SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ign'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 3ign DIGUANYLATE CYCLASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 8 ARG A 166
GLY A 234
ARG A 232
THR A 161
 None
 0.82A 2f9wA-3ignA:
undetectable
2f9wB-3ignA:
undetectable		 2f9wA-3ignA:
20.79
2f9wB-3ignA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3ign DIGUANYLATE CYCLASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 7 THR A 216
VAL A 219
THR A 220
ILE A 257
 None
 0.52A 3deuA-3ignA:
1.6		 3deuA-3ignA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 3ign DIGUANYLATE CYCLASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 ASP A 158
GLY A 235
GLY A 209
TYR A 275
ILE A 194
 None
 1.14A 3prsA-3ignA:
undetectable		 3prsA-3ignA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3ign DIGUANYLATE CYCLASE
(Marinobacter
hydrocarbonoclas
ticus) 		3 / 3 TYR A 233
LEU A 154
ARG A 232
 None
 0.77A 3sufB-3ignA:
undetectable		 3sufB-3ignA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 3ign DIGUANYLATE CYCLASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 7 TYR A 275
ILE A 194
PHE A 197
PHE A 238
 None
 1.06A 3tvxB-3ignA:
undetectable		 3tvxB-3ignA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 3ign DIGUANYLATE CYCLASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 11 VAL A 277
ASP A 195
TYR A 275
GLY A 239
PHE A 192
 None
 1.06A 4xp4A-3ignA:
1.0		 4xp4A-3ignA:
13.87