SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3igf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 3igf ALL4481 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 PRO A 344
ALA A 208
LEU A 209
THR A 244
ILE A 300
 None
 1.18A 2jjpA-3igfA:
undetectable		 2jjpA-3igfA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 3igf ALL4481 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 10 ALA A 223
VAL A 268
VAL A 270
ILE A 249
VAL A 248
 None
 1.03A 2nnjA-3igfA:
undetectable		 2nnjA-3igfA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3igf ALL4481 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 8 LEU A 142
LEU A   3
PRO A 299
GLY A 246
 None
 0.95A 2po5B-3igfA:
2.4		 2po5B-3igfA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 3igf ALL4481 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 4 LEU A 226
ASP A 135
VAL A 231
THR A 221
 None
 1.14A 3cyxB-3igfA:
undetectable		 3cyxB-3igfA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 3igf ALL4481 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 GLN A  66
LEU A  38
THR A 133
LEU A  72
ARG A  75
 None
 1.33A 3fsuA-3igfA:
2.4		 3fsuA-3igfA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_E_C2FE995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 3igf ALL4481 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 11 GLN A  66
LEU A  38
THR A 133
LEU A  72
ARG A  75
 None
 1.32A 3fsuE-3igfA:
2.3		 3fsuE-3igfA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 3igf ALL4481 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 9 THR A 138
GLY A 143
GLN A 337
LEU A 142
LEU A 209
 None
 1.42A 3nbqA-3igfA:
2.9		 3nbqA-3igfA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_D_URFD400_1
(URIDINE
PHOSPHORYLASE 1)		 3igf ALL4481 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 9 THR A 138
GLY A 143
GLN A 337
LEU A 142
LEU A 209
 None
 1.46A 3nbqD-3igfA:
2.8		 3nbqD-3igfA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 3igf ALL4481 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 5 GLY A 205
LYS A 206
GLU A 146
PRO A 145
 None
 0.83A 3onnA-3igfA:
2.1		 3onnA-3igfA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3igf ALL4481 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 7 VAL A 309
LEU A 347
LEU A 343
ILE A 352
 None
 1.00A 3u5kB-3igfA:
undetectable		 3u5kB-3igfA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3igf ALL4481 PROTEIN
(Nostoc
sp.
PCC
7120) 		3 / 3 GLN A 250
THR A 222
THR A 221
 None
 0.81A 4fu9A-3igfA:
undetectable		 4fu9A-3igfA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3igf ALL4481 PROTEIN
(Nostoc
sp.
PCC
7120) 		3 / 3 GLN A 250
THR A 222
THR A 221
 None
 0.78A 4fufA-3igfA:
undetectable		 4fufA-3igfA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 3igf ALL4481 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 6 PRO A 314
GLY A 247
ALA A 238
GLN A 295
 None
 0.92A 4g0uA-3igfA:
undetectable		 4g0uA-3igfA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3igf ALL4481 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 VAL A 248
LEU A 243
ALA A 238
LEU A 234
THR A 221
 None
 1.18A 4x1kA-3igfA:
3.4
4x1kB-3igfA:
4.0		 4x1kA-3igfA:
22.03
4x1kB-3igfA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 3igf ALL4481 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 ALA A 238
GLY A 242
GLU A 146
LEU A 142
ASP A 211
 None
 1.36A 5vlmF-3igfA:
1.5		 5vlmF-3igfA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 3igf ALL4481 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 6 ARG A  15
SER A  11
THR A 221
VAL A 231
 None
 0.97A 5ysiA-3igfA:
undetectable		 5ysiA-3igfA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 3igf ALL4481 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 VAL A 321
ASN A 360
ARG A 232
GLU A 262
GLY A 236
 None
 1.31A 6gnfC-3igfA:
undetectable		 6gnfC-3igfA:
22.22