SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ieh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		4 / 7 GLU A 170
SER A  21
PHE A 252
ALA A 248
 None
 0.97A 1fo4B-3iehA:
undetectable		 1fo4B-3iehA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		4 / 7 SER A  67
ALA A 159
SER A  63
ALA A  61
 None
 0.94A 1k5qA-3iehA:
undetectable
1k5qB-3iehA:
undetectable		 1k5qA-3iehA:
20.42
1k5qB-3iehA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		5 / 12 GLU A  77
HIS A  75
ALA A  72
GLY A 112
GLY A  76
 None
ZN  A 276 ( 3.2A)
None
None
None
 1.12A 1x1aA-3iehA:
undetectable		 1x1aA-3iehA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		4 / 8 ASP A 171
TYR A 180
TYR A 178
HIS A 224
 None
UNL  A 277 (-3.9A)
None
UNL  A 277 ( 4.9A)
 1.34A 2ha2B-3iehA:
undetectable		 2ha2B-3iehA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		4 / 8 ILE A 165
GLY A 241
LEU A 269
PHE A 266
 None
 0.75A 2vctA-3iehA:
undetectable		 2vctA-3iehA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		4 / 8 ILE A 165
GLY A 241
LEU A 269
PHE A 266
 None
 0.72A 2vctB-3iehA:
undetectable		 2vctB-3iehA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		4 / 8 ILE A 165
GLY A 241
LEU A 269
PHE A 266
 None
 0.74A 2vctC-3iehA:
undetectable		 2vctC-3iehA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		4 / 7 ILE A 165
GLY A 241
LEU A 269
PHE A 266
 None
 0.71A 2vctD-3iehA:
undetectable		 2vctD-3iehA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		5 / 12 THR A 246
ALA A 262
LEU A 195
ALA A 242
GLY A  73
 None
 1.02A 2ve3A-3iehA:
undetectable		 2ve3A-3iehA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		3 / 3 GLU A 245
HIS A  75
GLU A  78
 ZN  A 276 ( 4.4A)
ZN  A 276 ( 3.2A)
ZN  A 276 (-2.0A)
 0.85A 2x45B-3iehA:
undetectable		 2x45B-3iehA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		3 / 3 GLU A 245
HIS A  75
GLU A  78
 ZN  A 276 ( 4.4A)
ZN  A 276 ( 3.2A)
ZN  A 276 (-2.0A)
 0.88A 2x45C-3iehA:
undetectable		 2x45C-3iehA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		5 / 8 VAL A  48
GLY A 112
THR A 111
GLY A  73
GLU A 124
 None
 1.24A 3aruA-3iehA:
undetectable		 3aruA-3iehA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		4 / 8 LEU A 233
SER A 236
ALA A 160
ALA A 159
 None
 0.88A 3ax9B-3iehA:
undetectable		 3ax9B-3iehA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		4 / 6 HIS A 153
GLN A  57
LEU A  45
LEU A  55
 GOL  A 279 (-4.5A)
None
None
None
 1.08A 3bgdA-3iehA:
undetectable		 3bgdA-3iehA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		3 / 3 PRO A 247
ASP A 171
GLU A 176
 None
 0.82A 3v4tC-3iehA:
undetectable		 3v4tC-3iehA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		5 / 9 LEU A  85
LEU A  69
GLN A  57
TYR A  56
LEU A  31
 None
 1.14A 4ltwA-3iehA:
undetectable		 4ltwA-3iehA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		3 / 3 PRO A 106
LEU A 105
HIS A 153
 None
None
GOL  A 279 (-4.5A)
 0.67A 4pevA-3iehA:
undetectable		 4pevA-3iehA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		4 / 5 GLY A 112
THR A 111
HIS A 117
GLY A 123
 None
 0.97A 4v20A-3iehA:
undetectable		 4v20A-3iehA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		4 / 8 LEU A  69
THR A 167
LEU A 150
LEU A 157
 None
 0.72A 4z90F-3iehA:
undetectable
4z90G-3iehA:
undetectable
4z90H-3iehA:
undetectable
4z90I-3iehA:
undetectable
4z90J-3iehA:
undetectable		 4z90F-3iehA:
22.12
4z90G-3iehA:
22.12
4z90H-3iehA:
22.12
4z90I-3iehA:
22.12
4z90J-3iehA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		5 / 12 GLU A 124
LEU A  45
LEU A 105
PRO A 126
ARG A 128
 None
 1.31A 5hnxB-3iehA:
undetectable		 5hnxB-3iehA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		3 / 3 ALA A 258
GLN A 250
THR A 246
 None
PGE  A 288 ( 3.5A)
None
 0.61A 5n0oA-3iehA:
undetectable		 5n0oA-3iehA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		4 / 4 SER A  79
ALA A  80
GLN A 250
THR A 246
 None
None
PGE  A 288 ( 3.5A)
None
 1.48A 5n0rA-3iehA:
undetectable		 5n0rA-3iehA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		4 / 4 SER A  79
ALA A  80
GLN A 250
THR A 246
 None
None
PGE  A 288 ( 3.5A)
None
 1.48A 5n0sA-3iehA:
1.5		 5n0sA-3iehA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		4 / 4 SER A  79
ALA A  80
GLN A 250
THR A 246
 None
None
PGE  A 288 ( 3.5A)
None
 1.48A 5n0wA-3iehA:
undetectable		 5n0wA-3iehA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		4 / 5 GLY A 164
ASP A 163
ARG A 162
GLN A  57
 None
 1.31A 5zrfB-3iehA:
undetectable		 5zrfB-3iehA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		4 / 7 HIS A 169
THR A 167
HIS A 117
GLU A  78
 ZN  A 276 (-3.5A)
None
None
ZN  A 276 (-2.0A)
 1.19A 6mn4E-3iehA:
undetectable		 6mn4E-3iehA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		4 / 6 ASP A 212
TYR A 180
GLU A 245
ASP A 171
 None
UNL  A 277 (-3.9A)
ZN  A 276 ( 4.4A)
None
 1.06A 6mn5A-3iehA:
undetectable		 6mn5A-3iehA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		4 / 7 ASP A 212
TYR A 180
GLU A 245
ASP A 171
 None
UNL  A 277 (-3.9A)
ZN  A 276 ( 4.4A)
None
 1.03A 6mn5B-3iehA:
undetectable		 6mn5B-3iehA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		4 / 6 ASP A 212
TYR A 180
GLU A 245
ASP A 171
 None
UNL  A 277 (-3.9A)
ZN  A 276 ( 4.4A)
None
 1.01A 6mn5C-3iehA:
undetectable		 6mn5C-3iehA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3ieh PUTATIVE
METALLOPEPTIDASE
(Shewanella
baltica) 		4 / 7 ASP A 212
TYR A 180
GLU A 245
ASP A 171
 None
UNL  A 277 (-3.9A)
ZN  A 276 ( 4.4A)
None
 1.05A 6mn5E-3iehA:
undetectable		 6mn5E-3iehA:
13.86