SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ieg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EJ3_A_GBNA2414_1 (BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE)	3ieg	DNAJ HOMOLOG SUBFAMILY C MEMBER 3 (Mus musculus)	4 / 8	GLY A 167 THR A 171 ALA A 172 ALA A 173	None	0.56A	2ej3A-3iegA: undetectable	2ej3A-3iegA: 21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IZQ_D_DVAD6_0 (GRAMICIDIN D)	3ieg	DNAJ HOMOLOG SUBFAMILY C MEMBER 3 (Mus musculus)	3 / 3	TRP A 186 ALA A 188 VAL A 185	None	0.98A	2izqC-3iegA: undetectable 2izqD-3iegA: undetectable	2izqC-3iegA: 4.81 2izqD-3iegA: 4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AX9_B_SALB1340_1 (XANTHINE DEHYDROGENASE/OXIDAS E)	3ieg	DNAJ HOMOLOG SUBFAMILY C MEMBER 3 (Mus musculus)	4 / 8	LEU A 57 THR A 79 ALA A 89 ALA A 90	None	0.92A	3ax9B-3iegA: undetectable	3ax9B-3iegA: 14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L8L_B_DVAB6_0 (GRAMICIDIN D)	3ieg	DNAJ HOMOLOG SUBFAMILY C MEMBER 3 (Mus musculus)	3 / 3	TRP A 186 ALA A 188 VAL A 185	None	0.98A	3l8lA-3iegA: undetectable 3l8lB-3iegA: undetectable	3l8lA-3iegA: 4.81 3l8lB-3iegA: 5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WRY_A_URFA302_1 (URACIL-DNA GLYCOSYLASE)	3ieg	DNAJ HOMOLOG SUBFAMILY C MEMBER 3 (Mus musculus)	4 / 8	GLY A 112 GLN A 110 PHE A 128 HIS A 113	None	1.03A	4wryA-3iegA: undetectable	4wryA-3iegA: 19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WRZ_A_URFA302_1 (URACIL-DNA GLYCOSYLASE)	3ieg	DNAJ HOMOLOG SUBFAMILY C MEMBER 3 (Mus musculus)	4 / 8	GLY A 112 GLN A 110 PHE A 128 HIS A 113	None	0.97A	4wrzA-3iegA: undetectable	4wrzA-3iegA: 19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Y4D_A_CFFA411_1 (ENDOTHIAPEPSIN)	3ieg	DNAJ HOMOLOG SUBFAMILY C MEMBER 3 (Mus musculus)	4 / 6	ASP A 220 LEU A 251 ILE A 228 PHE A 225	None	1.24A	4y4dA-3iegA: undetectable	4y4dA-3iegA: 19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FSE_C_HQEC1583_1 (UREASE SUBUNIT ALPHA)	3ieg	DNAJ HOMOLOG SUBFAMILY C MEMBER 3 (Mus musculus)	4 / 5	ILE A 174 ARG A 194 CYH A 197 GLU A 196	None	1.33A	5fseC-3iegA: undetectable	5fseC-3iegA: 21.22

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2EJ3_A_GBNA2414_1","BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE","3ieg","DNAJ HOMOLOG SUBFAMILY C MEMBER 3","Mus musculus",4,"GLY A 167;THR A 171;ALA A 172;ALA A 173","None","0.56A","2ej3A-3iegA:undetectable","2ej3A-3iegA:21.60"],["2IZQ_D_DVAD6_0","GRAMICIDIN D","3ieg","DNAJ HOMOLOG SUBFAMILY C MEMBER 3","Mus musculus",3,"TRP A 186;ALA A 188;VAL A 185","None","0.98A","2izqC-3iegA:undetectable;2izqD-3iegA:undetectable","2izqC-3iegA:4.81;2izqD-3iegA:4.81"],["3AX9_B_SALB1340_1","XANTHINE DEHYDROGENASE\/OXIDASE","3ieg","DNAJ HOMOLOG SUBFAMILY C MEMBER 3","Mus musculus",4,"LEU A  57;THR A  79;ALA A  89;ALA A  90","None","0.92A","3ax9B-3iegA:undetectable","3ax9B-3iegA:14.56"],["3L8L_B_DVAB6_0","GRAMICIDIN D","3ieg","DNAJ HOMOLOG SUBFAMILY C MEMBER 3","Mus musculus",3,"TRP A 186;ALA A 188;VAL A 185","None","0.98A","3l8lA-3iegA:undetectable;3l8lB-3iegA:undetectable","3l8lA-3iegA:4.81;3l8lB-3iegA:5.29"],["4WRY_A_URFA302_1","URACIL-DNA GLYCOSYLASE","3ieg","DNAJ HOMOLOG SUBFAMILY C MEMBER 3","Mus musculus",4,"GLY A 112;GLN A 110;PHE A 128;HIS A 113","None","1.03A","4wryA-3iegA:undetectable","4wryA-3iegA:19.83"],["4WRZ_A_URFA302_1","URACIL-DNA GLYCOSYLASE","3ieg","DNAJ HOMOLOG SUBFAMILY C MEMBER 3","Mus musculus",4,"GLY A 112;GLN A 110;PHE A 128;HIS A 113","None","0.97A","4wrzA-3iegA:undetectable","4wrzA-3iegA:19.83"],["4Y4D_A_CFFA411_1","ENDOTHIAPEPSIN","3ieg","DNAJ HOMOLOG SUBFAMILY C MEMBER 3","Mus musculus",4,"ASP A 220;LEU A 251;ILE A 228;PHE A 225","None","1.24A","4y4dA-3iegA:undetectable","4y4dA-3iegA:19.74"],["5FSE_C_HQEC1583_1","UREASE SUBUNIT ALPHA","3ieg","DNAJ HOMOLOG SUBFAMILY C MEMBER 3","Mus musculus",4,"ILE A 174;ARG A 194;CYH A 197;GLU A 196","None","1.33A","5fseC-3iegA:undetectable","5fseC-3iegA:21.22"]]