SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ihp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens) 		5 / 11 LEU A 602
PHE A 562
ILE A 571
LEU A 569
THR A 559
 None
 1.27A 1jomA-3ihpA:
undetectable		 1jomA-3ihpA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens) 		4 / 8 ILE A 599
LEU A 602
PHE A 562
LEU A 489
 None
 0.92A 1v55N-3ihpA:
undetectable
1v55W-3ihpA:
undetectable		 1v55N-3ihpA:
18.99
1v55W-3ihpA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens) 		3 / 3 GLN A 572
ILE A 573
TYR A 826
 None
 0.69A 1vifA-3ihpA:
undetectable		 1vifA-3ihpA:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens) 		5 / 12 HIS A 236
LEU A 210
GLN A 185
PHE A 279
ILE A 192
 None
 1.48A 1xosA-3ihpA:
undetectable		 1xosA-3ihpA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens) 		4 / 6 ALA A 816
TYR A 809
ILE A 808
LEU A 320
 None
 0.92A 1xvaA-3ihpA:
undetectable
1xvaB-3ihpA:
undetectable		 1xvaA-3ihpA:
16.02
1xvaB-3ihpA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens) 		4 / 5 TYR A 778
TYR A 830
ILE A 571
GLY A 776
 None
 1.23A 2du8G-3ihpA:
undetectable		 2du8G-3ihpA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens) 		4 / 8 ILE A 599
LEU A 602
PHE A 562
LEU A 489
 None
 0.93A 2eijN-3ihpA:
undetectable
2eijW-3ihpA:
undetectable		 2eijN-3ihpA:
18.99
2eijW-3ihpA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens) 		4 / 8 ILE A 599
LEU A 602
PHE A 562
LEU A 489
 None
 0.95A 2eikN-3ihpA:
undetectable
2eikW-3ihpA:
undetectable		 2eikN-3ihpA:
18.99
2eikW-3ihpA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens) 		4 / 8 ILE A 599
LEU A 602
PHE A 562
LEU A 489
 None
 0.93A 2eilN-3ihpA:
undetectable
2eilW-3ihpA:
undetectable		 2eilN-3ihpA:
18.99
2eilW-3ihpA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens) 		4 / 5 PHE A 829
PHE A 345
PHE A 440
ILE A 412
 None
 1.38A 2v0mD-3ihpA:
undetectable		 2v0mD-3ihpA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens) 		4 / 8 ILE A 599
LEU A 602
PHE A 562
LEU A 489
 None
 0.95A 3asnN-3ihpA:
undetectable
3asnW-3ihpA:
undetectable		 3asnN-3ihpA:
18.99
3asnW-3ihpA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens) 		5 / 12 ARG A 352
ASP A 567
VAL A 570
PRO A 566
LEU A 344
 None
 1.12A 3ku1G-3ihpA:
undetectable		 3ku1G-3ihpA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens) 		5 / 11 ALA A 731
ILE A 707
LEU A 721
LEU A 718
ALA A 717
 None
 1.22A 3kw2A-3ihpA:
undetectable		 3kw2A-3ihpA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens) 		5 / 11 ALA A 731
ILE A 707
LEU A 721
LEU A 718
ALA A 717
 None
 1.25A 3kw2B-3ihpA:
undetectable		 3kw2B-3ihpA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens) 		5 / 11 TYR A 568
LEU A 533
ILE A 571
ILE A 599
TYR A 778
 None
 1.23A 4a7aA-3ihpA:
undetectable		 4a7aA-3ihpA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens) 		4 / 7 PHE A 461
TYR A 568
VAL A 570
ILE A 827
 None
 1.11A 4a97E-3ihpA:
undetectable		 4a97E-3ihpA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens) 		4 / 8 PHE A 461
TYR A 568
VAL A 570
ILE A 827
 None
 1.05A 4a97D-3ihpA:
undetectable		 4a97D-3ihpA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens) 		4 / 8 PHE A 461
TYR A 568
VAL A 570
ILE A 827
 None
 1.10A 4a97G-3ihpA:
undetectable		 4a97G-3ihpA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens) 		4 / 7 PHE A 461
TYR A 568
VAL A 570
ILE A 827
 None
 1.09A 4a97H-3ihpA:
undetectable		 4a97H-3ihpA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens) 		4 / 8 PHE A 461
TYR A 568
VAL A 570
ILE A 827
 None
 1.09A 4a97I-3ihpA:
undetectable		 4a97I-3ihpA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens) 		5 / 10 GLY A 137
ASP A 134
ALA A 132
GLY A 135
VAL A 147
 None
 1.28A 4c5nD-3ihpA:
undetectable		 4c5nD-3ihpA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens) 		5 / 12 ASP A 262
ALA A 233
TYR A 237
VAL A 234
THR A 213
 None
 1.27A 4mm4B-3ihpA:
undetectable		 4mm4B-3ihpA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens) 		4 / 4 ASN A 211
SER A 260
ALA A 245
VAL A 246
 None
 0.83A 4x1kC-3ihpA:
undetectable		 4x1kC-3ihpA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens) 		4 / 4 ASN A 211
SER A 260
ALA A 245
VAL A 246
 None
 0.84A 5nm5A-3ihpA:
undetectable		 5nm5A-3ihpA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens) 		5 / 10 MET A 446
LEU A 443
VAL A 377
LEU A 380
ASP A 372
 None
 1.24A 5tixB-3ihpA:
undetectable		 5tixB-3ihpA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_B_SALB503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens) 		4 / 7 THR A 367
HIS A  61
GLN A  67
THR A  15
 None
 1.44A 5u6mB-3ihpA:
undetectable		 5u6mB-3ihpA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens) 		4 / 8 ILE A 599
LEU A 602
PHE A 562
LEU A 489
 None
 0.92A 5xdxN-3ihpA:
undetectable
5xdxW-3ihpA:
undetectable		 5xdxN-3ihpA:
18.99
5xdxW-3ihpA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEE_B_RXMB601_0
(SCAFFOLD PROTEIN D13)		 3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens) 		5 / 9 PHE A 461
PHE A 440
PHE A 345
VAL A 570
PHE A 428
 None
 1.08A 6beeA-3ihpA:
0.0
6beeB-3ihpA:
0.0
6beeC-3ihpA:
0.0		 6beeA-3ihpA:
21.11
6beeB-3ihpA:
21.11
6beeC-3ihpA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens) 		3 / 3 TYR A 828
PRO A 594
LEU A 597
 None
 0.86A 6beoA-3ihpA:
undetectable		 6beoA-3ihpA:
1.21