SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ifw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 3ifw UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L1
(Homo
sapiens) 		5 / 12 LEU A  17
VAL A  22
GLY A  21
LEU A  13
THR A  92
 None
 1.07A 2egvA-3ifwA:
undetectable		 2egvA-3ifwA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 3ifw UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L1
(Homo
sapiens) 		5 / 12 LEU A 175
ASN A 166
LEU A  49
ALA A  48
LEU A  95
 None
 1.43A 2oaxD-3ifwA:
undetectable		 2oaxD-3ifwA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 3ifw UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L1
(Homo
sapiens) 		5 / 12 LEU A 114
PHE A 133
GLN A  84
LEU A   3
THR A 121
 None
 1.26A 2w3mB-3ifwA:
undetectable		 2w3mB-3ifwA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 3ifw UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L1
(Homo
sapiens) 		5 / 12 ILE A  93
GLY A  94
ILE A 163
ASP A 176
GLY A 177
 None
 0.78A 3bwcA-3ifwA:
undetectable		 3bwcA-3ifwA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 3ifw UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L1
(Homo
sapiens) 		5 / 12 GLU A 109
LEU A 106
GLY A 107
VAL A  99
ALA A 100
 None
 1.24A 4fqsA-3ifwA:
undetectable		 4fqsA-3ifwA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 3ifw UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L1
(Homo
sapiens) 		5 / 12 GLU A 109
LEU A 106
GLY A 107
VAL A  99
ALA A 100
 None
 1.24A 4fqsB-3ifwA:
undetectable		 4fqsB-3ifwA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 3ifw UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L1
(Homo
sapiens) 		5 / 12 LEU A 219
VAL A  99
GLU A 190
SER A 188
GLY A 170
 None
 1.28A 4q15B-3ifwA:
undetectable		 4q15B-3ifwA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 3ifw UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L1
(Homo
sapiens) 		4 / 8 GLU A 174
PHE A 162
GLY A  94
PHE A 204
 None
 1.00A 5flcB-3ifwA:
undetectable		 5flcB-3ifwA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 3ifw UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L1
(Homo
sapiens) 		4 / 8 GLU A 174
PHE A 162
GLY A  94
PHE A 204
 None
 1.00A 5flcF-3ifwA:
undetectable		 5flcF-3ifwA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 3ifw UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L1
(Homo
sapiens) 		5 / 12 VAL A  75
PRO A 182
HIS A 161
PHE A 165
GLY A  94
 None
 1.42A 5xioA-3ifwA:
undetectable		 5xioA-3ifwA:
18.33