SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ig3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 3ig3 PLXNA3 PROTEIN
(Mus
musculus) 		5 / 12 ILE A1796
ASP A1699
LEU A1698
PHE A1695
LEU A1721
 None
 1.19A 1ddrB-3ig3A:
undetectable		 1ddrB-3ig3A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3ig3 PLXNA3 PROTEIN
(Mus
musculus) 		5 / 9 LEU A1440
LEU A1749
THR A1745
ILE A1744
THR A1665
 None
 1.46A 1hzeA-3ig3A:
undetectable
1hzeB-3ig3A:
undetectable		 1hzeA-3ig3A:
9.66
1hzeB-3ig3A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3ig3 PLXNA3 PROTEIN
(Mus
musculus) 		5 / 9 THR A1665
LEU A1440
LEU A1749
THR A1745
ILE A1744
 None
 1.46A 1hzeA-3ig3A:
undetectable
1hzeB-3ig3A:
undetectable		 1hzeA-3ig3A:
9.66
1hzeB-3ig3A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 3ig3 PLXNA3 PROTEIN
(Mus
musculus) 		5 / 10 LEU A1391
LEU A1417
MET A1416
ILE A1348
HIS A1349
 None
 1.34A 1pcgA-3ig3A:
undetectable		 1pcgA-3ig3A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 3ig3 PLXNA3 PROTEIN
(Mus
musculus) 		5 / 12 ILE A1796
ASP A1699
LEU A1698
PHE A1695
LEU A1721
 None
 1.15A 1tdrA-3ig3A:
undetectable		 1tdrA-3ig3A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 3ig3 PLXNA3 PROTEIN
(Mus
musculus) 		4 / 5 LYS A1780
ALA A1779
LEU A1777
SER A1773
 None
 1.00A 1tt6B-3ig3A:
undetectable		 1tt6B-3ig3A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 3ig3 PLXNA3 PROTEIN
(Mus
musculus) 		3 / 3 LEU A1387
LEU A1417
MET A1370
 None
 0.72A 1ya3B-3ig3A:
undetectable		 1ya3B-3ig3A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 3ig3 PLXNA3 PROTEIN
(Mus
musculus) 		5 / 11 LEU A1391
ILE A1392
ASN A1395
LEU A1406
SER A1411
 None
 1.18A 2bxeA-3ig3A:
undetectable		 2bxeA-3ig3A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 3ig3 PLXNA3 PROTEIN
(Mus
musculus) 		5 / 12 LEU A1391
ILE A1392
ASN A1395
LEU A1406
SER A1411
 None
 1.07A 2bxeB-3ig3A:
undetectable		 2bxeB-3ig3A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 3ig3 PLXNA3 PROTEIN
(Mus
musculus) 		4 / 7 GLU A1313
PRO A1733
ARG A1306
GLY A1311
 None
 1.26A 2hs1B-3ig3A:
undetectable		 2hs1B-3ig3A:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 3ig3 PLXNA3 PROTEIN
(Mus
musculus) 		3 / 3 ARG A1306
GLU A1313
GLN A1734
 None
 1.10A 2p16A-3ig3A:
undetectable		 2p16A-3ig3A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 3ig3 PLXNA3 PROTEIN
(Mus
musculus) 		4 / 8 PHE A1343
LEU A1337
PHE A1334
ARG A1839
 None
 0.71A 2vdbA-3ig3A:
undetectable		 2vdbA-3ig3A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 3ig3 PLXNA3 PROTEIN
(Mus
musculus) 		3 / 3 LEU A1861
ARG A1839
ILE A1864
 None
 0.63A 2xn5B-3ig3A:
undetectable		 2xn5B-3ig3A:
6.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 3ig3 PLXNA3 PROTEIN
(Mus
musculus) 		4 / 6 LYS A1780
ALA A1779
LEU A1777
SER A1773
 None
 0.96A 3d2tB-3ig3A:
undetectable		 3d2tB-3ig3A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3ig3 PLXNA3 PROTEIN
(Mus
musculus) 		5 / 9 HIS A1714
LEU A1723
VAL A1789
PHE A1756
VAL A1727
 None
 1.47A 3jwqA-3ig3A:
undetectable		 3jwqA-3ig3A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3ig3 PLXNA3 PROTEIN
(Mus
musculus) 		5 / 9 TYR A1793
HIS A1714
VAL A1789
PHE A1756
VAL A1727
 None
 1.31A 3jwqA-3ig3A:
undetectable		 3jwqA-3ig3A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3ig3 PLXNA3 PROTEIN
(Mus
musculus) 		4 / 5 TYR A1441
ILE A1470
LEU A1469
LYS A1468
 None
 1.07A 3sueC-3ig3A:
undetectable		 3sueC-3ig3A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3ig3 PLXNA3 PROTEIN
(Mus
musculus) 		4 / 8 LEU A1373
VAL A1824
LEU A1344
TYR A1379
 None
 1.05A 3v81A-3ig3A:
undetectable		 3v81A-3ig3A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ig3 PLXNA3 PROTEIN
(Mus
musculus) 		5 / 11 ILE A1796
ASP A1699
LEU A1698
PHE A1695
LEU A1721
 None
 1.22A 4i1nA-3ig3A:
undetectable		 4i1nA-3ig3A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3ig3 PLXNA3 PROTEIN
(Mus
musculus) 		4 / 8 LEU A1373
VAL A1824
LEU A1344
TYR A1379
 None
 0.97A 4puoC-3ig3A:
undetectable		 4puoC-3ig3A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ig3 PLXNA3 PROTEIN
(Mus
musculus) 		5 / 11 ILE A1796
ASP A1699
LEU A1698
PHE A1695
LEU A1721
 None
 1.18A 4qlfA-3ig3A:
undetectable		 4qlfA-3ig3A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 3ig3 PLXNA3 PROTEIN
(Mus
musculus) 		4 / 6 LYS A1780
ALA A1779
LEU A1777
SER A1773
 None
 1.01A 5bojA-3ig3A:
undetectable		 5bojA-3ig3A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3ig3 PLXNA3 PROTEIN
(Mus
musculus) 		4 / 7 LEU A1749
THR A1745
PRO A1733
ILE A1739
 None
 1.01A 5fxtA-3ig3A:
undetectable		 5fxtA-3ig3A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3ig3 PLXNA3 PROTEIN
(Mus
musculus) 		3 / 3 VAL A1560
LEU A1576
MET A1530
 None
 0.85A 5ikrA-3ig3A:
0.7		 5ikrA-3ig3A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 3ig3 PLXNA3 PROTEIN
(Mus
musculus) 		4 / 6 LYS A1780
ALA A1779
LEU A1777
SER A1773
 None
 0.98A 5l4iA-3ig3A:
undetectable		 5l4iA-3ig3A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_1
(MINERALOCORTICOID
RECEPTOR)		 3ig3 PLXNA3 PROTEIN
(Mus
musculus) 		4 / 6 GLN A1667
PHE A1674
CYH A1748
THR A1745
 GOL  A 366 (-4.2A)
None
None
None
 1.20A 5mwyA-3ig3A:
undetectable		 5mwyA-3ig3A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3ig3 PLXNA3 PROTEIN
(Mus
musculus) 		4 / 6 GLU A1466
LYS A1651
LEU A1656
LEU A1659
 None
 1.19A 5yvnA-3ig3A:
undetectable		 5yvnA-3ig3A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 3ig3 PLXNA3 PROTEIN
(Mus
musculus) 		3 / 3 LEU A1377
ASP A1804
ILE A1802
 None
 0.62A 6dh0B-3ig3A:
undetectable		 6dh0B-3ig3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EUQ_A_DXCA502_0
(MULTIDRUG
TRANSPORTER MDFA)		 3ig3 PLXNA3 PROTEIN
(Mus
musculus) 		5 / 11 ASN A1395
LEU A1391
GLN A1386
PRO A1402
LEU A1406
 None
 1.48A 6euqA-3ig3A:
undetectable		 6euqA-3ig3A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 3ig3 PLXNA3 PROTEIN
(Mus
musculus) 		5 / 12 VAL A1365
ALA A1366
GLY A1363
LEU A1344
LEU A1351
 None
 1.12A 6f6iA-3ig3A:
undetectable
6f6iB-3ig3A:
undetectable		 6f6iA-3ig3A:
9.03
6f6iB-3ig3A:
9.11