY A 109
ALA A   0
THR A  75
SER A  -2
 None
 0.83A 1gtnA-3icyA:
undetectable
1gtnK-3icyA:
undetectable		 1gtnA-3icyA:
23.66
1gtnK-3icyA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 3icy SENSOR PROTEIN
(Chlorobaculum
tepidum) 		4 / 8 GLU A   2
SER A  73
GLU A   1
GLU A  91
 None
 1.12A 1knyA-3icyA:
undetectable
1knyB-3icyA:
undetectable		 1knyA-3icyA:
20.56
1knyB-3icyA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3icy SENSOR PROTEIN
(Chlorobaculum
tepidum) 		4 / 6 ILE A 107
GLU A   1
ASP A  92
LEU A  76
 None
None
None
GOL  A 116 ( 4.6A)
 1.02A 1mt1B-3icyA:
undetectable
1mt1C-3icyA:
undetectable		 1mt1B-3icyA:
23.26
1mt1C-3icyA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3icy SENSOR PROTEIN
(Chlorobaculum
tepidum) 		4 / 8 LEU A 111
ILE A  90
PHE A  32
LEU A  36
 None
 0.85A 2azxA-3icyA:
undetectable		 2azxA-3icyA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3icy SENSOR PROTEIN
(Chlorobaculum
tepidum) 		4 / 8 GLY A 102
ILE A 107
SER A  99
TYR A  64
 None
 0.93A 2yoeB-3icyA:
undetectable
2yoeC-3icyA:
undetectable		 2yoeB-3icyA:
15.36
2yoeC-3icyA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 3icy SENSOR PROTEIN
(Chlorobaculum
tepidum) 		3 / 3 PRO A  83
PHE A  32
LYS A  86
 None
 1.14A 3bjwG-3icyA:
undetectable		 3bjwG-3icyA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3icy SENSOR PROTEIN
(Chlorobaculum
tepidum) 		4 / 8 SER A  -2
GLY A 109
ALA A   0
THR A  75
 None
 0.93A 5eevL-3icyA:
undetectable
5eevV-3icyA:
undetectable		 5eevL-3icyA:
23.66
5eevV-3icyA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3icy SENSOR PROTEIN
(Chlorobaculum
tepidum) 		4 / 8 SER A  -2
GLY A 109
ALA A   0
THR A  75
 None
 0.93A 5eewL-3icyA:
undetectable
5eewV-3icyA:
undetectable		 5eewL-3icyA:
23.66
5eewV-3icyA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3icy SENSOR PROTEIN
(Chlorobaculum
tepidum) 		4 / 8 SER A  -2
GLY A 109
ALA A   0
THR A  75
 None
 0.92A 5ef3L-3icyA:
undetectable
5ef3V-3icyA:
undetectable		 5ef3L-3icyA:
23.66
5ef3V-3icyA:
23.66