SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iec'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 12 VAL A  67
ALA A  80
MET A 104
GLY A 135
LEU A 182
ALA A 192
 None
 0.60A 1iepA-3iecA:
22.4		 1iepA-3iecA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 9 GLY A  60
VAL A  67
ALA A  80
TYR A 131
ALA A 132
LEU A 182
 None
 0.51A 1muoA-3iecA:
10.5		 1muoA-3iecA:
29.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 12 VAL A  67
ALA A  80
MET A 104
VAL A 113
ALA A 192
ASP A 193
 None
 0.63A 1opjA-3iecA:
22.4		 1opjA-3iecA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 12 VAL A  67
ALA A  80
MET A 104
VAL A 113
LEU A 182
ALA A 192
 None
 0.73A 1opjA-3iecA:
22.4		 1opjA-3iecA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 VAL A  67
ALA A  80
MET A 104
VAL A 113
GLY A 135
ALA A 192
ASP A 193
 None
 0.84A 1opjB-3iecA:
22.4		 1opjB-3iecA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		4 / 7 ASN A 180
HIS A 173
PHE A 194
ILE A 159
 None
 1.29A 1tdnA-3iecA:
undetectable		 1tdnA-3iecA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		4 / 7 ASN A 180
HIS A 173
PHE A 194
ILE A 189
 None
 1.44A 1tdnA-3iecA:
undetectable		 1tdnA-3iecA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		4 / 6 ILE A  59
VAL A  67
ILE A 112
ASP A 193
 None
 0.68A 1uwhA-3iecA:
23.6		 1uwhA-3iecA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		4 / 6 ILE A  59
VAL A  67
ILE A 112
ILE A 171
 None
 0.79A 1uwhA-3iecA:
23.6		 1uwhA-3iecA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		5 / 6 ILE A  59
VAL A  67
ILE A 112
ILE A 171
ASP A 193
 None
 0.90A 1uwhB-3iecA:
23.5		 1uwhB-3iecA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		4 / 7 ILE A  59
LYS A  82
ILE A 112
ASP A 193
 None
 0.78A 1uwjA-3iecA:
6.6		 1uwjA-3iecA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		4 / 7 ILE A  59
LYS A  82
ILE A 112
ILE A 171
 None
 0.88A 1uwjA-3iecA:
6.6		 1uwjA-3iecA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 12 ALA A  80
MET A 104
GLY A 135
ASP A 139
LEU A 182
PHE A 194
 None
 1.14A 1xkkA-3iecA:
21.7		 1xkkA-3iecA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 12 MET A 104
GLY A 135
ASP A 139
LEU A 182
ASP A 193
PHE A 194
 None
 1.23A 1xkkA-3iecA:
21.7		 1xkkA-3iecA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		4 / 6 TYR A 215
GLY A 195
PHE A 196
SER A 197
 None
 1.25A 2a3cA-3iecA:
undetectable		 2a3cA-3iecA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		3 / 3 LYS A 283
ASP A 311
ASP A 301
 None
 0.86A 2br4D-3iecA:
undetectable		 2br4D-3iecA:
22.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 11 GLY A  60
VAL A  67
ALA A  80
TYR A 131
ALA A 132
LEU A 182
 None
 0.58A 2evaA-3iecA:
23.0		 2evaA-3iecA:
32.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 ALA A  80
LYS A  82
MET A 104
VAL A 113
GLY A 135
LEU A 182
ALA A 192
 None
 0.82A 2gqgA-3iecA:
25.4		 2gqgA-3iecA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		8 / 12 VAL A  67
ALA A  80
LYS A  82
MET A 104
VAL A 113
GLY A 135
LEU A 182
ALA A 192
 None
 0.67A 2gqgB-3iecA:
25.8		 2gqgB-3iecA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_A_SCKA902_1
(ACETYLCHOLINESTERASE)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		5 / 10 GLU A 199
ASN A 198
ASP A 232
GLU A 230
LEU A 295
 None
 1.10A 2ha6A-3iecA:
undetectable		 2ha6A-3iecA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 12 VAL A  67
ALA A  80
MET A 104
GLY A 135
ALA A 192
ASP A 193
 None
 0.82A 2hyyA-3iecA:
22.5		 2hyyA-3iecA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 12 VAL A  67
ALA A  80
MET A 104
GLY A 135
LEU A 182
ALA A 192
 None
 0.67A 2hyyA-3iecA:
22.5		 2hyyA-3iecA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 12 ALA A  80
GLU A 100
MET A 104
GLY A 135
LEU A 182
ALA A 192
 None
 0.84A 2hyyB-3iecA:
22.6		 2hyyB-3iecA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 12 VAL A  67
ALA A  80
MET A 104
GLY A 135
LEU A 182
ALA A 192
 None
 0.65A 2hyyB-3iecA:
22.6		 2hyyB-3iecA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 VAL A  67
ALA A  80
VAL A 113
GLY A 135
LEU A 182
ALA A 192
ASP A 193
 None
 0.85A 2hyyC-3iecA:
22.7		 2hyyC-3iecA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		9 / 12 VAL A  67
ALA A  80
LYS A  82
MET A 104
TYR A 131
GLY A 135
LEU A 182
ALA A 192
ASP A 193
 None
 0.88A 2oiqA-3iecA:
22.4		 2oiqA-3iecA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		8 / 12 VAL A  67
LYS A  82
GLU A 100
MET A 104
GLY A 135
LEU A 182
ALA A 192
ASP A 193
 None
 1.06A 2oiqA-3iecA:
22.4		 2oiqA-3iecA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		8 / 12 VAL A  67
ALA A  80
LYS A  82
MET A 104
VAL A 113
TYR A 131
ALA A 192
ASP A 193
 None
 0.76A 2pl0A-3iecA:
22.1		 2pl0A-3iecA:
27.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		8 / 12 VAL A  67
ALA A  80
LYS A  82
MET A 104
VAL A 113
TYR A 131
LEU A 182
ALA A 192
 None
 0.96A 2pl0A-3iecA:
22.1		 2pl0A-3iecA:
27.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		3 / 3 ARG A 292
GLN A 222
PRO A 218
 None
 0.87A 2qhfA-3iecA:
undetectable		 2qhfA-3iecA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		4 / 6 LEU A  97
ASP A 232
LYS A  96
GLU A 100
 None
 1.19A 2vn1B-3iecA:
undetectable		 2vn1B-3iecA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 GLY A  60
VAL A  67
ALA A  80
TYR A 131
GLY A 135
ALA A 192
ASP A 193
 None
 0.69A 2wgjA-3iecA:
22.4		 2wgjA-3iecA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		8 / 12 LYS A  57
ILE A  59
ALA A  80
LYS A  82
MET A 104
TYR A 131
GLY A 135
LEU A 182
 None
 0.72A 2y6oA-3iecA:
23.1		 2y6oA-3iecA:
28.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		5 / 11 LEU A 181
ASN A 111
LEU A 240
ILE A 239
LEU A 141
 None
 1.31A 3a50C-3iecA:
undetectable		 3a50C-3iecA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 12 ALA A  80
MET A 104
GLY A 135
HIS A 173
LEU A 182
ALA A 192
 None
 0.75A 3cs9A-3iecA:
22.4		 3cs9A-3iecA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		5 / 12 ALA A  80
MET A 104
GLY A 135
HIS A 173
ALA A 192
 None
 0.68A 3cs9B-3iecA:
22.6		 3cs9B-3iecA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 11 VAL A  67
ALA A  80
VAL A 113
TYR A 131
GLY A 135
LEU A 182
 None
 0.51A 3g0eA-3iecA:
21.3		 3g0eA-3iecA:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 ALA A  80
MET A 104
VAL A 113
TYR A 131
GLY A 135
LEU A 182
ALA A 192
 None
 0.58A 3g5dA-3iecA:
24.2		 3g5dA-3iecA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		8 / 12 ALA A  80
LYS A  82
MET A 104
VAL A 113
TYR A 131
GLY A 135
LEU A 182
ALA A 192
 None
 0.72A 3g5dB-3iecA:
24.1		 3g5dB-3iecA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		8 / 12 VAL A  67
ALA A  80
LYS A  82
MET A 104
VAL A 113
TYR A 131
LEU A 182
ALA A 192
 None
 0.65A 3g5dB-3iecA:
24.1		 3g5dB-3iecA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 VAL A  67
ALA A  80
MET A 104
ILE A 103
LEU A 182
ALA A 192
ASP A 193
 None
 1.47A 3gvuA-3iecA:
22.9		 3gvuA-3iecA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 VAL A  67
ALA A  80
MET A 104
VAL A 113
LEU A 182
ALA A 192
ASP A 193
 None
 0.80A 3gvuA-3iecA:
22.9		 3gvuA-3iecA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 12 VAL A  67
ALA A  80
MET A 104
GLY A 135
LEU A 182
ALA A 192
 None
 0.65A 3k5vA-3iecA:
17.0		 3k5vA-3iecA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 12 VAL A  67
ALA A  80
MET A 104
GLY A 135
LEU A 182
ALA A 192
 None
 0.66A 3k5vB-3iecA:
22.2		 3k5vB-3iecA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 12 VAL A  67
ALA A  80
MET A 104
GLY A 135
LEU A 182
ALA A 192
 None
 0.65A 3ms9B-3iecA:
15.4		 3ms9B-3iecA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 12 VAL A  67
ALA A  80
MET A 104
GLY A 135
LEU A 182
ALA A 192
 None
 0.62A 3mssB-3iecA:
22.3		 3mssB-3iecA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		8 / 12 VAL A  67
ALA A  80
LYS A  82
MET A 104
VAL A 113
TYR A 131
GLY A 135
LEU A 182
 None
 0.79A 3octA-3iecA:
23.0		 3octA-3iecA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 VAL A  67
ALA A  80
MET A 104
VAL A 113
TYR A 131
ALA A 192
ASP A 193
 None
 0.77A 3oezA-3iecA:
22.4		 3oezA-3iecA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 VAL A  67
MET A 104
VAL A 113
TYR A 131
GLY A 135
LEU A 182
ALA A 192
 None
 0.77A 3oezA-3iecA:
22.4		 3oezA-3iecA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		9 / 12 VAL A  67
ALA A  80
LYS A  82
GLU A 100
MET A 104
TYR A 131
LEU A 182
ALA A 192
ASP A 193
 None
 1.04A 3oezB-3iecA:
22.8		 3oezB-3iecA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 ALA A  80
MET A 104
VAL A 113
GLY A 135
HIS A 173
ALA A 192
ASP A 193
 None
 1.00A 3oxzA-3iecA:
22.2		 3oxzA-3iecA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 GLU A 100
MET A 104
VAL A 113
GLY A 135
HIS A 173
ALA A 192
ASP A 193
 None
 1.24A 3oxzA-3iecA:
22.2		 3oxzA-3iecA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 12 VAL A  67
ALA A  80
MET A 104
GLY A 135
LEU A 182
ALA A 192
 None
 0.66A 3pyyA-3iecA:
22.5		 3pyyA-3iecA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 VAL A  67
ALA A  80
MET A 104
VAL A 113
LEU A 182
ALA A 192
ASP A 193
 None
 0.80A 3pyyB-3iecA:
22.4		 3pyyB-3iecA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		9 / 12 VAL A  67
ALA A  80
LYS A  82
MET A 104
VAL A 113
TYR A 131
GLY A 135
LEU A 182
ALA A 192
 None
 0.76A 3qlgA-3iecA:
23.1		 3qlgA-3iecA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		8 / 12 VAL A  67
ALA A  80
MET A 104
VAL A 113
TYR A 131
GLY A 135
LEU A 182
ALA A 192
 None
 0.73A 3qlgB-3iecA:
23.6		 3qlgB-3iecA:
27.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 VAL A  67
ALA A  80
MET A 104
VAL A 113
TYR A 131
GLY A 135
LEU A 182
 None
 0.74A 3sxrB-3iecA:
24.7		 3sxrB-3iecA:
31.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 VAL A  67
ALA A  80
GLU A 100
MET A 104
VAL A 113
GLY A 135
LEU A 182
 None
 0.92A 3ue4B-3iecA:
25.2		 3ue4B-3iecA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 VAL A  67
ALA A  80
LYS A  82
LEU A 127
GLY A 135
ASP A 139
LEU A 182
 None
 0.82A 3ug2A-3iecA:
24.6		 3ug2A-3iecA:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		5 / 9 ILE A 103
LEU A 107
ILE A 112
TYR A 131
ILE A 191
 None
 0.81A 3zosA-3iecA:
22.0		 3zosA-3iecA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		5 / 9 ILE A 103
MET A 104
ILE A 112
TYR A 131
ILE A 191
 None
 0.97A 3zosA-3iecA:
22.0		 3zosA-3iecA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		5 / 9 ILE A 103
LEU A 107
ILE A 112
TYR A 131
ILE A 191
 None
 0.82A 3zosB-3iecA:
22.0		 3zosB-3iecA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		5 / 9 ILE A 103
MET A 104
ILE A 112
TYR A 131
ILE A 191
 None
 0.99A 3zosB-3iecA:
22.0		 3zosB-3iecA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 9 VAL A  67
ALA A  80
GLY A 135
LEU A 182
ALA A 192
ASP A 193
 None
 0.75A 4anqA-3iecA:
23.1		 4anqA-3iecA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		3 / 3 GLU A  78
TYR A 131
SER A 133
 None
 0.85A 4at0A-3iecA:
undetectable		 4at0A-3iecA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 GLU A 100
ILE A 103
MET A 104
TYR A 131
LEU A 182
ALA A 192
ASP A 193
 None
 1.30A 4bkjA-3iecA:
21.9		 4bkjA-3iecA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 VAL A  67
ALA A  80
MET A 104
TYR A 131
LEU A 182
ALA A 192
ASP A 193
 None
 0.99A 4bkjA-3iecA:
21.9		 4bkjA-3iecA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 12 ALA A  80
ILE A 103
MET A 104
LEU A 182
ALA A 192
ASP A 193
 None
 1.02A 4bkjB-3iecA:
21.9		 4bkjB-3iecA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 12 GLU A 100
ILE A 103
MET A 104
LEU A 182
ALA A 192
ASP A 193
 None
 1.06A 4bkjB-3iecA:
21.9		 4bkjB-3iecA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 12 VAL A  67
ALA A  80
MET A 104
LEU A 182
ALA A 192
ASP A 193
 None
 0.89A 4bkjB-3iecA:
21.9		 4bkjB-3iecA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		4 / 5 VAL A  67
ILE A 112
TYR A 131
ILE A 191
 None
 0.51A 4c8bA-3iecA:
22.6		 4c8bA-3iecA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 ALA A  80
LYS A  82
ILE A 112
HIS A 173
LEU A 182
ALA A 192
ASP A 193
 None
 0.83A 4c8bB-3iecA:
22.6		 4c8bB-3iecA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 11 GLY A  60
ALA A  80
TYR A 131
ALA A 132
GLY A 135
LEU A 182
 None
 0.85A 4ckiA-3iecA:
25.8		 4ckiA-3iecA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 11 GLY A  60
VAL A  67
ALA A  80
TYR A 131
ALA A 132
LEU A 182
 None
 0.76A 4ckiA-3iecA:
25.8		 4ckiA-3iecA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 GLU A 100
ILE A 103
MET A 104
VAL A 113
TYR A 131
LEU A 182
ALA A 192
 None
 0.97A 4csvA-3iecA:
23.1		 4csvA-3iecA:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 GLU A 100
MET A 104
VAL A 113
TYR A 131
LEU A 182
ALA A 192
ASP A 193
 None
 1.14A 4csvA-3iecA:
23.1		 4csvA-3iecA:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		8 / 12 VAL A  67
ALA A  80
ILE A 103
MET A 104
VAL A 113
TYR A 131
LEU A 182
ALA A 192
 None
 0.91A 4csvA-3iecA:
23.1		 4csvA-3iecA:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		8 / 12 VAL A  67
ALA A  80
MET A 104
VAL A 113
TYR A 131
LEU A 182
ALA A 192
ASP A 193
 None
 0.83A 4csvA-3iecA:
23.1		 4csvA-3iecA:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		8 / 12 GLY A  60
VAL A  67
ALA A  80
LEU A 115
LEU A 127
GLY A 135
GLU A 136
LEU A 182
 None
 0.53A 4ifgA-3iecA:
23.6		 4ifgA-3iecA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		5 / 10 PRO A 214
VAL A 238
TYR A 241
PHE A 250
SER A 247
 None
 1.30A 4mmdA-3iecA:
undetectable		 4mmdA-3iecA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		9 / 12 VAL A  67
ALA A  80
LYS A  82
VAL A 113
TYR A 131
GLY A 135
LEU A 182
ALA A 192
ASP A 193
 None
 0.91A 4mxyB-3iecA:
24.6		 4mxyB-3iecA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		9 / 12 VAL A  67
ALA A  80
VAL A 113
MET A 129
TYR A 131
GLY A 135
LEU A 182
ALA A 192
ASP A 193
 None
 0.89A 4mxyB-3iecA:
24.6		 4mxyB-3iecA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		9 / 12 VAL A  67
ALA A  80
LYS A  82
VAL A 113
TYR A 131
GLY A 135
LEU A 182
ALA A 192
ASP A 193
 None
 0.91A 4mxzB-3iecA:
24.6		 4mxzB-3iecA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		9 / 12 VAL A  67
ALA A  80
VAL A 113
MET A 129
TYR A 131
GLY A 135
LEU A 182
ALA A 192
ASP A 193
 None
 0.89A 4mxzB-3iecA:
24.6		 4mxzB-3iecA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA304_1
(TYROSINASE)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		4 / 5 ASN A  52
LEU A  74
HIS A  72
GLU A 353
 None
 1.38A 4p6sA-3iecA:
undetectable		 4p6sA-3iecA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		9 / 12 ILE A  59
ALA A  80
LYS A  82
GLU A 100
MET A 129
TYR A 131
LEU A 182
ALA A 192
ASP A 193
 None
 0.71A 4qmnA-3iecA:
29.4		 4qmnA-3iecA:
28.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		8 / 11 ILE A  59
ALA A  80
LYS A  82
GLU A 100
MET A 129
TYR A 131
LEU A 182
ASP A 193
 None
 0.86A 4qmsA-3iecA:
29.4		 4qmsA-3iecA:
28.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 ILE A  59
GLY A  60
VAL A  67
ALA A  80
MET A 129
TYR A 131
LEU A 182
 None
 0.57A 4qmzA-3iecA:
29.3		 4qmzA-3iecA:
28.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 ALA A  80
MET A 104
ALA A 132
HIS A 173
LEU A 182
ALA A 192
ASP A 193
 None
 0.95A 4tyjA-3iecA:
22.8		 4tyjA-3iecA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 12 ALA A  80
MET A 104
CYH A 166
HIS A 173
LEU A 182
ALA A 192
 None
 1.38A 4tyjA-3iecA:
22.8		 4tyjA-3iecA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 GLU A 100
MET A 104
ALA A 132
HIS A 173
LEU A 182
ALA A 192
ASP A 193
 None
 1.18A 4tyjA-3iecA:
22.8		 4tyjA-3iecA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 12 GLU A 100
MET A 104
CYH A 166
HIS A 173
LEU A 182
ALA A 192
 None
 1.31A 4tyjA-3iecA:
22.8		 4tyjA-3iecA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		4 / 6 VAL A  67
LYS A  82
ILE A 112
ILE A 191
 None
 0.53A 4tyjA-3iecA:
22.8		 4tyjA-3iecA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 10 LEU A 107
ILE A 112
VAL A 113
TYR A 131
ARG A 174
ILE A 191
 None
 0.83A 4u0iA-3iecA:
21.9		 4u0iA-3iecA:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 10 VAL A  67
LEU A 107
ILE A 112
VAL A 113
TYR A 131
ILE A 191
 None
 0.70A 4u0iA-3iecA:
21.9		 4u0iA-3iecA:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		8 / 11 VAL A  67
ALA A  80
TYR A 131
GLY A 135
ASN A 180
LEU A 182
ALA A 192
ASP A 193
 None
 0.74A 4u5jA-3iecA:
25.0		 4u5jA-3iecA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 9 VAL A  67
ALA A  80
TYR A 131
GLY A 135
LEU A 182
ASP A 193
 None
 0.75A 4u5jB-3iecA:
24.5		 4u5jB-3iecA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		5 / 7 LYS A  82
MET A 104
ALA A 132
ARG A 174
ILE A 191
 None
 0.80A 4uxqA-3iecA:
22.3		 4uxqA-3iecA:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		5 / 7 VAL A  67
LYS A  82
MET A 104
ALA A 132
ILE A 191
 None
 0.83A 4uxqA-3iecA:
22.3		 4uxqA-3iecA:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 12 ALA A  80
MET A 104
ALA A 132
HIS A 173
ALA A 192
ASP A 193
 None
 0.95A 4v01A-3iecA:
22.5		 4v01A-3iecA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 12 GLU A 100
MET A 104
ALA A 132
HIS A 173
ALA A 192
ASP A 193
 None
 1.22A 4v01A-3iecA:
22.5		 4v01A-3iecA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 12 ALA A  80
MET A 104
ALA A 132
HIS A 173
ALA A 192
ASP A 193
 None
 0.93A 4v01B-3iecA:
22.5		 4v01B-3iecA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 12 GLU A 100
MET A 104
ALA A 132
HIS A 173
ALA A 192
ASP A 193
 None
 1.17A 4v01B-3iecA:
22.5		 4v01B-3iecA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 VAL A  67
ALA A  80
ALA A 132
HIS A 173
ALA A 192
ASP A 193
GLY A 195
 None
 1.35A 4v04A-3iecA:
22.3		 4v04A-3iecA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		4 / 8 LYS A  82
TYR A 131
LEU A 182
ILE A 191
 None
 0.50A 4v04A-3iecA:
22.3		 4v04A-3iecA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		5 / 8 MET A 104
TYR A 131
ARG A 174
LEU A 182
ILE A 191
 None
 0.90A 4v04A-3iecA:
22.3		 4v04A-3iecA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 10 VAL A  67
LYS A  82
MET A 104
TYR A 131
LEU A 182
ILE A 191
 None
 0.72A 4v04B-3iecA:
22.3		 4v04B-3iecA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		5 / 12 ALA A  80
ALA A 132
HIS A 173
ALA A 192
ASP A 193
 None
 0.91A 4v04B-3iecA:
22.3		 4v04B-3iecA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 VAL A  67
ALA A  80
LYS A  82
GLY A 135
ASN A 180
LEU A 182
ALA A 192
 None
 0.88A 4wa9B-3iecA:
24.5		 4wa9B-3iecA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 VAL A  67
ALA A  80
MET A 104
VAL A 113
GLY A 135
LEU A 182
ALA A 192
 None
 0.76A 4xeyA-3iecA:
24.9		 4xeyA-3iecA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 ALA A  80
MET A 104
VAL A 113
TYR A 131
GLY A 135
LEU A 182
ALA A 192
 None
 0.50A 4xliA-3iecA:
25.6		 4xliA-3iecA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		8 / 12 ALA A  80
LYS A  82
MET A 104
VAL A 113
TYR A 131
GLY A 135
LEU A 182
ALA A 192
 None
 0.62A 4xliB-3iecA:
26.0		 4xliB-3iecA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		8 / 12 VAL A  67
ALA A  80
LYS A  82
MET A 104
TYR A 131
GLY A 135
LEU A 182
ALA A 192
 None
 0.73A 5bvwA-3iecA:
22.0		 5bvwA-3iecA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 12 ILE A  59
ALA A  80
LYS A  82
TYR A 131
GLY A 135
LEU A 182
 None
 0.72A 5i9xA-3iecA:
23.4		 5i9xA-3iecA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 12 GLY A  60
VAL A  67
ALA A  80
VAL A 113
LEU A 182
ALA A 192
 None
 0.70A 5l2iA-3iecA:
7.6		 5l2iA-3iecA:
27.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		8 / 11 GLY A  60
VAL A  67
ALA A  80
VAL A 113
TYR A 131
ALA A 132
GLU A 136
LEU A 182
 None
 0.51A 5lvnA-3iecA:
30.9		 5lvnA-3iecA:
31.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		8 / 12 ILE A  59
GLY A  60
VAL A  67
ALA A  80
LYS A  82
TYR A 131
GLY A 135
GLU A 136
 None
 0.71A 5mafA-3iecA:
36.1		 5mafA-3iecA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		8 / 12 ILE A  59
GLY A  60
VAL A  67
LYS A  82
GLU A 100
TYR A 131
GLY A 135
GLU A 136
 None
 0.89A 5mafA-3iecA:
36.1		 5mafA-3iecA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		5 / 12 ALA A  80
MET A 104
VAL A 113
ALA A 192
ASP A 193
 None
 0.78A 5mo4A-3iecA:
19.6		 5mo4A-3iecA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		5 / 12 ALA A  80
MET A 104
VAL A 113
HIS A 173
ALA A 192
 None
 0.72A 5mo4A-3iecA:
19.6		 5mo4A-3iecA:
17.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 10 VAL A  67
ALA A  80
VAL A 113
MET A 129
TYR A 131
LEU A 182
 None
 0.75A 5n3hA-3iecA:
29.4		 5n3hA-3iecA:
32.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 3iec CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Helicobacter
pylori;
Homo
sapiens) 		5 / 12 LEU A 220
GLY A 211
LYS E 955
LEU A 258
LEU A 255
 None
 1.34A 5nwvA-3iecA:
undetectable		 5nwvA-3iecA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 12 LEU A  69
ALA A  80
MET A 104
VAL A 113
GLY A 135
LEU A 182
 None
 0.60A 5te0A-3iecA:
27.0		 5te0A-3iecA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 12 LEU A  69
GLU A 100
MET A 104
VAL A 113
GLY A 135
LEU A 182
 None
 0.69A 5te0A-3iecA:
27.0		 5te0A-3iecA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 12 ILE A  59
GLY A  60
ALA A  80
TYR A 131
GLY A 135
ASP A 193
 None
 0.85A 5vc3A-3iecA:
22.9		 5vc3A-3iecA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		6 / 12 ILE A  59
GLY A  60
GLU A 100
TYR A 131
GLY A 135
ASP A 193
 None
 1.00A 5vc3A-3iecA:
22.9		 5vc3A-3iecA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		4 / 4 VAL A  67
LYS A  82
VAL A 113
ASN A 180
 None
 0.78A 5vc3A-3iecA:
22.9		 5vc3A-3iecA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 VAL A  67
ALA A  80
MET A 104
TYR A 131
ALA A 132
GLY A 135
ALA A 192
 None
 0.71A 5zv2A-3iecA:
22.3		 5zv2A-3iecA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		3 / 3 LYS A  82
LEU A 182
ASP A 193
 None
 0.84A 5zv2A-3iecA:
22.3		 5zv2A-3iecA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 VAL A  67
ALA A  80
LYS A  82
MET A 104
ALA A 132
GLY A 135
ALA A 192
 None
 0.71A 5zv2B-3iecA:
22.5		 5zv2B-3iecA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 VAL A  67
ALA A  80
LYS A  82
MET A 104
VAL A 113
ALA A 192
ASP A 193
 None
 0.68A 6hd4A-3iecA:
22.3		 6hd4A-3iecA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 VAL A  67
ALA A  80
LYS A  82
MET A 104
VAL A 113
LEU A 182
ALA A 192
 None
 0.73A 6hd4A-3iecA:
22.3		 6hd4A-3iecA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 VAL A  67
ALA A  80
LYS A  82
MET A 104
VAL A 113
ALA A 192
ASP A 193
 None
 0.74A 6hd4B-3iecA:
22.1		 6hd4B-3iecA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 VAL A  67
ALA A  80
LYS A  82
MET A 104
VAL A 113
LEU A 182
ALA A 192
 None
 0.77A 6hd4B-3iecA:
22.1		 6hd4B-3iecA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 VAL A  67
ALA A  80
LYS A  82
MET A 104
VAL A 113
ALA A 192
ASP A 193
 None
 0.67A 6hd6A-3iecA:
22.2		 6hd6A-3iecA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 VAL A  67
ALA A  80
LYS A  82
MET A 104
VAL A 113
LEU A 182
ALA A 192
 None
 0.72A 6hd6A-3iecA:
22.2		 6hd6A-3iecA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens) 		7 / 12 VAL A  67
ALA A  80
LYS A  82
MET A 104
VAL A 113
LEU A 182
ASP A 193
 None
 0.90A 6hd6B-3iecA:
22.0		 6hd6B-3iecA:
13.61