SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iht'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 3iht S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE
(Ruegeria
pomeroyi) 		5 / 12 GLU A  45
GLY A  47
GLY A  49
ASP A  90
ILE A  91
 SAM  A 200 ( 4.8A)
SAM  A 200 (-3.3A)
SAM  A 200 (-3.2A)
SAM  A 200 (-3.2A)
SAM  A 200 (-3.9A)
 0.82A 1qaoA-3ihtA:
8.0		 1qaoA-3ihtA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3iht S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE
(Ruegeria
pomeroyi) 		5 / 9 VAL A 109
LEU A  46
PHE A 150
MET A 148
LEU A  95
 None
 1.36A 1wrkA-3ihtA:
undetectable
1wrkB-3ihtA:
undetectable		 1wrkA-3ihtA:
16.76
1wrkB-3ihtA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 3iht S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE
(Ruegeria
pomeroyi) 		3 / 3 GLY A  47
GLU A  70
ASP A 112
 SAM  A 200 (-3.3A)
SAM  A 200 (-2.7A)
SAM  A 200 (-3.7A)
 0.58A 2b25B-3ihtA:
9.8		 2b25B-3ihtA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3iht S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE
(Ruegeria
pomeroyi) 		4 / 7 GLY A  47
GLY A  49
THR A  53
GLU A  70
 SAM  A 200 (-3.3A)
SAM  A 200 (-3.2A)
SAM  A 200 (-3.4A)
SAM  A 200 (-2.7A)
 0.60A 3fpjB-3ihtA:
9.0		 3fpjB-3ihtA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3iht S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE
(Ruegeria
pomeroyi) 		5 / 12 GLY A  47
THR A  53
GLU A  70
ASP A  90
ASP A 112
 SAM  A 200 (-3.3A)
SAM  A 200 (-3.4A)
SAM  A 200 (-2.7A)
SAM  A 200 (-3.2A)
SAM  A 200 (-3.7A)
 0.79A 3id6C-3ihtA:
11.4		 3id6C-3ihtA:
22.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 3iht S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE
(Ruegeria
pomeroyi) 		11 / 12 GLY A  47
GLY A  49
ASN A  50
GLY A  51
ARG A  52
THR A  53
ASP A  90
ILE A  91
ASP A 112
LEU A 113
PHE A 124
 SAM  A 200 (-3.3A)
SAM  A 200 (-3.2A)
None
SAM  A 200 (-3.7A)
None
SAM  A 200 (-3.4A)
SAM  A 200 (-3.2A)
SAM  A 200 (-3.9A)
SAM  A 200 (-3.7A)
SAM  A 200 ( 4.5A)
SAM  A 200 (-4.6A)
 0.07A 3ihtA-3ihtA:
35.8		 3ihtA-3ihtA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3iht S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE
(Ruegeria
pomeroyi) 		4 / 4 GLY A  47
GLU A  70
ASP A  90
ASP A 112
 SAM  A 200 (-3.3A)
SAM  A 200 (-2.7A)
SAM  A 200 (-3.2A)
SAM  A 200 (-3.7A)
 0.56A 3mb5A-3ihtA:
11.2		 3mb5A-3ihtA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3iht S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE
(Ruegeria
pomeroyi) 		4 / 4 LEU A  48
GLY A  49
GLY A  51
THR A  53
 None
SAM  A 200 (-3.2A)
SAM  A 200 (-3.7A)
SAM  A 200 (-3.4A)
 0.66A 3si7A-3ihtA:
undetectable		 3si7A-3ihtA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3iht S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE
(Ruegeria
pomeroyi) 		4 / 5 LEU A  48
GLY A  49
GLY A  51
THR A  53
 None
SAM  A 200 (-3.2A)
SAM  A 200 (-3.7A)
SAM  A 200 (-3.4A)
 0.65A 3si7C-3ihtA:
undetectable
3si7D-3ihtA:
undetectable		 3si7C-3ihtA:
22.10
3si7D-3ihtA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 3iht S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE
(Ruegeria
pomeroyi) 		4 / 6 GLY A  49
GLU A  70
ASP A  90
ASP A 112
 SAM  A 200 (-3.2A)
SAM  A 200 (-2.7A)
SAM  A 200 (-3.2A)
SAM  A 200 (-3.7A)
 0.61A 3vywC-3ihtA:
11.5		 3vywC-3ihtA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 3iht S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE
(Ruegeria
pomeroyi) 		5 / 12 GLN A  35
LEU A 141
VAL A 143
ILE A 169
CYH A 167
 None
 1.01A 4k36B-3ihtA:
undetectable		 4k36B-3ihtA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3iht S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE
(Ruegeria
pomeroyi) 		4 / 6 GLY A  47
GLU A  45
ASP A  90
ASP A 112
 SAM  A 200 (-3.3A)
SAM  A 200 ( 4.8A)
SAM  A 200 (-3.2A)
SAM  A 200 (-3.7A)
 1.01A 4uckB-3ihtA:
7.2		 4uckB-3ihtA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3iht S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE
(Ruegeria
pomeroyi) 		5 / 12 GLY A  49
GLY A  51
GLU A  70
ASP A 112
LEU A 113
 SAM  A 200 (-3.2A)
SAM  A 200 (-3.7A)
SAM  A 200 (-2.7A)
SAM  A 200 (-3.7A)
SAM  A 200 ( 4.5A)
 0.89A 5c0oF-3ihtA:
9.8		 5c0oF-3ihtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 3iht S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE
(Ruegeria
pomeroyi) 		4 / 7 GLY A  47
GLY A  49
GLU A  70
ASP A  90
 SAM  A 200 (-3.3A)
SAM  A 200 (-3.2A)
SAM  A 200 (-2.7A)
SAM  A 200 (-3.2A)
 0.65A 5ergB-3ihtA:
9.6		 5ergB-3ihtA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3iht S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE
(Ruegeria
pomeroyi) 		4 / 6 ILE A  33
VAL A  43
VAL A  61
SER A 107
 None
 0.99A 5jwaH-3ihtA:
3.1		 5jwaH-3ihtA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3iht S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE
(Ruegeria
pomeroyi) 		4 / 7 GLY A  47
GLU A  70
ALA A  72
ASP A  90
 SAM  A 200 (-3.3A)
SAM  A 200 (-2.7A)
None
SAM  A 200 (-3.2A)
 0.74A 5mvsA-3ihtA:
9.3		 5mvsA-3ihtA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3iht S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE
(Ruegeria
pomeroyi) 		4 / 8 GLY A  47
GLU A  70
ALA A  72
ASP A  90
 SAM  A 200 (-3.3A)
SAM  A 200 (-2.7A)
None
SAM  A 200 (-3.2A)
 0.73A 5mvsB-3ihtA:
9.3		 5mvsB-3ihtA:
19.64