SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ife'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		4 / 8 ASP A 143
ASP A 199
TYR A 380
THR A 375
 ZN  A 411 ( 4.6A)
ZN  A 411 (-1.9A)
None
None
 1.48A 1ceaA-3ifeA:
undetectable
1ceaB-3ifeA:
undetectable		 1ceaA-3ifeA:
12.36
1ceaB-3ifeA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		5 / 11 LEU A  48
HIS A 165
LEU A 157
VAL A 170
ILE A 399
 None
 1.41A 1ee2B-3ifeA:
undetectable		 1ee2B-3ifeA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		5 / 11 LEU A 218
ALA A 214
ALA A 216
TYR A 264
LEU A 266
 None
 1.34A 1iiuA-3ifeA:
undetectable		 1iiuA-3ifeA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		4 / 7 HIS A  79
LEU A  77
ASP A 199
PHE A 172
 ZN  A 411 (-3.3A)
None
ZN  A 411 (-1.9A)
None
 1.28A 1ismB-3ifeA:
undetectable		 1ismB-3ifeA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		5 / 12 LEU A 218
ALA A 214
ALA A 216
TYR A 264
LEU A 266
 None
 1.34A 1kt5A-3ifeA:
undetectable		 1kt5A-3ifeA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		4 / 7 MET A 392
PHE A  35
MET A 151
ALA A 153
 None
 1.29A 1linA-3ifeA:
undetectable		 1linA-3ifeA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 3ife PEPTIDASE T
(Bacillus
anthracis) 		4 / 4 HIS A 165
ALA A 403
PHE A 406
GLY A 166
 None
 1.26A 1mj2B-3ifeA:
undetectable		 1mj2B-3ifeA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 3ife PEPTIDASE T
(Bacillus
anthracis) 		4 / 4 HIS A 165
ALA A 403
PHE A 406
GLY A 166
 None
 1.26A 1mj2D-3ifeA:
undetectable		 1mj2D-3ifeA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		4 / 4 HIS A 165
ALA A 403
PHE A 406
GLY A 166
 None
 1.29A 1mjoB-3ifeA:
undetectable		 1mjoB-3ifeA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		4 / 4 HIS A 165
ALA A 403
PHE A 406
GLY A 166
 None
 1.25A 1mjoA-3ifeA:
undetectable		 1mjoA-3ifeA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		4 / 4 HIS A 165
ALA A 403
PHE A 406
GLY A 166
 None
 1.27A 1mjoD-3ifeA:
undetectable		 1mjoD-3ifeA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 3ife PEPTIDASE T
(Bacillus
anthracis) 		5 / 12 ALA A 214
ALA A 216
PHE A 290
TYR A 264
LEU A 266
 None
 1.17A 1qabF-3ifeA:
undetectable		 1qabF-3ifeA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		5 / 10 GLU A 149
GLY A 200
ILE A 150
LEU A 147
ALA A  78
 None
 1.00A 1x7pA-3ifeA:
undetectable
1x7pB-3ifeA:
undetectable		 1x7pA-3ifeA:
20.37
1x7pB-3ifeA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		3 / 3 GLN A  18
LYS A  89
VAL A  91
 None
 0.92A 2jfaB-3ifeA:
undetectable		 2jfaB-3ifeA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		4 / 8 ILE A 400
ILE A 337
ARG A 169
ILE A 163
 None
 0.57A 2nniA-3ifeA:
undetectable		 2nniA-3ifeA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		4 / 5 LEU A 147
LEU A  38
MET A  53
THR A  82
 None
 1.33A 2oaxD-3ifeA:
undetectable		 2oaxD-3ifeA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		4 / 8 TYR A  58
ASP A 199
GLU A 385
GLU A 177
 None
ZN  A 411 (-1.9A)
None
ZN  A 412 (-2.2A)
 1.24A 3dh0A-3ifeA:
undetectable		 3dh0A-3ifeA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		5 / 12 PHE A 185
THR A  62
VAL A 187
LEU A 363
THR A 370
 None
 1.38A 3elzA-3ifeA:
undetectable		 3elzA-3ifeA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		3 / 3 ALA A 171
ARG A 169
LYS A 167
 None
 0.84A 3kp5B-3ifeA:
undetectable		 3kp5B-3ifeA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		5 / 10 GLY A 140
ALA A 141
ASP A 142
GLY A 146
VAL A 389
 None
None
ZN  A 411 ( 2.3A)
None
None
 1.05A 3oxwA-3ifeA:
undetectable		 3oxwA-3ifeA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		4 / 6 GLU A   7
ILE A   6
GLU A 385
VAL A  91
 None
 1.06A 4ejwB-3ifeA:
undetectable		 4ejwB-3ifeA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3ife PEPTIDASE T
(Bacillus
anthracis) 		4 / 5 GLY A 201
GLY A 200
ASN A 372
GLU A 378
 None
 1.29A 4fglC-3ifeA:
2.4		 4fglC-3ifeA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		4 / 7 ASP A 142
GLU A 177
HIS A 381
GLU A 176
 ZN  A 411 ( 2.3A)
ZN  A 412 (-2.2A)
ZN  A 412 (-3.4A)
ZN  A 411 ( 4.0A)
 0.95A 4hvrA-3ifeA:
undetectable		 4hvrA-3ifeA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		4 / 6 TYR A  58
LEU A  39
ASP A 143
ALA A 153
 None
None
ZN  A 411 ( 4.6A)
None
 1.17A 4nkvC-3ifeA:
undetectable		 4nkvC-3ifeA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		3 / 3 PRO A 116
LEU A 122
HIS A  96
 None
None
SO4  A 415 (-3.8A)
 0.72A 4pevA-3ifeA:
undetectable		 4pevA-3ifeA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		5 / 11 HIS A  79
ASP A 142
GLU A 176
GLU A 177
HIS A 381
 ZN  A 411 (-3.3A)
ZN  A 411 ( 2.3A)
ZN  A 411 ( 4.0A)
ZN  A 412 (-2.2A)
ZN  A 412 (-3.4A)
 0.26A 4pqaA-3ifeA:
30.4		 4pqaA-3ifeA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_F_PARF500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		5 / 11 PHE A 190
THR A 173
GLU A 177
ASP A  81
GLY A 181
 None
None
ZN  A 412 (-2.2A)
None
None
 1.48A 4qb9F-3ifeA:
undetectable		 4qb9F-3ifeA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		4 / 7 VAL A  91
ILE A 131
ALA A 141
ILE A 130
 None
 0.87A 4uxqA-3ifeA:
undetectable		 4uxqA-3ifeA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		4 / 8 GLU A 149
GLY A 376
GLY A 377
ASP A 143
 None
None
None
ZN  A 411 ( 4.6A)
 0.67A 5f8yA-3ifeA:
undetectable		 5f8yA-3ifeA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		4 / 8 GLU A 149
GLY A 376
GLY A 377
ASP A 143
 None
None
None
ZN  A 411 ( 4.6A)
 0.66A 5f8yB-3ifeA:
undetectable		 5f8yB-3ifeA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		5 / 10 GLY A 200
GLY A 201
ILE A 150
LEU A 147
ALA A  78
 None
 1.00A 5l0zB-3ifeA:
undetectable		 5l0zB-3ifeA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		4 / 7 ASP A 199
ASP A 359
GLY A 360
ASN A 372
 ZN  A 411 (-1.9A)
None
None
None
 1.01A 5x7pA-3ifeA:
undetectable		 5x7pA-3ifeA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		4 / 4 PHE A  99
LEU A 139
LEU A 114
VAL A 387
 None
 1.36A 5xxiA-3ifeA:
undetectable		 5xxiA-3ifeA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		5 / 12 ILE A 399
VAL A  13
LYS A  14
GLU A  42
VAL A  46
 None
 1.40A 6bzoC-3ifeA:
undetectable		 6bzoC-3ifeA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3ife PEPTIDASE T
(Bacillus
anthracis) 		4 / 7 ILE A 402
VAL A 398
ILE A 373
THR A 375
 None
 1.00A 6cduF-3ifeA:
undetectable
6cduG-3ifeA:
undetectable		 6cduF-3ifeA:
19.78
6cduG-3ifeA:
19.78