SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ift'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 3ift GLYCINE CLEAVAGE
SYSTEM H PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 ALA A  99
VAL A  92
TRP A  16
 None
 0.93A 1grmA-3iftA:
undetectable		 1grmA-3iftA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 3ift GLYCINE CLEAVAGE
SYSTEM H PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 ALA A  99
VAL A  92
TRP A  16
 None
 0.93A 1grmB-3iftA:
undetectable		 1grmB-3iftA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 3ift GLYCINE CLEAVAGE
SYSTEM H PROTEIN
(Mycobacterium
tuberculosis) 		4 / 5 PRO A  89
VAL A  92
ASN A  93
VAL A  61
 None
 0.85A 1z2bC-3iftA:
undetectable		 1z2bC-3iftA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 3ift GLYCINE CLEAVAGE
SYSTEM H PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 GLU A  80
ASP A 104
TRP A 101
SER A  83
 None
 1.25A 3dzgA-3iftA:
undetectable		 3dzgA-3iftA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 3ift GLYCINE CLEAVAGE
SYSTEM H PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 GLU A  80
ASP A 104
TRP A 101
SER A  83
 None
 1.24A 3dzgB-3iftA:
undetectable		 3dzgB-3iftA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 3ift GLYCINE CLEAVAGE
SYSTEM H PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ASP A  95
GLY A  98
ALA A  99
ASP A  84
ARG A  26
 None
 0.73A 3n3iA-3iftA:
undetectable		 3n3iA-3iftA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 3ift GLYCINE CLEAVAGE
SYSTEM H PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 ASP A  95
GLY A  98
ALA A  99
ASP A  84
 None
 0.73A 3t3cA-3iftA:
undetectable		 3t3cA-3iftA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 3ift GLYCINE CLEAVAGE
SYSTEM H PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 104
VAL A  52
ALA A  51
SER A  79
GLY A  49
 None
 1.27A 4mm4B-3iftA:
undetectable		 4mm4B-3iftA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 3ift GLYCINE CLEAVAGE
SYSTEM H PROTEIN
(Mycobacterium
tuberculosis) 		5 / 9 ASP A 104
VAL A  52
ALA A  51
SER A  79
GLY A  49
 None
 1.23A 4mm5A-3iftA:
undetectable		 4mm5A-3iftA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 3ift GLYCINE CLEAVAGE
SYSTEM H PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 104
VAL A  52
ALA A  51
SER A  79
GLY A  49
 None
 1.24A 4mm6A-3iftA:
undetectable		 4mm6A-3iftA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 3ift GLYCINE CLEAVAGE
SYSTEM H PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 104
VAL A  52
ALA A  51
SER A  79
GLY A  49
 None
 1.18A 4mmdB-3iftA:
undetectable		 4mmdB-3iftA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 3ift GLYCINE CLEAVAGE
SYSTEM H PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 PRO A  89
VAL A  92
ASN A  93
VAL A  61
 None
 0.77A 5bmvC-3iftA:
undetectable		 5bmvC-3iftA:
17.63