SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ied'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 3ied HEAT SHOCK PROTEIN
(Plasmodium
falciparum) 		5 / 12 ILE A 200
LEU A 305
PRO A 191
LEU A 318
ASN A 256
 None
 1.39A 1mrlB-3iedA:
undetectable
1mrlC-3iedA:
undetectable		 1mrlB-3iedA:
24.20
1mrlC-3iedA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 3ied HEAT SHOCK PROTEIN
(Plasmodium
falciparum) 		4 / 7 LEU A 303
ILE A 301
ASN A 133
PHE A 248
 None
None
AN2  A 401 (-3.0A)
None
 0.88A 2opxA-3iedA:
undetectable		 2opxA-3iedA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3ied HEAT SHOCK PROTEIN
(Plasmodium
falciparum) 		4 / 8 SER A 255
MET A 112
VAL A 116
PHE A 248
 None
 1.26A 2wekA-3iedA:
undetectable		 2wekA-3iedA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 3ied HEAT SHOCK PROTEIN
(Plasmodium
falciparum) 		5 / 9 LEU A 198
LEU A 318
GLU A 311
GLU A 320
VAL A 254
 None
 1.28A 3tmzA-3iedA:
undetectable		 3tmzA-3iedA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3ied HEAT SHOCK PROTEIN
(Plasmodium
falciparum) 		4 / 8 SER A 210
MET A 207
ILE A 213
GLU A 211
 None
AN2  A 401 (-3.6A)
None
None
 1.10A 4cx7A-3iedA:
undetectable
4cx7B-3iedA:
undetectable		 4cx7A-3iedA:
19.54
4cx7B-3iedA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3ied HEAT SHOCK PROTEIN
(Plasmodium
falciparum) 		4 / 8 SER A 210
MET A 207
ILE A 213
GLU A 211
 None
AN2  A 401 (-3.6A)
None
None
 1.18A 4cx7C-3iedA:
undetectable
4cx7D-3iedA:
undetectable		 4cx7C-3iedA:
19.54
4cx7D-3iedA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ied HEAT SHOCK PROTEIN
(Plasmodium
falciparum) 		3 / 3 GLY A 223
VAL A 108
MET A 112
 None
 0.54A 5ycpA-3iedA:
undetectable		 5ycpA-3iedA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3ied HEAT SHOCK PROTEIN
(Plasmodium
falciparum) 		3 / 3 LEU A 212
GLY A 217
PHE A 252
 None
 0.62A 6exiC-3iedA:
undetectable		 6exiC-3iedA:
16.10