SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ie5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 3ie5 PHENOLIC OXIDATIVE
COUPLING PROTEIN
HYP-1
(Hypericum
perforatum) 		3 / 3 LEU A  69
VAL A  91
ASP A  90
 None
PG4  A 502 ( 4.7A)
None
 0.52A 4y8wC-3ie5A:
undetectable		 4y8wC-3ie5A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3ie5 PHENOLIC OXIDATIVE
COUPLING PROTEIN
HYP-1
(Hypericum
perforatum) 		4 / 7 ILE A  44
LYS A  71
GLY A  50
GLY A  49
 None
PG4  A 508 (-2.8A)
None
None
 0.79A 5a06A-3ie5A:
undetectable		 5a06A-3ie5A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3ie5 PHENOLIC OXIDATIVE
COUPLING PROTEIN
HYP-1
(Hypericum
perforatum) 		4 / 7 ILE A  44
LYS A  71
GLY A  50
GLY A  49
 None
PG4  A 508 (-2.8A)
None
None
 0.81A 5a06C-3ie5A:
undetectable		 5a06C-3ie5A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3ie5 PHENOLIC OXIDATIVE
COUPLING PROTEIN
HYP-1
(Hypericum
perforatum) 		4 / 6 LYS A  71
GLY A  50
GLY A  49
ASP A  48
 PG4  A 508 (-2.8A)
None
None
None
 0.69A 5a06D-3ie5A:
undetectable		 5a06D-3ie5A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3ie5 PHENOLIC OXIDATIVE
COUPLING PROTEIN
HYP-1
(Hypericum
perforatum) 		4 / 7 ILE A  44
LYS A  71
GLY A  50
GLY A  49
 None
PG4  A 508 (-2.8A)
None
None
 0.80A 5a06E-3ie5A:
undetectable		 5a06E-3ie5A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3ie5 PHENOLIC OXIDATIVE
COUPLING PROTEIN
HYP-1
(Hypericum
perforatum) 		4 / 7 ILE A  44
LYS A  71
GLY A  50
GLY A  49
 None
PG4  A 508 (-2.8A)
None
None
 0.78A 5a06F-3ie5A:
undetectable		 5a06F-3ie5A:
17.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 3ie5 PHENOLIC OXIDATIVE
COUPLING PROTEIN
HYP-1
(Hypericum
perforatum) 		7 / 12 ARG A  27
VAL A  38
HIS A  63
LEU A  65
VAL A  91
TYR A 101
TYR A 120
 PG4  A 502 (-4.6A)
None
None
None
PG4  A 502 ( 4.7A)
None
PG4  A 502 (-4.8A)
 1.31A 5i8fA-3ie5A:
26.8		 5i8fA-3ie5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 3ie5 PHENOLIC OXIDATIVE
COUPLING PROTEIN
HYP-1
(Hypericum
perforatum) 		9 / 12 GLN A  35
VAL A  38
PHE A  39
HIS A  63
LEU A  65
VAL A  91
TYR A 101
TYR A 120
GLY A 136
 None
None
PG4  A 502 (-4.8A)
None
None
PG4  A 502 ( 4.7A)
None
PG4  A 502 (-4.8A)
PG4  A 502 ( 4.1A)
 0.88A 5i8fA-3ie5A:
26.8		 5i8fA-3ie5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 3ie5 PHENOLIC OXIDATIVE
COUPLING PROTEIN
HYP-1
(Hypericum
perforatum) 		5 / 12 GLN A  35
VAL A  38
PHE A  39
HIS A  63
TYR A  84
 None
None
PG4  A 502 (-4.8A)
None
None
 0.89A 5i8fA-3ie5A:
26.8		 5i8fA-3ie5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 3ie5 PHENOLIC OXIDATIVE
COUPLING PROTEIN
HYP-1
(Hypericum
perforatum) 		5 / 12 LEU A  31
VAL A  38
PHE A  39
HIS A  63
LEU A  65
 None
None
PG4  A 502 (-4.8A)
None
None
 1.03A 5i8fA-3ie5A:
26.8		 5i8fA-3ie5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 3ie5 PHENOLIC OXIDATIVE
COUPLING PROTEIN
HYP-1
(Hypericum
perforatum) 		5 / 12 LEU A  31
VAL A  38
PHE A  39
HIS A  63
TYR A  84
 None
None
PG4  A 502 (-4.8A)
None
None
 1.23A 5i8fA-3ie5A:
26.8		 5i8fA-3ie5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 3ie5 PHENOLIC OXIDATIVE
COUPLING PROTEIN
HYP-1
(Hypericum
perforatum) 		8 / 12 VAL A  38
HIS A  63
LEU A  65
VAL A  91
TYR A 101
TYR A 120
GLY A 136
LYS A 139
 None
None
None
PG4  A 502 ( 4.7A)
None
PG4  A 502 (-4.8A)
PG4  A 502 ( 4.1A)
None
 1.16A 5i8fA-3ie5A:
26.8		 5i8fA-3ie5A:
100.00