SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ihg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 3ihg RDME
(Streptomyces
purpurascens) 		4 / 8 VAL A 532
ASP A 330
TRP A 333
LEU A 503
 None
 1.02A 1pk2A-3ihgA:
undetectable		 1pk2A-3ihgA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 3ihg RDME
(Streptomyces
purpurascens) 		5 / 11 GLY A  16
GLY A 328
LEU A 305
ALA A 178
ALA A 309
 FAD  A 536 (-3.9A)
None
None
None
None
 1.00A 1x7pA-3ihgA:
undetectable
1x7pB-3ihgA:
undetectable		 1x7pA-3ihgA:
20.88
1x7pB-3ihgA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 3ihg RDME
(Streptomyces
purpurascens) 		5 / 11 LEU A 393
LEU A 392
VAL A 362
ALA A 323
LEU A  56
 None
 1.11A 2q72A-3ihgA:
1.2		 2q72A-3ihgA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3ihg RDME
(Streptomyces
purpurascens) 		5 / 12 ALA A 358
THR A  53
ALA A 326
ASP A 327
TYR A 388
 None
 1.45A 2qm9A-3ihgA:
undetectable		 2qm9A-3ihgA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_B_GEOB1207_1
(DEOXYNUCLEOSIDE
KINASE)		 3ihg RDME
(Streptomyces
purpurascens) 		5 / 12 ILE A 509
GLU A  55
VAL A 441
ARG A  52
PHE A 395
 None
 1.27A 2vppB-3ihgA:
undetectable		 2vppB-3ihgA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3ihg RDME
(Streptomyces
purpurascens) 		4 / 8 THR A 237
ARG A  45
ILE A 206
ASP A 238
 None
None
None
SO4  A 546 ( 4.3A)
 1.11A 2xytE-3ihgA:
undetectable		 2xytE-3ihgA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 3ihg RDME
(Streptomyces
purpurascens) 		4 / 5 TYR A 223
GLU A 216
ARG A  82
ASP A 210
 None
 1.25A 2yqzA-3ihgA:
2.3		 2yqzA-3ihgA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 3ihg RDME
(Streptomyces
purpurascens) 		4 / 5 TYR A 223
GLU A 216
ARG A  82
ASP A 210
 None
 1.25A 2yqzB-3ihgA:
2.4		 2yqzB-3ihgA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3ihg RDME
(Streptomyces
purpurascens) 		5 / 12 ALA A 452
VAL A 504
TRP A 512
GLY A 453
ILE A 496
 None
 1.37A 3a65A-3ihgA:
undetectable		 3a65A-3ihgA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ihg RDME
(Streptomyces
purpurascens) 		5 / 12 VAL A 303
ALA A 306
ALA A 178
LEU A 331
VAL A 157
 None
 0.96A 3fc6C-3ihgA:
undetectable		 3fc6C-3ihgA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3ihg RDME
(Streptomyces
purpurascens) 		5 / 6 THR A 110
LEU A 393
GLY A 394
ALA A 112
PRO A  51
 None
 1.41A 3huoA-3ihgA:
undetectable		 3huoA-3ihgA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 3ihg RDME
(Streptomyces
purpurascens) 		3 / 3 GLU A 365
GLY A 317
THR A 316
 None
VAK  A 537 (-3.0A)
VAK  A 537 (-4.2A)
 0.57A 3iazA-3ihgA:
undetectable		 3iazA-3ihgA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3ihg RDME
(Streptomyces
purpurascens) 		4 / 8 THR A 524
LEU A 529
ALA A 463
ALA A 462
 None
 0.98A 3ns1L-3ihgA:
1.1		 3ns1L-3ihgA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 3ihg RDME
(Streptomyces
purpurascens) 		4 / 8 MET A 102
SER A  96
ILE A  81
ARG A  82
 VAK  A 537 ( 4.2A)
None
None
None
 1.02A 3sfeB-3ihgA:
undetectable
3sfeC-3ihgA:
undetectable		 3sfeB-3ihgA:
17.62
3sfeC-3ihgA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 3ihg RDME
(Streptomyces
purpurascens) 		5 / 12 GLY A 387
LEU A 393
GLY A 394
ASN A 414
ALA A 368
 None
 1.00A 3vywC-3ihgA:
undetectable		 3vywC-3ihgA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 3ihg RDME
(Streptomyces
purpurascens) 		5 / 12 SER A  19
LEU A 175
VAL A  10
GLY A 177
ALA A 178
 None
 1.16A 4coxA-3ihgA:
undetectable		 4coxA-3ihgA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 3ihg RDME
(Streptomyces
purpurascens) 		5 / 12 SER A  19
LEU A 175
VAL A  10
GLY A 177
ALA A 178
 None
 1.16A 4coxB-3ihgA:
undetectable		 4coxB-3ihgA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 3ihg RDME
(Streptomyces
purpurascens) 		5 / 12 SER A  19
LEU A 175
VAL A  10
GLY A 177
ALA A 178
 None
 1.16A 4coxD-3ihgA:
undetectable		 4coxD-3ihgA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 3ihg RDME
(Streptomyces
purpurascens) 		5 / 12 ARG A 425
ARG A 505
SER A 439
VAL A 431
HIS A 428
 None
 1.16A 4ffwA-3ihgA:
2.1		 4ffwA-3ihgA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ihg RDME
(Streptomyces
purpurascens) 		4 / 6 GLU A 354
ARG A 355
ASP A 507
ARG A  52
 None
 1.22A 4kcnA-3ihgA:
undetectable		 4kcnA-3ihgA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ihg RDME
(Streptomyces
purpurascens) 		4 / 6 GLU A 354
ARG A 355
ASP A 507
ARG A  52
 None
 1.23A 4kcnB-3ihgA:
undetectable		 4kcnB-3ihgA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 3ihg RDME
(Streptomyces
purpurascens) 		4 / 5 LEU A 225
ASP A 274
ARG A  88
ILE A 214
 None
 1.18A 4mwrA-3ihgA:
undetectable		 4mwrA-3ihgA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3ihg RDME
(Streptomyces
purpurascens) 		4 / 8 PHE A 234
THR A 219
GLU A  97
ASP A  78
 None
 0.93A 4qb9D-3ihgA:
undetectable		 4qb9D-3ihgA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 3ihg RDME
(Streptomyces
purpurascens) 		5 / 12 PHE A  23
THR A  53
ARG A  58
LEU A  15
LEU A 126
 None
None
None
FAD  A 536 (-4.6A)
None
 1.05A 4qynB-3ihgA:
undetectable		 4qynB-3ihgA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 3ihg RDME
(Streptomyces
purpurascens) 		4 / 6 LEU A  56
LEU A 392
THR A 110
VAL A 441
 None
 1.06A 4udaA-3ihgA:
undetectable		 4udaA-3ihgA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 3ihg RDME
(Streptomyces
purpurascens) 		3 / 4 ARG A  36
GLY A 140
GLU A  35
 FAD  A 536 (-4.1A)
None
FAD  A 536 (-2.9A)
 0.65A 4z2dB-3ihgA:
undetectable
4z2dC-3ihgA:
undetectable		 4z2dB-3ihgA:
23.58
4z2dC-3ihgA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3ihg RDME
(Streptomyces
purpurascens) 		5 / 12 GLY A  14
PHE A  79
ILE A  81
GLY A 235
THR A 244
 FAD  A 536 (-3.3A)
VAK  A 537 (-4.7A)
None
None
None
 1.10A 4zdyA-3ihgA:
undetectable		 4zdyA-3ihgA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3ihg RDME
(Streptomyces
purpurascens) 		5 / 12 GLY A  14
PHE A  79
ILE A  81
GLY A 235
THR A 244
 FAD  A 536 (-3.3A)
VAK  A 537 (-4.7A)
None
None
None
 1.12A 4ze2A-3ihgA:
undetectable		 4ze2A-3ihgA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3ihg RDME
(Streptomyces
purpurascens) 		5 / 12 GLY A  14
PHE A  79
ILE A  81
GLY A 221
GLY A 235
 FAD  A 536 (-3.3A)
VAK  A 537 (-4.7A)
None
None
None
 0.79A 5eqbA-3ihgA:
undetectable		 5eqbA-3ihgA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3ihg RDME
(Streptomyces
purpurascens) 		5 / 12 GLY A  16
PHE A  79
ILE A  81
GLY A 221
GLY A 235
 FAD  A 536 (-3.9A)
VAK  A 537 (-4.7A)
None
None
None
 0.93A 5eqbA-3ihgA:
undetectable		 5eqbA-3ihgA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3ihg RDME
(Streptomyces
purpurascens) 		5 / 12 GLY A  14
PHE A  79
ILE A  81
GLY A 235
THR A 244
 FAD  A 536 (-3.3A)
VAK  A 537 (-4.7A)
None
None
None
 1.13A 5eskA-3ihgA:
undetectable		 5eskA-3ihgA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3ihg RDME
(Streptomyces
purpurascens) 		5 / 12 GLY A  14
PHE A  79
ILE A  81
GLY A 235
THR A 244
 FAD  A 536 (-3.3A)
VAK  A 537 (-4.7A)
None
None
None
 1.09A 5eslA-3ihgA:
undetectable		 5eslA-3ihgA:
22.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3ihg RDME
(Streptomyces
purpurascens) 		5 / 12 GLY A  48
GLY A 204
THR A 316
GLY A 317
GLY A 318
 VAK  A 537 ( 4.6A)
None
VAK  A 537 (-4.2A)
VAK  A 537 (-3.0A)
VAK  A 537 (-3.2A)
 0.88A 5koxA-3ihgA:
34.2		 5koxA-3ihgA:
33.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 3ihg RDME
(Streptomyces
purpurascens) 		4 / 7 GLY A  12
GLU A  35
ARG A 138
ASP A 179
 FAD  A 536 (-3.1A)
FAD  A 536 (-2.9A)
SO4  A 544 (-3.2A)
None
 1.08A 5n5dB-3ihgA:
3.1		 5n5dB-3ihgA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3ihg RDME
(Streptomyces
purpurascens) 		4 / 8 HIS A 201
LEU A 199
THR A 198
ALA A 291
 None
None
SO4  A 540 (-3.9A)
None
 0.78A 5tt3H-3ihgA:
undetectable		 5tt3H-3ihgA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 3ihg RDME
(Streptomyces
purpurascens) 		5 / 12 LEU A 331
GLY A 328
PHE A 329
THR A 350
VAL A  31
 None
 1.03A 5x66F-3ihgA:
undetectable		 5x66F-3ihgA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3ihg RDME
(Streptomyces
purpurascens) 		5 / 12 VAL A 362
THR A 313
LEU A 392
GLY A 318
VAL A 386
 None
None
None
VAK  A 537 (-3.2A)
None
 1.14A 6a94B-3ihgA:
undetectable		 6a94B-3ihgA:
20.78