SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ihj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 3ihj ALANINE
AMINOTRANSFERASE 2
(Homo
sapiens) 		4 / 7 VAL A 507
LEU A 504
THR A 420
LEU A 423
 None
 0.94A 1jgsA-3ihjA:
undetectable		 1jgsA-3ihjA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 3ihj ALANINE
AMINOTRANSFERASE 2
(Homo
sapiens) 		3 / 3 ARG A 374
GLY A 190
ASP A 189
 None
 0.53A 1kf6A-3ihjA:
undetectable
1kf6B-3ihjA:
undetectable		 1kf6A-3ihjA:
21.85
1kf6B-3ihjA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 3ihj ALANINE
AMINOTRANSFERASE 2
(Homo
sapiens) 		5 / 12 PHE A 336
ILE A 211
ILE A 194
VAL A 209
ILE A 197
 None
 1.21A 1r5lA-3ihjA:
2.2		 1r5lA-3ihjA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 3ihj ALANINE
AMINOTRANSFERASE 2
(Homo
sapiens) 		5 / 12 PRO A 377
ILE A 387
GLY A 351
ILE A 159
SER A 340
 None
None
None
None
PLP  A   1 ( 4.1A)
 0.91A 1sg9A-3ihjA:
3.7		 1sg9A-3ihjA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 3ihj ALANINE
AMINOTRANSFERASE 2
(Homo
sapiens) 		5 / 12 PRO A 377
ILE A 387
GLY A 351
ILE A 159
SER A 340
 None
None
None
None
PLP  A   1 ( 4.1A)
 0.90A 1sg9B-3ihjA:
4.1		 1sg9B-3ihjA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 3ihj ALANINE
AMINOTRANSFERASE 2
(Homo
sapiens) 		4 / 8 HIS A 337
SER A 315
PHE A 313
ASP A 304
 None
 1.19A 2p02A-3ihjA:
undetectable		 2p02A-3ihjA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 3ihj ALANINE
AMINOTRANSFERASE 2
(Homo
sapiens) 		5 / 12 PRO A 378
PRO A 377
THR A 185
GLY A 351
THR A 339
 None
 1.21A 2uvnA-3ihjA:
undetectable		 2uvnA-3ihjA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_B_ECNB1406_1
(CYTOCHROME P450 130)		 3ihj ALANINE
AMINOTRANSFERASE 2
(Homo
sapiens) 		5 / 11 PRO A 378
PRO A 377
THR A 185
GLY A 351
THR A 339
 None
 1.15A 2uvnB-3ihjA:
undetectable		 2uvnB-3ihjA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 3ihj ALANINE
AMINOTRANSFERASE 2
(Homo
sapiens) 		4 / 8 THR A 273
PRO A 272
GLU A 237
PRO A 214
 None
 1.12A 2v41G-3ihjA:
undetectable
2v41H-3ihjA:
undetectable		 2v41G-3ihjA:
20.37
2v41H-3ihjA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 3ihj ALANINE
AMINOTRANSFERASE 2
(Homo
sapiens) 		4 / 8 HIS A 337
VAL A 388
GLY A 186
ALA A 187
 None
None
PLP  A   1 (-3.2A)
PLP  A   1 (-3.6A)
 0.95A 2xh9A-3ihjA:
undetectable		 2xh9A-3ihjA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 3ihj ALANINE
AMINOTRANSFERASE 2
(Homo
sapiens) 		5 / 12 ALA A  93
ILE A 476
MET A 495
THR A 506
LEU A 419
 None
 1.30A 3cl9A-3ihjA:
2.5		 3cl9A-3ihjA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 3ihj ALANINE
AMINOTRANSFERASE 2
(Homo
sapiens) 		5 / 10 LYS A  85
PRO A  86
LEU A  79
ILE A  75
GLY A 475
 None
 1.23A 3ijxB-3ihjA:
undetectable
3ijxD-3ihjA:
undetectable		 3ijxB-3ihjA:
18.90
3ijxD-3ihjA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 3ihj ALANINE
AMINOTRANSFERASE 2
(Homo
sapiens) 		5 / 10 LYS A  85
PRO A  86
LEU A  79
ILE A  75
GLY A 475
 None
 1.32A 3iluB-3ihjA:
undetectable
3iluE-3ihjA:
undetectable		 3iluB-3ihjA:
18.90
3iluE-3ihjA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 3ihj ALANINE
AMINOTRANSFERASE 2
(Homo
sapiens) 		5 / 11 ILE A  75
GLY A 475
LYS A  85
PRO A  86
LEU A  79
 None
 1.32A 3iluB-3ihjA:
undetectable
3iluE-3ihjA:
undetectable		 3iluB-3ihjA:
18.90
3iluE-3ihjA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ihj ALANINE
AMINOTRANSFERASE 2
(Homo
sapiens) 		3 / 3 ARG A 279
LYS A 318
ARG A 312
 None
PO4  A   2 (-3.5A)
PO4  A   2 (-3.3A)
 0.75A 3w1wA-3ihjA:
3.0
3w1wB-3ihjA:
3.5		 3w1wA-3ihjA:
24.81
3w1wB-3ihjA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ihj ALANINE
AMINOTRANSFERASE 2
(Homo
sapiens) 		3 / 3 ARG A 312
ARG A 279
LYS A 318
 PO4  A   2 (-3.3A)
None
PO4  A   2 (-3.5A)
 0.81A 3w1wA-3ihjA:
3.0
3w1wB-3ihjA:
3.5		 3w1wA-3ihjA:
24.81
3w1wB-3ihjA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 3ihj ALANINE
AMINOTRANSFERASE 2
(Homo
sapiens) 		5 / 12 THR A 168
VAL A 174
GLN A 303
GLU A 300
ILE A 181
 None
 1.35A 4s0vA-3ihjA:
2.3		 4s0vA-3ihjA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3ihj ALANINE
AMINOTRANSFERASE 2
(Homo
sapiens) 		4 / 8 HIS A 337
SER A 315
PHE A 313
ASP A 304
 None
 1.17A 5a1iA-3ihjA:
undetectable		 5a1iA-3ihjA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 3ihj ALANINE
AMINOTRANSFERASE 2
(Homo
sapiens) 		3 / 3 MET A 385
HIS A 337
GLY A 345
 None
 0.73A 5gwzB-3ihjA:
undetectable		 5gwzB-3ihjA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 3ihj ALANINE
AMINOTRANSFERASE 2
(Homo
sapiens) 		3 / 3 PRO A 178
ARG A 160
GLU A 161
 None
 0.97A 5j6hA-3ihjA:
undetectable		 5j6hA-3ihjA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 3ihj ALANINE
AMINOTRANSFERASE 2
(Homo
sapiens) 		5 / 9 ALA A 187
SER A 338
GLY A 352
SER A 188
GLY A 190
 PLP  A   1 (-3.6A)
PLP  A   1 (-2.6A)
None
PLP  A   1 (-2.7A)
None
 1.19A 6bklE-3ihjA:
undetectable
6bklF-3ihjA:
undetectable
6bklG-3ihjA:
undetectable
6bklH-3ihjA:
undetectable		 6bklE-3ihjA:
5.40
6bklF-3ihjA:
5.40
6bklG-3ihjA:
5.40
6bklH-3ihjA:
5.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3ihj ALANINE
AMINOTRANSFERASE 2
(Homo
sapiens) 		4 / 8 HIS A 337
SER A 315
PHE A 313
ASP A 304
 None
 1.19A 6fboA-3ihjA:
undetectable		 6fboA-3ihjA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3ihj ALANINE
AMINOTRANSFERASE 2
(Homo
sapiens) 		4 / 8 HIS A 337
SER A 315
PHE A 313
ASP A 304
 None
 1.20A 6fcdA-3ihjA:
undetectable		 6fcdA-3ihjA:
11.45