SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ih5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 3ih5 ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA-SUBUNIT
(Bacteroides
thetaiotaomicron) 		4 / 8 MET A  94
LEU A 111
VAL A 107
VAL A  39
 None
 1.00A 2bdmA-3ih5A:
undetectable		 2bdmA-3ih5A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3ih5 ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA-SUBUNIT
(Bacteroides
thetaiotaomicron) 		5 / 8 VAL A 107
ILE A  79
TYR A 193
PHE A  63
PHE A  84
 None
None
MLA  A 216 (-3.7A)
None
None
 1.33A 2weyB-3ih5A:
undetectable		 2weyB-3ih5A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ih5 ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA-SUBUNIT
(Bacteroides
thetaiotaomicron) 		4 / 7 GLU A 169
VAL A  17
ARG A 101
VAL A 167
 None
None
FMT  A 218 ( 4.1A)
None
 1.32A 3jx5A-3ih5A:
undetectable
3jx5B-3ih5A:
undetectable		 3jx5A-3ih5A:
19.58
3jx5B-3ih5A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ih5 ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA-SUBUNIT
(Bacteroides
thetaiotaomicron) 		4 / 7 GLU A 169
VAL A  17
ARG A 101
VAL A 167
 None
None
FMT  A 218 ( 4.1A)
None
 1.29A 3jx6A-3ih5A:
undetectable
3jx6B-3ih5A:
undetectable		 3jx6A-3ih5A:
20.65
3jx6B-3ih5A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ih5 ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA-SUBUNIT
(Bacteroides
thetaiotaomicron) 		4 / 7 GLU A 169
VAL A  17
ARG A 101
VAL A 167
 None
None
FMT  A 218 ( 4.1A)
None
 1.33A 5adeA-3ih5A:
undetectable
5adeB-3ih5A:
undetectable		 5adeA-3ih5A:
19.58
5adeB-3ih5A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3ih5 ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA-SUBUNIT
(Bacteroides
thetaiotaomicron) 		4 / 7 SER A 108
ASP A 118
ARG A 168
GLY A  95
 None
None
FMT  A 218 (-3.4A)
None
 1.04A 5btfA-3ih5A:
undetectable
5btfC-3ih5A:
undetectable
5btfD-3ih5A:
2.0		 5btfA-3ih5A:
17.78
5btfC-3ih5A:
17.78
5btfD-3ih5A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3ih5 ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA-SUBUNIT
(Bacteroides
thetaiotaomicron) 		4 / 6 SER A 108
ASP A 118
ARG A 168
GLY A  95
 None
None
FMT  A 218 (-3.4A)
None
 0.99A 5cdqA-3ih5A:
undetectable
5cdqC-3ih5A:
undetectable
5cdqD-3ih5A:
2.2		 5cdqA-3ih5A:
19.32
5cdqC-3ih5A:
19.32
5cdqD-3ih5A:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 3ih5 ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA-SUBUNIT
(Bacteroides
thetaiotaomicron) 		4 / 6 GLY A  95
THR A  97
SER A  18
VAL A  17
 None
 1.12A 5ewuA-3ih5A:
undetectable		 5ewuA-3ih5A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ih5 ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA-SUBUNIT
(Bacteroides
thetaiotaomicron) 		4 / 7 GLU A 169
VAL A  17
ARG A 101
VAL A 167
 None
None
FMT  A 218 ( 4.1A)
None
 1.34A 5g0pA-3ih5A:
undetectable
5g0pB-3ih5A:
undetectable		 5g0pA-3ih5A:
19.58
5g0pB-3ih5A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3ih5 ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA-SUBUNIT
(Bacteroides
thetaiotaomicron) 		4 / 7 ILE A  99
GLY A 100
LEU A  36
PHE A   4
 None
 0.84A 5hieB-3ih5A:
undetectable		 5hieB-3ih5A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_A_ASCA1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3ih5 ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA-SUBUNIT
(Bacteroides
thetaiotaomicron) 		4 / 6 HIS A 188
VAL A  39
TYR A   6
HIS A  76
 None
 1.41A 5kkzA-3ih5A:
undetectable
5kkzG-3ih5A:
undetectable		 5kkzA-3ih5A:
19.04
5kkzG-3ih5A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 3ih5 ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA-SUBUNIT
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 115
GLY A  95
ALA A 165
GLU A 169
THR A  97
 None
 1.26A 5x6yA-3ih5A:
2.2		 5x6yA-3ih5A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3ih5 ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA-SUBUNIT
(Bacteroides
thetaiotaomicron) 		3 / 3 LEU A 139
GLN A 163
LYS A 134
 None
 0.84A 6exiB-3ih5A:
3.4		 6exiB-3ih5A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3ih5 ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA-SUBUNIT
(Bacteroides
thetaiotaomicron) 		3 / 3 LEU A 139
GLN A 163
LYS A 134
 None
 0.81A 6exiA-3ih5A:
3.3		 6exiA-3ih5A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3ih5 ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA-SUBUNIT
(Bacteroides
thetaiotaomicron) 		5 / 10 SER A 113
GLY A 114
ALA A 165
GLY A 104
LEU A  53
 None
 1.19A 6hqbA-3ih5A:
undetectable
6hqbJ-3ih5A:
undetectable		 6hqbA-3ih5A:
15.64
6hqbJ-3ih5A:
11.52