SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ifs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
anthracis) 		4 / 5 LEU A 330
GLU A 269
ALA A 282
LEU A 278
 None
 1.07A 1eta1-3ifsA:
undetectable		 1eta1-3ifsA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
anthracis) 		4 / 5 LEU A 330
GLU A 269
ALA A 282
LEU A 278
 None
 1.05A 1eta2-3ifsA:
undetectable		 1eta2-3ifsA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
anthracis) 		4 / 6 LEU A 330
GLU A 269
ALA A 282
LEU A 278
 None
 1.11A 1etb1-3ifsA:
undetectable		 1etb1-3ifsA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
anthracis) 		4 / 8 SER A 210
PHE A 116
SER A 223
ILE A 220
 None
 1.02A 1gm7A-3ifsA:
undetectable
1gm7B-3ifsA:
undetectable		 1gm7A-3ifsA:
18.99
1gm7B-3ifsA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
anthracis) 		4 / 8 ARG A  25
GLU A 245
GLN A 253
HIS A  32
 None
 1.20A 1nx9A-3ifsA:
undetectable		 1nx9A-3ifsA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
anthracis) 		4 / 8 ARG A  25
GLU A 245
GLN A 253
HIS A  32
 None
 1.17A 1nx9B-3ifsA:
undetectable		 1nx9B-3ifsA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
anthracis) 		4 / 8 ARG A  25
GLU A 245
GLN A 253
HIS A  32
 None
 1.19A 1nx9C-3ifsA:
undetectable		 1nx9C-3ifsA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
anthracis) 		4 / 8 ARG A  25
GLU A 245
GLN A 253
HIS A  32
 None
 1.18A 1nx9D-3ifsA:
undetectable		 1nx9D-3ifsA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
anthracis) 		4 / 7 TYR A  55
ILE A  63
PRO A 214
GLU A  59
 None
 1.15A 1oniA-3ifsA:
undetectable
1oniB-3ifsA:
undetectable		 1oniA-3ifsA:
15.96
1oniB-3ifsA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
anthracis) 		4 / 6 TYR A  55
ILE A  63
PRO A 214
GLU A  59
 None
 1.15A 1oniB-3ifsA:
undetectable
1oniC-3ifsA:
undetectable		 1oniB-3ifsA:
15.96
1oniC-3ifsA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
anthracis) 		4 / 8 LEU A  46
TRP A  48
ASP A  50
THR A  31
 None
 1.03A 1rmtD-3ifsA:
2.0		 1rmtD-3ifsA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
anthracis) 		4 / 6 LEU A 330
GLU A 269
ALA A 282
LEU A 278
 None
 0.93A 1sn5A-3ifsA:
undetectable		 1sn5A-3ifsA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
anthracis) 		4 / 8 LEU A 330
GLU A 269
ALA A 282
LEU A 278
 None
 0.96A 1sn5C-3ifsA:
undetectable		 1sn5C-3ifsA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
anthracis) 		5 / 12 LEU A 162
ILE A 158
LEU A 115
VAL A 117
LEU A 129
 None
 1.25A 2bxfB-3ifsA:
undetectable		 2bxfB-3ifsA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
anthracis) 		5 / 12 TYR A 280
GLY A 216
VAL A 211
GLY A  88
VAL A  79
 None
 1.20A 3f8wB-3ifsA:
undetectable		 3f8wB-3ifsA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
anthracis) 		4 / 7 PHE A 417
PHE A 209
PHE A 289
SER A 292
 None
 1.35A 3hggA-3ifsA:
undetectable		 3hggA-3ifsA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
anthracis) 		4 / 4 GLY A 233
TYR A 396
GLY A 237
ASP A 240
 None
 1.15A 3kl3A-3ifsA:
undetectable		 3kl3A-3ifsA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
anthracis) 		5 / 12 GLY A 207
PRO A 202
VAL A 205
GLU A  59
TRP A 284
 None
 1.15A 3p2kB-3ifsA:
undetectable		 3p2kB-3ifsA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
anthracis) 		4 / 6 PHE A 417
ASN A  43
ALA A  34
THR A  31
 None
 1.19A 3t3sB-3ifsA:
undetectable		 3t3sB-3ifsA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
anthracis) 		4 / 6 ASN A 102
ARG A  90
TYR A 125
LEU A 129
 None
 1.46A 4f8yA-3ifsA:
3.5
4f8yB-3ifsA:
3.3		 4f8yA-3ifsA:
18.90
4f8yB-3ifsA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
anthracis) 		5 / 12 GLY A 242
PHE A 400
GLY A 237
PRO A 250
TYR A 252
 None
 1.17A 4rtsA-3ifsA:
undetectable		 4rtsA-3ifsA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
anthracis) 		4 / 5 ALA A 366
TYR A 367
GLY A 265
LEU A 382
 None
 0.98A 5eslA-3ifsA:
1.0		 5eslA-3ifsA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
anthracis) 		3 / 3 GLY A 206
GLY A 207
GLN A 419
 None
 0.44A 5imsA-3ifsA:
4.8		 5imsA-3ifsA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
anthracis) 		4 / 5 LEU A 162
TYR A 167
LYS A 166
LEU A 133
 None
 1.27A 5ki6A-3ifsA:
3.9		 5ki6A-3ifsA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE
(Bacillus
anthracis) 		4 / 5 GLU A 327
VAL A 318
HIS A 312
THR A 370
 None
 1.13A 6dyoA-3ifsA:
undetectable		 6dyoA-3ifsA:
11.40