SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ig4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_A_STRA1_1
(PROGESTERONE
RECEPTOR)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		5 / 12 LEU A 168
ASN A   9
LEU A  13
THR A 173
PHE A   5
 None
 1.46A 1a28A-3ig4A:
undetectable		 1a28A-3ig4A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		4 / 8 PHE A 118
MET A 114
THR A 142
LEU A 128
 None
 0.98A 1ea1A-3ig4A:
undetectable		 1ea1A-3ig4A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_B_MTXB2278_1
(PTERIDINE REDUCTASE
2)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		5 / 11 ARG A 403
ASP A 189
LEU A 215
PHE A 211
THR A 349
 None
 1.38A 1mxfB-3ig4A:
undetectable		 1mxfB-3ig4A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_C_MTXC3278_1
(PTERIDINE REDUCTASE
2)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		5 / 11 ARG A 403
ASP A 189
LEU A 215
PHE A 211
THR A 349
 None
 1.35A 1mxfC-3ig4A:
undetectable		 1mxfC-3ig4A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_D_MTXD4278_1
(PTERIDINE REDUCTASE
2)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		5 / 11 ARG A 403
ASP A 189
LEU A 215
PHE A 211
THR A 349
 None
 1.36A 1mxfD-3ig4A:
undetectable		 1mxfD-3ig4A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		5 / 12 ILE A 117
PHE A 145
ILE A 158
VAL A 156
ILE A  24
 None
 1.32A 1r5lA-3ig4A:
undetectable		 1r5lA-3ig4A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		4 / 8 ILE A  22
PHE A 118
GLU A 121
HIS A 125
 None
 0.95A 2azxA-3ig4A:
undetectable		 2azxA-3ig4A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		5 / 12 PHE A 110
ALA A 144
ALA A 146
LEU A 126
MET A  61
 None
 1.27A 2x2nB-3ig4A:
undetectable		 2x2nB-3ig4A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		5 / 12 PHE A 118
MET A 114
VAL A 123
THR A 142
LEU A 128
 None
 1.01A 2x2nC-3ig4A:
undetectable		 2x2nC-3ig4A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		4 / 7 ILE A 117
PHE A 110
PHE A 145
ILE A  24
 None
 0.84A 2y7wC-3ig4A:
undetectable		 2y7wC-3ig4A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		4 / 7 HIS A 350
ASP A 385
THR A 367
HIS A 239
 SO4  A 430 (-3.6A)
None
MN  A 429 ( 4.6A)
SO4  A 431 ( 3.4A)
 1.38A 3abkA-3ig4A:
undetectable
3abkC-3ig4A:
2.2		 3abkA-3ig4A:
21.63
3abkC-3ig4A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		4 / 7 HIS A 350
ASP A 385
THR A 367
HIS A 239
 SO4  A 430 (-3.6A)
None
MN  A 429 ( 4.6A)
SO4  A 431 ( 3.4A)
 1.43A 3abkN-3ig4A:
undetectable
3abkP-3ig4A:
2.5		 3abkN-3ig4A:
21.63
3abkP-3ig4A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		4 / 6 HIS A 350
ASP A 385
THR A 367
HIS A 239
 SO4  A 430 (-3.6A)
None
MN  A 429 ( 4.6A)
SO4  A 431 ( 3.4A)
 1.39A 3ag1N-3ig4A:
undetectable
3ag1P-3ig4A:
2.5		 3ag1N-3ig4A:
21.63
3ag1P-3ig4A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		4 / 7 HIS A 350
ASP A 385
THR A 367
HIS A 239
 SO4  A 430 (-3.6A)
None
MN  A 429 ( 4.6A)
SO4  A 431 ( 3.4A)
 1.39A 3ag2A-3ig4A:
undetectable
3ag2C-3ig4A:
2.5		 3ag2A-3ig4A:
21.63
3ag2C-3ig4A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		4 / 7 HIS A 350
ASP A 385
THR A 367
HIS A 239
 SO4  A 430 (-3.6A)
None
MN  A 429 ( 4.6A)
SO4  A 431 ( 3.4A)
 1.39A 3ag2N-3ig4A:
undetectable
3ag2P-3ig4A:
2.2		 3ag2N-3ig4A:
21.63
3ag2P-3ig4A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		4 / 7 HIS A 350
ASP A 385
THR A 367
HIS A 239
 SO4  A 430 (-3.6A)
None
MN  A 429 ( 4.6A)
SO4  A 431 ( 3.4A)
 1.41A 3ag3A-3ig4A:
undetectable
3ag3C-3ig4A:
2.2		 3ag3A-3ig4A:
21.63
3ag3C-3ig4A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		4 / 7 HIS A 350
ASP A 385
THR A 367
HIS A 239
 SO4  A 430 (-3.6A)
None
MN  A 429 ( 4.6A)
SO4  A 431 ( 3.4A)
 1.40A 3ag3N-3ig4A:
undetectable
3ag3P-3ig4A:
2.5		 3ag3N-3ig4A:
21.63
3ag3P-3ig4A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		4 / 7 HIS A 350
ASP A 385
THR A 367
HIS A 239
 SO4  A 430 (-3.6A)
None
MN  A 429 ( 4.6A)
SO4  A 431 ( 3.4A)
 1.40A 3ag4A-3ig4A:
undetectable
3ag4C-3ig4A:
2.5		 3ag4A-3ig4A:
21.63
3ag4C-3ig4A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		4 / 6 HIS A 350
ASP A 385
THR A 367
HIS A 239
 SO4  A 430 (-3.6A)
None
MN  A 429 ( 4.6A)
SO4  A 431 ( 3.4A)
 1.39A 3asnA-3ig4A:
undetectable
3asnC-3ig4A:
2.2		 3asnA-3ig4A:
21.63
3asnC-3ig4A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		3 / 3 ARG A 169
ILE A 179
THR A 187
 None
 0.65A 3ia4D-3ig4A:
undetectable		 3ia4D-3ig4A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		5 / 11 ASP A 385
LEU A 345
LEU A 397
ILE A 184
SER A 398
 None
 1.31A 3o94B-3ig4A:
2.2		 3o94B-3ig4A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		5 / 12 LEU A 372
VAL A 289
THR A 296
THR A 297
ILE A 387
 None
 1.14A 3sp9B-3ig4A:
undetectable		 3sp9B-3ig4A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		5 / 12 LEU A 229
ILE A 191
VAL A 194
LEU A 195
ILE A 408
 None
 0.68A 3w67D-3ig4A:
undetectable		 3w67D-3ig4A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C66_A_H4CA1168_0
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		5 / 9 PRO A 273
GLN A 282
LEU A 290
ILE A 408
MET A 412
 None
 1.18A 4c66A-3ig4A:
undetectable		 4c66A-3ig4A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		4 / 5 TYR A 264
LEU A 397
ASP A 174
GLU A 182
 None
 1.08A 4nkvA-3ig4A:
undetectable		 4nkvA-3ig4A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		4 / 5 ILE A 180
LEU A 397
ASP A 174
GLU A 182
 None
 0.99A 4nkxB-3ig4A:
undetectable		 4nkxB-3ig4A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		5 / 11 LEU A 207
LEU A 195
ASN A 416
MET A 412
ILE A 408
 None
 1.18A 4x20D-3ig4A:
undetectable		 4x20D-3ig4A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		4 / 8 LEU A 317
LEU A 293
THR A 271
GLN A 282
 None
 1.08A 5hbsA-3ig4A:
undetectable		 5hbsA-3ig4A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		5 / 12 ALA A 209
ILE A 285
GLY A 371
PHE A 272
THR A 227
 None
 1.35A 5jlcA-3ig4A:
1.8		 5jlcA-3ig4A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		5 / 12 ASP A 385
GLU A 384
ALA A 266
THR A 214
LEU A 257
 None
MN  A 428 ( 2.6A)
None
None
None
 1.33A 5m54B-3ig4A:
undetectable		 5m54B-3ig4A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		5 / 12 LEU A 229
ILE A 191
VAL A 194
LEU A 195
ILE A 408
 None
 0.69A 5mugA-3ig4A:
undetectable		 5mugA-3ig4A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		5 / 12 LEU A 257
PHE A 272
GLY A 380
ILE A 191
GLU A 369
 None
None
None
None
MN  A 429 ( 3.0A)
 1.07A 5veuH-3ig4A:
undetectable		 5veuH-3ig4A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		4 / 6 HIS A 350
ASP A 385
THR A 367
HIS A 239
 SO4  A 430 (-3.6A)
None
MN  A 429 ( 4.6A)
SO4  A 431 ( 3.4A)
 1.33A 5x1bN-3ig4A:
undetectable
5x1bP-3ig4A:
2.2		 5x1bN-3ig4A:
21.63
5x1bP-3ig4A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		4 / 7 HIS A 350
ASP A 385
THR A 367
HIS A 239
 SO4  A 430 (-3.6A)
None
MN  A 429 ( 4.6A)
SO4  A 431 ( 3.4A)
 1.35A 5x1fN-3ig4A:
undetectable
5x1fP-3ig4A:
2.5		 5x1fN-3ig4A:
21.63
5x1fP-3ig4A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CCV_C_RFPC1205_1
(-)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		5 / 12 HIS A 339
LEU A 293
ARG A 403
ILE A 368
HIS A 239
 SO4  A 431 ( 4.3A)
None
None
None
SO4  A 431 ( 3.4A)
 1.14A 6ccvC-3ig4A:
0.6		 6ccvC-3ig4A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ig4 XAA-PRO
AMINOPEPTIDASE
(Bacillus
anthracis) 		4 / 6 HIS A 350
ASP A 385
THR A 367
HIS A 239
 SO4  A 430 (-3.6A)
None
MN  A 429 ( 4.6A)
SO4  A 431 ( 3.4A)
 1.35A 6nknA-3ig4A:
undetectable
6nknC-3ig4A:
2.5		 6nknA-3ig4A:
21.63
6nknC-3ig4A:
17.87