SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ifc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 3ifc FRUCTOSE-1,6-BISPHOS
PHATASE ISOZYME 2
(Homo
sapiens) 		4 / 8 GLY A 178
GLY A 180
TYR A 286
VAL A 173
 None
 0.87A 1dbbH-3ifcA:
undetectable
1dbbL-3ifcA:
undetectable		 1dbbH-3ifcA:
22.54
1dbbL-3ifcA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 3ifc FRUCTOSE-1,6-BISPHOS
PHATASE ISOZYME 2
(Homo
sapiens) 		5 / 12 GLY A 319
GLY A 260
GLY A 259
VAL A 324
ASN A 282
 None
 0.77A 1n2xB-3ifcA:
undetectable		 1n2xB-3ifcA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3ifc FRUCTOSE-1,6-BISPHOS
PHATASE ISOZYME 2
(Homo
sapiens) 		4 / 7 GLY A 133
ARG A  49
GLY A 168
ALA A 165
 None
 0.71A 5e26A-3ifcA:
undetectable
5e26B-3ifcA:
undetectable		 5e26A-3ifcA:
23.00
5e26B-3ifcA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3ifc FRUCTOSE-1,6-BISPHOS
PHATASE ISOZYME 2
(Homo
sapiens) 		4 / 7 ALA A 165
GLY A 133
ARG A  49
GLY A 168
 None
 0.73A 5e26A-3ifcA:
undetectable
5e26B-3ifcA:
undetectable		 5e26A-3ifcA:
23.00
5e26B-3ifcA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3ifc FRUCTOSE-1,6-BISPHOS
PHATASE ISOZYME 2
(Homo
sapiens) 		4 / 7 GLY A 133
ARG A  49
GLY A 168
ALA A 165
 None
 0.74A 5e26C-3ifcA:
undetectable
5e26D-3ifcA:
undetectable		 5e26C-3ifcA:
23.00
5e26D-3ifcA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3ifc FRUCTOSE-1,6-BISPHOS
PHATASE ISOZYME 2
(Homo
sapiens) 		4 / 8 ALA A 165
GLY A 133
ARG A  49
GLY A 168
 None
 0.74A 5e26C-3ifcA:
undetectable
5e26D-3ifcA:
undetectable		 5e26C-3ifcA:
23.00
5e26D-3ifcA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 3ifc FRUCTOSE-1,6-BISPHOS
PHATASE ISOZYME 2
(Homo
sapiens) 		4 / 5 HIS A 311
ILE A 310
SER A  96
ALA A 152
 None
 1.16A 5msdA-3ifcA:
undetectable		 5msdA-3ifcA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 3ifc FRUCTOSE-1,6-BISPHOS
PHATASE ISOZYME 2
(Homo
sapiens) 		5 / 12 ALA A 130
GLY A 122
GLY A 133
ILE A 135
LEU A 318
 None
SO4  A 342 ( 3.0A)
None
None
None
 1.07A 5ul4A-3ifcA:
2.1		 5ul4A-3ifcA:
19.86