SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3igh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
horikoshii) 		5 / 12 HIS X  83
HIS X  85
ASP X  87
HIS X 355
ASP X 416
 SO4  X   1 (-4.2A)
SO4  X   1 (-4.0A)
None
SO4  X   1 (-4.0A)
SO4  X   1 (-3.0A)
 1.03A 1a4lA-3ighX:
17.7		 1a4lA-3ighX:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
horikoshii) 		5 / 12 HIS X  83
HIS X  85
ASP X  87
HIS X 355
ASP X 416
 SO4  X   1 (-4.2A)
SO4  X   1 (-4.0A)
None
SO4  X   1 (-4.0A)
SO4  X   1 (-3.0A)
 1.00A 1a4lC-3ighX:
17.6		 1a4lC-3ighX:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
horikoshii) 		3 / 3 TRP X 385
VAL X 388
TRP X 386
 None
 0.95A 1c4dC-3ighX:
undetectable
1c4dD-3ighX:
undetectable		 1c4dC-3ighX:
3.32
1c4dD-3ighX:
3.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
horikoshii) 		4 / 5 HIS X  83
HIS X 330
HIS X 355
ASP X 416
 SO4  X   1 (-4.2A)
SO4  X   1 (-3.9A)
SO4  X   1 (-4.0A)
SO4  X   1 (-3.0A)
 0.93A 1e9yB-3ighX:
16.3		 1e9yB-3ighX:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
horikoshii) 		5 / 6 HIS X  83
HIS X  85
HIS X 330
HIS X 355
ASP X 416
 SO4  X   1 (-4.2A)
SO4  X   1 (-4.0A)
SO4  X   1 (-3.9A)
SO4  X   1 (-4.0A)
SO4  X   1 (-3.0A)
 0.94A 1fweC-3ighX:
3.4		 1fweC-3ighX:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
horikoshii) 		4 / 7 GLY X 121
ILE X 147
ALA X 188
ILE X 192
 None
 0.79A 1n49A-3ighX:
undetectable		 1n49A-3ighX:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
horikoshii) 		5 / 10 TYR X 148
ILE X 147
ALA X 155
ILE X 118
ILE X 119
 None
 1.02A 2dm6A-3ighX:
undetectable
2dm6B-3ighX:
undetectable		 2dm6A-3ighX:
21.66
2dm6B-3ighX:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
horikoshii) 		5 / 9 GLY X 412
SER X 414
ILE X 353
THR X 317
VAL X 277
 None
 1.08A 2nnhB-3ighX:
undetectable		 2nnhB-3ighX:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
horikoshii) 		5 / 12 HIS X  83
HIS X  85
ASP X  87
HIS X 355
ASP X 416
 SO4  X   1 (-4.2A)
SO4  X   1 (-4.0A)
None
SO4  X   1 (-4.0A)
SO4  X   1 (-3.0A)
 0.76A 2pgrA-3ighX:
17.1		 2pgrA-3ighX:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8O_A_OINA1314_1
(CHOLINE-BINDING
PROTEIN F)		 3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
horikoshii) 		4 / 5 LYS X 207
ARG X 208
TYR X 204
GLU X  94
 None
 1.33A 2x8oA-3ighX:
undetectable		 2x8oA-3ighX:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
horikoshii) 		5 / 12 GLY X 265
GLY X 324
ALA X 275
ASP X 326
LEU X 259
 None
SO4  X 504 ( 4.3A)
None
None
None
 0.99A 2yqzA-3ighX:
undetectable		 2yqzA-3ighX:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
horikoshii) 		4 / 8 ASP X 326
TYR X 250
VAL X 372
LEU X 374
 None
 1.05A 3jq7C-3ighX:
2.5		 3jq7C-3ighX:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
horikoshii) 		5 / 9 SER X 225
ILE X 329
ALA X 328
ALA X 320
THR X 317
 None
 1.16A 3mdtA-3ighX:
undetectable		 3mdtA-3ighX:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
horikoshii) 		5 / 12 LEU X 374
ILE X 332
ARG X 395
ASP X 334
LEU X 364
 None
 0.70A 3uj6A-3ighX:
undetectable		 3uj6A-3ighX:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
horikoshii) 		4 / 5 HIS X  83
SER X 375
SER X 467
VAL X 466
 SO4  X   1 (-4.2A)
None
None
None
 1.35A 4a99D-3ighX:
undetectable		 4a99D-3ighX:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
horikoshii) 		4 / 5 HIS X 379
LEU X 213
LEU X  93
ASP X 215
 SO4  X   4 (-4.0A)
None
None
None
 1.33A 4aqlA-3ighX:
3.1		 4aqlA-3ighX:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
horikoshii) 		5 / 10 GLY X 412
ALA X 409
GLU X 410
SER X  82
VAL X 376
 None
 1.06A 4da7A-3ighX:
undetectable		 4da7A-3ighX:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
horikoshii) 		4 / 5 HIS X  83
HIS X 330
HIS X 355
ASP X 416
 SO4  X   1 (-4.2A)
SO4  X   1 (-3.9A)
SO4  X   1 (-4.0A)
SO4  X   1 (-3.0A)
 0.96A 4h9mA-3ighX:
17.9		 4h9mA-3ighX:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
horikoshii) 		4 / 8 ILE X 147
ILE X 108
ALA X 140
PRO X 133
 None
 0.79A 4jltA-3ighX:
undetectable		 4jltA-3ighX:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
horikoshii) 		5 / 11 LEU X 285
ALA X 290
LEU X 292
VAL X 359
LEU X 337
 None
 1.13A 4p65C-3ighX:
undetectable
4p65D-3ighX:
undetectable
4p65J-3ighX:
undetectable
4p65L-3ighX:
undetectable		 4p65C-3ighX:
4.64
4p65D-3ighX:
6.05
4p65J-3ighX:
6.05
4p65L-3ighX:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
horikoshii) 		5 / 12 VAL X 376
HIS X 330
GLN X 377
LEU X 285
GLY X 283
 None
SO4  X   1 (-3.9A)
None
None
None
 1.10A 4qckA-3ighX:
undetectable		 4qckA-3ighX:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
horikoshii) 		5 / 6 HIS X  83
HIS X  85
HIS X 330
HIS X 355
ASP X 416
 SO4  X   1 (-4.2A)
SO4  X   1 (-4.0A)
SO4  X   1 (-3.9A)
SO4  X   1 (-4.0A)
SO4  X   1 (-3.0A)
 0.86A 4ubpC-3ighX:
16.1		 4ubpC-3ighX:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
horikoshii) 		5 / 12 ARG X 310
ILE X 329
ASP X 282
ALA X 331
ILE X 353
 None
 1.33A 4uroC-3ighX:
undetectable		 4uroC-3ighX:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
horikoshii) 		3 / 3 ARG X 117
THR X 198
ASP X 201
 None
SO4  X   5 (-4.1A)
None
 0.63A 5g5gA-3ighX:
undetectable
5g5gB-3ighX:
undetectable		 5g5gA-3ighX:
17.63
5g5gB-3ighX:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
horikoshii) 		3 / 3 LYS X 403
ASP X 404
ARG X 434
 None
 1.01A 5jwaA-3ighX:
undetectable
5jwaH-3ighX:
undetectable		 5jwaA-3ighX:
22.38
5jwaH-3ighX:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
horikoshii) 		4 / 8 SER X  82
SER X 222
ALA X 328
ASP X 326
 None
 1.11A 5l5fY-3ighX:
undetectable
5l5fZ-3ighX:
undetectable		 5l5fY-3ighX:
18.81
5l5fZ-3ighX:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE
(Pyrococcus
horikoshii) 		4 / 4 LEU X  70
GLY X  25
SER X  38
SER X  53
 None
 1.25A 5uunA-3ighX:
undetectable		 5uunA-3ighX:
22.84