SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ifk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 3ifk CALMODULIN
(Rattus
norvegicus) 		8 / 11 PHE A  19
ILE A  27
LEU A  32
MET A  36
LEU A  39
MET A  51
VAL A  55
MET A  71
 None
 0.48A 1dtlA-3ifkA:
11.8		 1dtlA-3ifkA:
57.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 3ifk CALMODULIN
(Rattus
norvegicus) 		4 / 8 MET A  36
GLN A  41
PRO A  43
GLU A  47
 None
 0.77A 1dtlA-3ifkA:
11.8		 1dtlA-3ifkA:
57.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3ifk CALMODULIN
(Rattus
norvegicus) 		7 / 12 PHE A  19
ILE A  27
LEU A  32
MET A  36
ILE A  52
MET A  71
MET A  72
 None
 1.05A 1lxfC-3ifkA:
9.6		 1lxfC-3ifkA:
61.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3ifk CALMODULIN
(Rattus
norvegicus) 		7 / 12 PHE A  19
ILE A  27
LEU A  32
MET A  36
LEU A  39
MET A  51
ILE A  52
 None
 0.83A 1lxfC-3ifkA:
9.6		 1lxfC-3ifkA:
61.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3ifk CALMODULIN
(Rattus
norvegicus) 		7 / 12 PHE A  19
ILE A  27
LEU A  32
MET A  36
MET A  51
ILE A  52
MET A  72
 None
 1.09A 1lxfC-3ifkA:
9.6		 1lxfC-3ifkA:
61.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRK_A_TFPA202_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3ifk CALMODULIN
(Rattus
norvegicus) 		5 / 10 MET A  36
LEU A  39
GLN A  41
GLU A  47
MET A  51
 None
 0.80A 1wrkA-3ifkA:
10.4
1wrkB-3ifkA:
10.2		 1wrkA-3ifkA:
60.67
1wrkB-3ifkA:
60.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3ifk CALMODULIN
(Rattus
norvegicus) 		4 / 8 LEU A   4
PHE A  12
PHE A  68
MET A  72
 None
 0.76A 1wrlC-3ifkA:
10.5
1wrlD-3ifkA:
10.3		 1wrlC-3ifkA:
60.67
1wrlD-3ifkA:
60.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3ifk CALMODULIN
(Rattus
norvegicus) 		4 / 7 PHE A  12
PHE A  19
PHE A  68
MET A  72
 None
 0.89A 1wrlE-3ifkA:
10.3		 1wrlE-3ifkA:
60.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_A_TFPA203_1
(CALMODULIN)		 3ifk CALMODULIN
(Rattus
norvegicus) 		6 / 8 PHE A  19
ILE A  27
LEU A  32
MET A  36
MET A  51
MET A  71
 None
 0.56A 4rjdA-3ifkA:
11.8		 4rjdA-3ifkA:
40.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_B_TFPB203_1
(CALMODULIN)		 3ifk CALMODULIN
(Rattus
norvegicus) 		5 / 7 PHE A  19
LEU A  32
MET A  36
MET A  71
MET A  72
 None
 0.56A 4rjdB-3ifkA:
11.7		 4rjdB-3ifkA:
40.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_B_TFPB203_1
(CALMODULIN)		 3ifk CALMODULIN
(Rattus
norvegicus) 		5 / 7 PHE A  19
LEU A  32
MET A  51
MET A  71
MET A  72
 None
 0.43A 4rjdB-3ifkA:
11.7		 4rjdB-3ifkA:
40.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 3ifk CALMODULIN
(Rattus
norvegicus) 		5 / 10 LEU A  32
MET A  51
VAL A  55
ILE A  63
MET A  72
 None
 0.63A 5v02B-3ifkA:
undetectable
5v02R-3ifkA:
12.4		 5v02B-3ifkA:
20.19
5v02R-3ifkA:
100.00