SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ihl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 3ihl CTP SYNTHASE 2
(Homo
sapiens) 		6 / 11 VAL A 121
ILE A  88
GLY A  91
ILE A  43
PRO A 158
ILE A 117
 None
 1.47A 1c6yA-3ihlA:
undetectable		 1c6yA-3ihlA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 3ihl CTP SYNTHASE 2
(Homo
sapiens) 		5 / 12 ARG A 217
GLY A   9
ASP A 153
THR A 150
ASN A 199
 ADP  A 300 (-3.5A)
None
None
None
None
 1.33A 3a25A-3ihlA:
2.2		 3a25A-3ihlA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 3ihl CTP SYNTHASE 2
(Homo
sapiens) 		6 / 12 GLY A  15
ILE A  18
ILE A  19
SER A 181
VAL A 180
ILE A 178
 ADP  A 300 (-3.4A)
ADP  A 300 (-4.3A)
None
None
None
None
 0.80A 4ax8A-3ihlA:
undetectable		 4ax8A-3ihlA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 3ihl CTP SYNTHASE 2
(Homo
sapiens) 		6 / 12 GLY A  15
ILE A  18
ILE A  19
SER A 181
VAL A 180
ILE A 178
 ADP  A 300 (-3.4A)
ADP  A 300 (-4.3A)
None
None
None
None
 0.76A 4azvA-3ihlA:
undetectable		 4azvA-3ihlA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3ihl CTP SYNTHASE 2
(Homo
sapiens) 		4 / 8 GLY A  17
GLY A  15
VAL A   6
VAL A 253
 ADP  A 300 (-3.4A)
ADP  A 300 (-3.4A)
None
None
 0.79A 4c5nC-3ihlA:
4.0		 4c5nC-3ihlA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3ihl CTP SYNTHASE 2
(Homo
sapiens) 		5 / 10 VAL A 144
VAL A   6
ILE A 178
LEU A 272
LEU A 270
 None
 1.28A 4jtqA-3ihlA:
2.3		 4jtqA-3ihlA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3ihl CTP SYNTHASE 2
(Homo
sapiens) 		5 / 12 THR A   7
GLY A 149
GLY A 148
LEU A 147
LEU A 207
 None
PO4  A 301 (-3.0A)
PO4  A 301 (-3.8A)
None
None
 0.99A 5c0oF-3ihlA:
undetectable		 5c0oF-3ihlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3ihl CTP SYNTHASE 2
(Homo
sapiens) 		4 / 8 ILE A  14
GLY A   9
PHE A 163
PHE A 159
 ADP  A 300 (-4.9A)
None
None
None
 0.86A 5hieD-3ihlA:
undetectable		 5hieD-3ihlA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 3ihl CTP SYNTHASE 2
(Homo
sapiens) 		5 / 9 ILE A  18
ALA A  20
ILE A  19
ILE A  26
LEU A 257
 ADP  A 300 (-4.3A)
None
None
None
None
 1.03A 5mvmA-3ihlA:
undetectable
5mvmE-3ihlA:
undetectable		 5mvmA-3ihlA:
13.28
5mvmE-3ihlA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 3ihl CTP SYNTHASE 2
(Homo
sapiens) 		5 / 10 ILE A  26
LEU A 257
ILE A  18
ALA A  20
ILE A  19
 None
None
ADP  A 300 (-4.3A)
None
None
 1.02A 5mvmD-3ihlA:
undetectable
5mvmE-3ihlA:
undetectable		 5mvmD-3ihlA:
13.28
5mvmE-3ihlA:
13.28