SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3if8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)
3if8 PROTEIN ZWILCH
HOMOLOG
PROTEIN ZWILCH
HOMOLOG

(Homo
sapiens;
Homo
sapiens)
5 / 11 CYH B 495
LEU B 488
LEU A 208
LEU B 512
ILE A 225
None
1.10A 1ee2A-3if8B:
undetectable
1ee2A-3if8B:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)
3if8 PROTEIN ZWILCH
HOMOLOG
PROTEIN ZWILCH
HOMOLOG

(Homo
sapiens;
Homo
sapiens)
5 / 11 CYH B 495
LEU B 488
LEU A 208
LEU B 512
ILE A 225
None
1.10A 1ee2B-3if8B:
undetectable
1ee2B-3if8B:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
3if8 PROTEIN ZWILCH
HOMOLOG

(Homo
sapiens)
5 / 8 LEU A 275
PHE B 348
LEU A 303
MET B 356
SER B 359
None
1.47A 1wrlC-3if8A:
undetectable
1wrlD-3if8A:
undetectable
1wrlC-3if8A:
14.67
1wrlD-3if8A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)
3if8 PROTEIN ZWILCH
HOMOLOG

(Homo
sapiens)
4 / 5 LEU B 467
LEU B 504
CYH B 495
THR B 492
None
1.16A 2oaxD-3if8B:
undetectable
2oaxD-3if8B:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)
3if8 PROTEIN ZWILCH
HOMOLOG

(Homo
sapiens)
3 / 3 PHE B 348
SER B 376
LEU B 372
None
0.83A 2w1bA-3if8B:
undetectable
2w1bA-3if8B:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)
3if8 PROTEIN ZWILCH
HOMOLOG

(Homo
sapiens)
4 / 8 ILE A 110
LEU A 109
THR A 148
VAL A  64
None
0.79A 3dcjB-3if8A:
undetectable
3dcjB-3if8A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)
3if8 PROTEIN ZWILCH
HOMOLOG

(Homo
sapiens)
4 / 7 TYR B 432
GLU B 472
LEU B 428
LYS B 427
None
1.21A 3k8mB-3if8B:
undetectable
3k8mB-3if8B:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)
3if8 PROTEIN ZWILCH
HOMOLOG

(Homo
sapiens)
4 / 6 SER B 586
LEU A  55
ILE B 542
LEU A 151
None
0.94A 3kk6A-3if8B:
3.4
3kk6A-3if8B:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)
3if8 PROTEIN ZWILCH
HOMOLOG

(Homo
sapiens)
3 / 3 LEU B 428
ASP B 431
TYR B 432
None
0.42A 4qc6B-3if8B:
undetectable
4qc6B-3if8B:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJD_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)
3if8 PROTEIN ZWILCH
HOMOLOG

(Homo
sapiens)
5 / 9 LEU A 167
LEU A 155
ILE A  63
ILE A 110
LEU A  51
None
1.17A 5ljdA-3if8A:
undetectable
5ljdA-3if8A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)
3if8 PROTEIN ZWILCH
HOMOLOG
PROTEIN ZWILCH
HOMOLOG

(Homo
sapiens;
Homo
sapiens)
4 / 5 VAL B 514
ASN A 250
ASP A 228
LEU A 227
None
1.03A 5m0iB-3if8B:
undetectable
5m0iB-3if8B:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)
3if8 PROTEIN ZWILCH
HOMOLOG

(Homo
sapiens)
3 / 3 LYS B 530
TRP B 531
SER B 549
None
1.33A 5nwwA-3if8B:
undetectable
5nwwA-3if8B:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)
3if8 PROTEIN ZWILCH
HOMOLOG
PROTEIN ZWILCH
HOMOLOG

(Homo
sapiens;
Homo
sapiens)
3 / 3 VAL B 461
ALA A 276
GLN B 465
None
0.68A 6gb9A-3if8B:
undetectable
6gb9A-3if8B:
19.96