SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ihv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 4 LEU A  69
PRO A  88
LEU A  66
ARG A 301
 None
 1.21A 1hrkB-3ihvA:
undetectable		 1hrkB-3ihvA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A 544
PHE A 157
VAL A  99
 EDO  A  18 ( 3.6A)
None
None
 0.74A 1kijB-3ihvA:
undetectable		 1kijB-3ihvA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 ALA A 220
GLY A 222
ARG A 208
ALA A 195
PRO A 200
 None
 1.02A 1mjqC-3ihvA:
undetectable
1mjqD-3ihvA:
undetectable		 1mjqC-3ihvA:
12.73
1mjqD-3ihvA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 10 ARG A 208
ALA A 195
PRO A 200
ALA A 220
GLY A 222
 None
 1.00A 1mjqG-3ihvA:
undetectable
1mjqH-3ihvA:
undetectable		 1mjqG-3ihvA:
12.73
1mjqH-3ihvA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 ALA A 220
GLY A 222
ARG A 208
ALA A 195
PRO A 200
 None
 1.02A 1mjqI-3ihvA:
undetectable
1mjqJ-3ihvA:
undetectable		 1mjqI-3ihvA:
12.73
1mjqJ-3ihvA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 11 LEU A  46
TYR A  50
ILE A 120
LEU A 199
LEU A 137
 None
EDO  A 559 ( 4.3A)
None
None
None
 1.24A 1mrqA-3ihvA:
undetectable		 1mrqA-3ihvA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 ASN A 384
GLN A 382
ASN A 523
TRP A 515
 None
 1.13A 1p6kA-3ihvA:
undetectable		 1p6kA-3ihvA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 ASN A 384
GLN A 382
ASN A 523
TRP A 515
 None
 1.10A 1p6kB-3ihvA:
undetectable		 1p6kB-3ihvA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 ASN A 384
GLN A 382
ASN A 523
TRP A 515
 None
 1.08A 1rs6A-3ihvA:
undetectable		 1rs6A-3ihvA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 ASN A 384
GLN A 382
ASN A 523
TRP A 515
 None
 1.04A 1rs6B-3ihvA:
2.7		 1rs6B-3ihvA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 ASN A 384
GLN A 382
ASN A 523
TRP A 515
 None
 1.09A 1rs7B-3ihvA:
undetectable		 1rs7B-3ihvA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 TYR A 213
TYR A 415
TRP A 276
LEU A 261
 None
 1.41A 1uw6A-3ihvA:
undetectable
1uw6B-3ihvA:
undetectable		 1uw6A-3ihvA:
19.53
1uw6B-3ihvA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 TYR A 213
TYR A 415
TRP A 276
LEU A 261
 None
 1.39A 1uw6D-3ihvA:
undetectable
1uw6E-3ihvA:
undetectable		 1uw6D-3ihvA:
19.53
1uw6E-3ihvA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 TYR A 213
TYR A 415
TRP A 276
LEU A 261
 None
 1.36A 1uw6G-3ihvA:
undetectable
1uw6H-3ihvA:
undetectable		 1uw6G-3ihvA:
19.53
1uw6H-3ihvA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 TYR A 213
TYR A 415
TRP A 276
LEU A 261
 None
 1.35A 1uw6P-3ihvA:
undetectable
1uw6Q-3ihvA:
undetectable		 1uw6P-3ihvA:
19.53
1uw6Q-3ihvA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 TRP A 276
LEU A 261
TYR A 213
TYR A 415
 None
 1.44A 1uw6P-3ihvA:
undetectable
1uw6T-3ihvA:
undetectable		 1uw6P-3ihvA:
19.53
1uw6T-3ihvA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 ASN A 384
GLN A 382
ASN A 523
TRP A 515
 None
 1.12A 1zzqA-3ihvA:
undetectable		 1zzqA-3ihvA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 ASN A 384
GLN A 382
ASN A 523
TRP A 515
 None
 1.07A 1zzqB-3ihvA:
undetectable		 1zzqB-3ihvA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 ASN A 384
GLN A 382
ASN A 523
TRP A 515
 None
 1.14A 1zzuA-3ihvA:
undetectable		 1zzuA-3ihvA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 ASN A 384
GLN A 382
ASN A 523
TRP A 515
 None
 1.09A 1zzuB-3ihvA:
2.7		 1zzuB-3ihvA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 10 LEU A 260
ALA A 420
GLU A 480
SER A 346
LEU A 345
 None
 1.15A 2bxeA-3ihvA:
undetectable		 2bxeA-3ihvA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 4 LEU A  69
PRO A  88
LEU A  66
ARG A 301
 None
 1.27A 2hrcA-3ihvA:
undetectable		 2hrcA-3ihvA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 4 LEU A  69
PRO A  88
LEU A  66
ARG A 301
 None
 1.22A 2pnjB-3ihvA:
undetectable		 2pnjB-3ihvA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A 282
GLU A 141
LEU A 145
TYR A 415
 None
 1.26A 2w8yA-3ihvA:
undetectable		 2w8yA-3ihvA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 GLU A 280
LEU A 267
ARG A 342
ALA A 420
 None
 0.99A 3ax9B-3ihvA:
undetectable		 3ax9B-3ihvA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 ALA A 420
GLU A 280
GLN A 266
ILE A 341
LEU A 345
 None
None
EDO  A 558 (-3.1A)
None
None
 1.46A 3ia4A-3ihvA:
undetectable		 3ia4A-3ihvA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 454
ARG A 449
ALA A 420
TRP A 334
ARG A 418
 None
 1.31A 3jzjA-3ihvA:
undetectable		 3jzjA-3ihvA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 ARG A  51
LEU A 145
ILE A 120
PHE A 116
 None
 1.14A 3ln1D-3ihvA:
undetectable		 3ln1D-3ihvA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 ASN A 159
VAL A 160
GLY A 158
LEU A 162
GLU A 182
 None
 1.35A 3medA-3ihvA:
undetectable
3medB-3ihvA:
undetectable		 3medA-3ihvA:
22.22
3medB-3ihvA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 ASN A 384
GLN A 382
ASN A 523
TRP A 515
 None
 1.14A 3n62A-3ihvA:
undetectable		 3n62A-3ihvA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 ASN A 384
GLN A 382
ASN A 523
TRP A 515
 None
 1.06A 3n62B-3ihvA:
undetectable		 3n62B-3ihvA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 ASN A 384
GLN A 382
ASN A 523
TRP A 515
 None
 1.04A 3n66B-3ihvA:
undetectable		 3n66B-3ihvA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		6 / 12 LEU A 417
GLY A 218
ALA A 220
ALA A 144
LEU A 192
LEU A 252
 None
 1.35A 3p5nA-3ihvA:
undetectable		 3p5nA-3ihvA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		6 / 12 LEU A 417
GLY A 218
ALA A 220
ALA A 144
LEU A 192
LEU A 252
 None
 1.35A 3p5nB-3ihvA:
1.7		 3p5nB-3ihvA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 4 PRO A  88
LEU A  66
ILE A  65
ARG A 301
 None
 1.33A 3w1wA-3ihvA:
undetectable		 3w1wA-3ihvA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 11 GLY A 489
PRO A 390
ALA A 322
GLY A 307
ASN A 323
 CL  A   1 (-3.7A)
None
None
None
None
 1.24A 4a6nA-3ihvA:
undetectable		 4a6nA-3ihvA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 ALA A 202
LEU A 282
ILE A 283
SER A 210
GLY A 222
 None
None
EDO  A  23 ( 4.7A)
None
None
 1.06A 4dm8B-3ihvA:
undetectable		 4dm8B-3ihvA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 GLY A  60
ILE A 302
ASN A 306
GLN A 101
 None
 1.07A 4g0vA-3ihvA:
2.3		 4g0vA-3ihvA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 ASN A 384
GLN A 382
ASN A 523
TRP A 515
 None
 1.12A 4kcnB-3ihvA:
undetectable		 4kcnB-3ihvA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 4 ILE A 347
VAL A 327
VAL A 331
ARG A 343
 EDO  A   9 (-3.9A)
None
EDO  A   9 (-4.6A)
None
 1.01A 4m6tA-3ihvA:
undetectable		 4m6tA-3ihvA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 GLN A 351
SER A 358
ASP A 375
ASP A 377
 None
None
EDO  A   9 ( 4.8A)
None
 1.25A 4qtuB-3ihvA:
undetectable		 4qtuB-3ihvA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 LEU A 417
GLU A 488
LEU A 423
HIS A 258
 None
 1.34A 4xi3B-3ihvA:
undetectable		 4xi3B-3ihvA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 4 GLY A  80
LEU A  66
PHE A  67
ILE A  87
 None
 0.98A 4xv2A-3ihvA:
1.4		 4xv2A-3ihvA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 SER A 255
GLY A 256
ALA A 420
GLY A 259
 None
 0.79A 5albL-3ihvA:
undetectable		 5albL-3ihvA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 222
GLY A 218
ILE A 251
ILE A 283
LEU A 423
 None
None
None
EDO  A  23 ( 4.7A)
None
 1.14A 5fa8A-3ihvA:
undetectable		 5fa8A-3ihvA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 TRP A 393
ILE A  65
SER A  64
 None
 1.00A 5gqbA-3ihvA:
undetectable		 5gqbA-3ihvA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 497
HIS A 490
ARG A 481
 None
 1.12A 5iaoC-3ihvA:
undetectable		 5iaoC-3ihvA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 497
HIS A 490
ARG A 481
 None
 1.10A 5iaoF-3ihvA:
undetectable		 5iaoF-3ihvA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 THR A 203
PRO A 278
ASP A 277
 None
 0.94A 5l8dB-3ihvA:
undetectable		 5l8dB-3ihvA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 THR A 203
PRO A 278
ASP A 277
 None
 0.94A 5mwuB-3ihvA:
undetectable		 5mwuB-3ihvA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 ILE A 120
ALA A  39
LEU A 137
ILE A 124
 None
 0.82A 5uihA-3ihvA:
undetectable		 5uihA-3ihvA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 ASN A 384
GLN A 382
ASN A 523
TRP A 515
 None
 1.06A 5vunA-3ihvA:
undetectable		 5vunA-3ihvA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 ASN A 384
GLN A 382
ASN A 523
TRP A 515
 None
 1.06A 5vunB-3ihvA:
undetectable		 5vunB-3ihvA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 ASN A 384
GLN A 382
ASN A 523
TRP A 515
 None
 1.06A 5vuoB-3ihvA:
undetectable		 5vuoB-3ihvA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 ASP A 337
ILE A 347
ASN A 446
TYR A 453
 None
EDO  A   9 (-3.9A)
None
None
 1.24A 6a93B-3ihvA:
2.1		 6a93B-3ihvA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 ASN A 384
GLN A 382
ASN A 523
TRP A 515
 None
 1.09A 6auuB-3ihvA:
undetectable		 6auuB-3ihvA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A 184
VAL A 160
MET A  58
VAL A  49
THR A 166
 None
 1.17A 6brdC-3ihvA:
undetectable		 6brdC-3ihvA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 3ihv SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 9 ILE A 283
ALA A 219
GLY A 218
LEU A 221
GLY A 259
 EDO  A  23 ( 4.7A)
None
None
None
None
 1.33A 6nm4B-3ihvA:
undetectable		 6nm4B-3ihvA:
18.71