SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3igx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 3igx TRANSALDOLASE
(Francisella
tularensis) 		4 / 7 TYR A 217
PHE A 222
ILE A 143
GLY A 174
 None
 0.65A 11gsA-3igxA:
undetectable		 11gsA-3igxA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 3igx TRANSALDOLASE
(Francisella
tularensis) 		4 / 7 TYR A 217
PHE A 222
ILE A 143
GLY A 174
 None
 0.64A 11gsB-3igxA:
undetectable		 11gsB-3igxA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 3igx TRANSALDOLASE
(Francisella
tularensis) 		5 / 12 ASP A 244
CYH A 243
PRO A 180
SER A 249
ALA A 245
 None
 1.31A 1nw5A-3igxA:
undetectable		 1nw5A-3igxA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 3igx TRANSALDOLASE
(Francisella
tularensis) 		4 / 6 LEU A  81
THR A 111
TYR A 114
TYR A 122
 None
 1.28A 1qvuA-3igxA:
undetectable		 1qvuA-3igxA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3igx TRANSALDOLASE
(Francisella
tularensis) 		5 / 12 TYR A 122
GLY A  85
GLY A  20
THR A  35
ILE A 127
 None
 1.21A 2akeA-3igxA:
undetectable		 2akeA-3igxA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3igx TRANSALDOLASE
(Francisella
tularensis) 		5 / 12 TYR A 122
GLY A  85
GLY A  20
THR A  35
ILE A 127
 None
 1.19A 2azxA-3igxA:
undetectable		 2azxA-3igxA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3igx TRANSALDOLASE
(Francisella
tularensis) 		5 / 12 TYR A 122
GLY A  85
GLY A  20
THR A  35
ILE A 127
 None
 1.20A 2azxB-3igxA:
undetectable		 2azxB-3igxA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3igx TRANSALDOLASE
(Francisella
tularensis) 		5 / 11 TYR A 122
GLY A  85
GLY A  20
THR A  35
ILE A 127
 None
 1.22A 2dr2A-3igxA:
undetectable		 2dr2A-3igxA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 3igx TRANSALDOLASE
(Francisella
tularensis) 		3 / 3 SER A 249
THR A 186
GLN A 236
 None
 0.86A 2fk8A-3igxA:
undetectable		 2fk8A-3igxA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3igx TRANSALDOLASE
(Francisella
tularensis) 		4 / 8 TYR A 217
PHE A 222
ILE A 143
GLY A 174
 None
 0.64A 2gssA-3igxA:
undetectable		 2gssA-3igxA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3igx TRANSALDOLASE
(Francisella
tularensis) 		4 / 8 TYR A 217
PHE A 222
ILE A 143
GLY A 174
 None
 0.63A 2gssB-3igxA:
undetectable		 2gssB-3igxA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 3igx TRANSALDOLASE
(Francisella
tularensis) 		6 / 12 LEU A 158
GLY A 174
ALA A 173
ILE A 280
ALA A 138
ILE A 143
 None
 1.41A 2nmzA-3igxA:
undetectable		 2nmzA-3igxA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 3igx TRANSALDOLASE
(Francisella
tularensis) 		5 / 12 LEU A 252
LEU A 256
THR A 159
VAL A 237
THR A 247
 None
 1.11A 3dcjA-3igxA:
undetectable
3dcjB-3igxA:
undetectable		 3dcjA-3igxA:
24.77
3dcjB-3igxA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3igx TRANSALDOLASE
(Francisella
tularensis) 		4 / 7 TYR A 217
PHE A 222
ILE A 143
GLY A 174
 None
 0.66A 3gssA-3igxA:
undetectable		 3gssA-3igxA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3igx TRANSALDOLASE
(Francisella
tularensis) 		4 / 7 TYR A 217
PHE A 222
ILE A 143
GLY A 174
 None
 0.66A 3gssB-3igxA:
undetectable		 3gssB-3igxA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 3igx TRANSALDOLASE
(Francisella
tularensis) 		4 / 8 TYR A 217
PHE A 222
ILE A 143
GLY A 174
 None
 0.67A 3hjoA-3igxA:
undetectable		 3hjoA-3igxA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 3igx TRANSALDOLASE
(Francisella
tularensis) 		4 / 8 TYR A 217
PHE A 222
ILE A 143
GLY A 174
 None
 0.67A 3n9jA-3igxA:
undetectable		 3n9jA-3igxA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 3igx TRANSALDOLASE
(Francisella
tularensis) 		4 / 8 TYR A 217
PHE A 222
ILE A 143
GLY A 174
 None
 0.67A 3n9jB-3igxA:
undetectable		 3n9jB-3igxA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 3igx TRANSALDOLASE
(Francisella
tularensis) 		4 / 8 ILE A 134
ILE A 154
VAL A 100
ILE A 112
 None
 0.85A 3p4wC-3igxA:
undetectable		 3p4wC-3igxA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 3igx TRANSALDOLASE
(Francisella
tularensis) 		5 / 12 ASP A 101
PHE A 306
THR A 310
PHE A 181
ALA A 138
 None
 1.29A 3ua1A-3igxA:
undetectable		 3ua1A-3igxA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 3igx TRANSALDOLASE
(Francisella
tularensis) 		5 / 11 SER A 179
VAL A 175
LEU A 158
THR A 159
ALA A 146
 None
 1.03A 4e0fA-3igxA:
undetectable		 4e0fA-3igxA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 3igx TRANSALDOLASE
(Francisella
tularensis) 		4 / 4 ILE A 311
ASN A 315
ILE A 317
VAL A  73
 None
 1.30A 4uy87-3igxA:
undetectable		 4uy87-3igxA:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3igx TRANSALDOLASE
(Francisella
tularensis) 		4 / 4 LEU A  89
ILE A  92
GLY A  85
ILE A  25
 None
 0.88A 5dzk3-3igxA:
undetectable
5dzkm-3igxA:
undetectable		 5dzk3-3igxA:
0.62
5dzkm-3igxA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3igx TRANSALDOLASE
(Francisella
tularensis) 		4 / 5 ILE A  92
GLY A  85
ILE A  25
LEU A  89
 None
 0.85A 5dzkB-3igxA:
2.2
5dzkI-3igxA:
undetectable
5dzkW-3igxA:
undetectable		 5dzkB-3igxA:
21.61
5dzkI-3igxA:
21.17
5dzkW-3igxA:
0.62