SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3igz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		5 / 11 THR B 497
GLY B 428
THR B 436
VAL B  36
VAL B 440
 None
 1.24A 1akdA-3igzB:
undetectable		 1akdA-3igzB:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		4 / 5 ASP B 425
HIS B 429
HIS B 467
HIS B 496
 CO  B 562 (-2.1A)
CO  B 562 (-3.2A)
CO  B 563 ( 3.1A)
CO  B 562 (-3.3A)
 0.40A 1ei6A-3igzB:
17.9		 1ei6A-3igzB:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		5 / 8 ASP B  23
ASP B 425
HIS B 429
HIS B 467
HIS B 496
 CO  B 563 ( 2.2A)
CO  B 562 (-2.1A)
CO  B 562 (-3.2A)
CO  B 563 ( 3.1A)
CO  B 562 (-3.3A)
 0.52A 1ei6C-3igzB:
17.7		 1ei6C-3igzB:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		4 / 8 HIS B 467
SER B  75
HIS B 360
ARG B 282
 CO  B 563 ( 3.1A)
CO  B 563 (-1.8A)
3PG  B 564 ( 4.2A)
3PG  B 564 ( 2.8A)
 1.28A 1eqbA-3igzB:
undetectable
1eqbB-3igzB:
undetectable		 1eqbA-3igzB:
21.80
1eqbB-3igzB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		4 / 8 HIS B 467
SER B  75
HIS B 360
ARG B 282
 CO  B 563 ( 3.1A)
CO  B 563 (-1.8A)
3PG  B 564 ( 4.2A)
3PG  B 564 ( 2.8A)
 1.27A 1eqbA-3igzB:
undetectable
1eqbB-3igzB:
undetectable		 1eqbA-3igzB:
21.80
1eqbB-3igzB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		4 / 8 HIS B 467
SER B  75
HIS B 360
ARG B 282
 CO  B 563 ( 3.1A)
CO  B 563 (-1.8A)
3PG  B 564 ( 4.2A)
3PG  B 564 ( 2.8A)
 1.27A 1eqbC-3igzB:
undetectable
1eqbD-3igzB:
undetectable		 1eqbC-3igzB:
21.80
1eqbD-3igzB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		4 / 8 HIS B 467
SER B  75
HIS B 360
ARG B 282
 CO  B 563 ( 3.1A)
CO  B 563 (-1.8A)
3PG  B 564 ( 4.2A)
3PG  B 564 ( 2.8A)
 1.27A 1eqbC-3igzB:
undetectable
1eqbD-3igzB:
undetectable		 1eqbC-3igzB:
21.80
1eqbD-3igzB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		4 / 4 ILE B 145
LEU B 180
VAL B 159
ILE B 157
 None
 0.87A 1fm6D-3igzB:
undetectable		 1fm6D-3igzB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		5 / 12 SER B 470
LEU B 447
VAL B 463
PHE B 504
ALA B 465
 None
 1.20A 1q23D-3igzB:
undetectable
1q23E-3igzB:
undetectable		 1q23D-3igzB:
15.44
1q23E-3igzB:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		5 / 12 SER B 131
LEU B 129
ASP B 284
HIS B 360
VAL B 135
 None
None
2PG  B 565 ( 4.5A)
3PG  B 564 ( 4.2A)
2PG  B 565 (-4.6A)
 1.23A 1uobA-3igzB:
undetectable		 1uobA-3igzB:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		5 / 11 THR B 497
GLY B 428
THR B 436
VAL B  36
VAL B 440
 None
 1.28A 2a1nA-3igzB:
undetectable		 2a1nA-3igzB:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		4 / 7 ASP B  31
ALA B 474
ASP B  32
TYR B  33
 None
 1.21A 2e5dA-3igzB:
undetectable
2e5dB-3igzB:
undetectable		 2e5dA-3igzB:
21.45
2e5dB-3igzB:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		4 / 7 ASP B  32
TYR B  33
ASP B  31
ALA B 474
 None
 1.22A 2e5dA-3igzB:
undetectable
2e5dB-3igzB:
undetectable		 2e5dA-3igzB:
21.45
2e5dB-3igzB:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		4 / 7 GLU B 218
PRO B 255
ARG B 219
GLY B 220
 None
 1.26A 2hs1B-3igzB:
undetectable		 2hs1B-3igzB:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		5 / 12 ILE B 419
GLY B 412
ASN B 415
LEU B 536
VAL B 454
 None
 1.44A 2nyrB-3igzB:
undetectable		 2nyrB-3igzB:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		5 / 12 HIS B 429
GLY B  73
HIS B 496
ASP B 425
ASP B  23
 CO  B 562 (-3.2A)
None
CO  B 562 (-3.3A)
CO  B 562 (-2.1A)
CO  B 563 ( 2.2A)
 1.09A 2pgrA-3igzB:
undetectable		 2pgrA-3igzB:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		4 / 7 TYR B 163
THR B 177
VAL B 159
VAL B 259
 None
 1.00A 2qbnA-3igzB:
undetectable		 2qbnA-3igzB:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		4 / 7 HIS B 467
SER B  75
ASP B 425
ARG B 209
 CO  B 563 ( 3.1A)
CO  B 563 (-1.8A)
CO  B 562 (-2.1A)
3PG  B 564 ( 3.2A)
 1.47A 2rk8B-3igzB:
undetectable		 2rk8B-3igzB:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		4 / 8 ASP B 318
SER B 370
TYR B 363
TYR B 210
 None
 1.38A 2v0gA-3igzB:
undetectable		 2v0gA-3igzB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		4 / 8 HIS B 467
SER B  75
HIS B 360
ARG B 282
 CO  B 563 ( 3.1A)
CO  B 563 (-1.8A)
3PG  B 564 ( 4.2A)
3PG  B 564 ( 2.8A)
 1.33A 2vmyA-3igzB:
undetectable
2vmyB-3igzB:
undetectable		 2vmyA-3igzB:
22.01
2vmyB-3igzB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		5 / 12 ILE B 419
LEU B 450
VAL B 443
GLU B 445
THR B  41
 None
None
None
None
NA  B 601 (-2.8A)
 1.08A 2vn0A-3igzB:
undetectable		 2vn0A-3igzB:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		5 / 12 ALA B 465
GLY B 468
GLY B  73
LEU B 447
PRO B 502
 None
 1.01A 2y7hB-3igzB:
2.1		 2y7hB-3igzB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		5 / 12 ALA B 465
GLY B 468
GLY B  73
LEU B 447
PRO B 502
 None
 1.01A 2y7hC-3igzB:
2.3		 2y7hC-3igzB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		5 / 9 ALA B  39
VAL B 440
GLY B 439
LEU B 433
ALA B  35
 NA  B 601 (-4.4A)
None
None
None
None
 0.98A 2z0yA-3igzB:
4.0		 2z0yA-3igzB:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		4 / 5 PRO B 266
THR B 206
VAL B 205
GLY B 220
 None
 1.07A 3elzA-3igzB:
undetectable		 3elzA-3igzB:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		4 / 8 ASP B 471
SER B 470
ASP B 425
ASP B 167
 None
None
CO  B 562 (-2.1A)
2PG  B 565 ( 2.4A)
 1.07A 3havA-3igzB:
undetectable		 3havA-3igzB:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		5 / 10 THR B 497
GLY B 428
THR B 436
VAL B  36
VAL B 440
 None
 1.31A 3lxiA-3igzB:
undetectable		 3lxiA-3igzB:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		5 / 12 ILE B 258
VAL B 259
LEU B 267
ILE B 146
TYR B 143
 None
 0.84A 3mb5A-3igzB:
4.8		 3mb5A-3igzB:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		4 / 7 ALA B  81
VAL B  57
VAL B 528
LEU B  82
 None
 0.86A 3o14A-3igzB:
undetectable		 3o14A-3igzB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		4 / 8 ARG B 166
LEU B  25
ASP B 466
SER B  75
 3PG  B 564 ( 3.9A)
None
CO  B 563 (-2.4A)
CO  B 563 (-1.8A)
 1.00A 3qj7A-3igzB:
undetectable
3qj7D-3igzB:
undetectable		 3qj7A-3igzB:
20.00
3qj7D-3igzB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		4 / 7 VAL B 501
GLY B 468
VAL B  77
VAL B  64
 None
 0.75A 3ufnB-3igzB:
undetectable		 3ufnB-3igzB:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		4 / 5 GLY B 109
TYR B 311
TYR B 112
GLU B 294
 None
 1.40A 4ae1B-3igzB:
undetectable		 4ae1B-3igzB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_1
(NEURAMINIDASE)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		5 / 12 ARG B 166
ASP B 425
SER B 353
GLU B 354
ARG B 285
 3PG  B 564 ( 3.9A)
CO  B 562 (-2.1A)
None
None
3PG  B 564 ( 3.8A)
 1.49A 4b7qC-3igzB:
undetectable		 4b7qC-3igzB:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		5 / 9 THR B 464
LEU B  82
GLY B  78
VAL B  57
VAL B 501
 None
 1.49A 4c9kB-3igzB:
undetectable		 4c9kB-3igzB:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		5 / 12 HIS B 496
HIS B 429
GLY B 428
ASP B  23
GLY B  24
 CO  B 562 (-3.3A)
CO  B 562 (-3.2A)
None
CO  B 563 ( 2.2A)
None
 1.21A 4lxzA-3igzB:
3.3		 4lxzA-3igzB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		5 / 12 HIS B 496
HIS B 429
GLY B 428
ASP B  23
GLY B  24
 CO  B 562 (-3.3A)
CO  B 562 (-3.2A)
None
CO  B 563 ( 2.2A)
None
 1.20A 4lxzC-3igzB:
3.1		 4lxzC-3igzB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		4 / 8 VAL B 417
LEU B  18
TYR B 461
VAL B 443
 None
 0.97A 4ma7A-3igzB:
undetectable		 4ma7A-3igzB:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		3 / 3 ALA B 195
GLN B 224
GLY B 220
 None
 0.55A 4odoC-3igzB:
undetectable		 4odoC-3igzB:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		3 / 3 ASP B  23
ASP B 466
ASN B  80
 CO  B 563 ( 2.2A)
CO  B 563 (-2.4A)
None
 0.80A 4q5mA-3igzB:
undetectable		 4q5mA-3igzB:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		5 / 12 GLY B 199
GLY B 220
SER B 198
ALA B 235
ALA B 161
 None
 0.80A 4uciA-3igzB:
3.9		 4uciA-3igzB:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		5 / 12 GLY B 199
GLY B 220
SER B 198
ALA B 235
ALA B 161
 None
 0.80A 4uciB-3igzB:
3.6		 4uciB-3igzB:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		5 / 12 GLY B 199
GLY B 220
SER B 198
ALA B 235
ALA B 161
 None
 0.80A 4uckA-3igzB:
3.9		 4uckA-3igzB:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		4 / 5 GLY B 133
ASP B 167
ARG B 202
MET B 315
 None
2PG  B 565 ( 2.4A)
3PG  B 564 ( 2.8A)
None
 1.41A 5gwkA-3igzB:
2.1		 5gwkA-3igzB:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		3 / 3 ASP B 170
ASN B 391
GLN B 389
 None
 0.70A 5k7uA-3igzB:
undetectable		 5k7uA-3igzB:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		5 / 9 VAL B  20
LEU B 450
ASP B 455
VAL B 417
ILE B 419
 None
 1.17A 5om2A-3igzB:
undetectable
5om2B-3igzB:
undetectable		 5om2A-3igzB:
7.49
5om2B-3igzB:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Leishmania
mexicana) 		3 / 3 HIS B  79
HIS B 360
ARG B 282
 None
3PG  B 564 ( 4.2A)
3PG  B 564 ( 2.8A)
 1.06A 6b58A-3igzB:
undetectable		 6b58A-3igzB:
21.67