SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iey'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 3iey NEQ261
TRNA-SPLICING
ENDONUCLEASE
(Nanoarchaeum
equitans) 		5 / 12 LEU A 136
GLY A 138
VAL A 140
ARG B 150
LEU A  73
 None
 1.10A 1nhzA-3ieyA:
undetectable		 1nhzA-3ieyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3iey NEQ261
TRNA-SPLICING
ENDONUCLEASE
(Nanoarchaeum
equitans) 		5 / 12 ALA A 128
VAL A 149
ILE B 134
LEU B 132
PHE A 121
 None
 1.22A 2qk8A-3ieyA:
undetectable		 2qk8A-3ieyA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3iey TRNA-SPLICING
ENDONUCLEASE
NEQ261
(Nanoarchaeum
equitans;
Nanoarchaeum
equitans) 		4 / 5 PHE B  83
PHE B 130
LEU B 132
PHE A 118
 None
 1.29A 2y69C-3ieyB:
undetectable
2y69J-3ieyB:
undetectable		 2y69C-3ieyB:
21.43
2y69J-3ieyB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3iey TRNA-SPLICING
ENDONUCLEASE
NEQ261
(Nanoarchaeum
equitans;
Nanoarchaeum
equitans) 		4 / 5 PHE B  83
PHE B 130
LEU B 132
PHE A 118
 None
 1.31A 2y69P-3ieyB:
undetectable
2y69W-3ieyB:
undetectable		 2y69P-3ieyB:
21.43
2y69W-3ieyB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3iey TRNA-SPLICING
ENDONUCLEASE
NEQ261
(Nanoarchaeum
equitans;
Nanoarchaeum
equitans) 		4 / 5 PHE B  83
PHE B 130
LEU B 132
PHE A 118
 None
 1.28A 3abmC-3ieyB:
undetectable
3abmJ-3ieyB:
undetectable		 3abmC-3ieyB:
21.43
3abmJ-3ieyB:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3iey TRNA-SPLICING
ENDONUCLEASE
NEQ261
(Nanoarchaeum
equitans;
Nanoarchaeum
equitans) 		4 / 5 PHE B  83
PHE B 130
LEU B 132
PHE A 118
 None
 1.27A 3abmP-3ieyB:
undetectable
3abmW-3ieyB:
undetectable		 3abmP-3ieyB:
21.43
3abmW-3ieyB:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3iey TRNA-SPLICING
ENDONUCLEASE
NEQ261
(Nanoarchaeum
equitans;
Nanoarchaeum
equitans) 		4 / 5 PHE B  83
PHE B 130
LEU B 132
PHE A 118
 None
 1.32A 3ag3C-3ieyB:
undetectable
3ag3J-3ieyB:
undetectable		 3ag3C-3ieyB:
21.43
3ag3J-3ieyB:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 3iey NEQ261
TRNA-SPLICING
ENDONUCLEASE
(Nanoarchaeum
equitans) 		5 / 10 ALA A 128
VAL A 149
ILE B 134
LEU B 132
PHE A 121
 None
 1.22A 3jw5B-3ieyA:
undetectable		 3jw5B-3ieyA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3iey NEQ261
TRNA-SPLICING
ENDONUCLEASE
(Nanoarchaeum
equitans) 		5 / 9 LEU B 116
ILE A 147
ILE B 134
GLU B  62
GLU A 120
 None
 1.26A 5igzA-3ieyB:
undetectable		 5igzA-3ieyB:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3iey TRNA-SPLICING
ENDONUCLEASE
NEQ261
(Nanoarchaeum
equitans;
Nanoarchaeum
equitans) 		4 / 5 PHE B  83
PHE B 130
LEU B 132
PHE A 118
 None
 1.27A 5wauc-3ieyB:
undetectable
5wauj-3ieyB:
undetectable		 5wauc-3ieyB:
21.43
5wauj-3ieyB:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3iey TRNA-SPLICING
ENDONUCLEASE
(Nanoarchaeum
equitans) 		4 / 5 LEU A  17
TYR A  24
LEU A  31
GLU A  30
 None
 1.27A 5weaA-3ieyA:
undetectable		 5weaA-3ieyA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3iey TRNA-SPLICING
ENDONUCLEASE
NEQ261
(Nanoarchaeum
equitans;
Nanoarchaeum
equitans) 		4 / 5 PHE B  83
PHE B 130
LEU B 132
PHE A 118
 None
 1.27A 5xdqC-3ieyB:
undetectable
5xdqJ-3ieyB:
undetectable		 5xdqC-3ieyB:
21.43
5xdqJ-3ieyB:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3iey TRNA-SPLICING
ENDONUCLEASE
NEQ261
(Nanoarchaeum
equitans;
Nanoarchaeum
equitans) 		4 / 5 PHE B  83
PHE B 130
LEU B 132
PHE A 118
 None
 1.27A 5xdqP-3ieyB:
undetectable
5xdqW-3ieyB:
undetectable		 5xdqP-3ieyB:
21.43
5xdqW-3ieyB:
17.31