SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ihw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3ihw CENTG3
(Homo
sapiens) 		4 / 7 LEU A 180
LEU A 182
MET A 193
LEU A 222
 None
 1.09A 1kt3A-3ihwA:
undetectable		 1kt3A-3ihwA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3ihw CENTG3
(Homo
sapiens) 		5 / 12 LEU A 140
ASP A 244
VAL A 241
ALA A 106
VAL A 161
 None
 1.39A 2g70A-3ihwA:
undetectable		 2g70A-3ihwA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3ihw CENTG3
(Homo
sapiens) 		5 / 12 LEU A 140
ASP A 244
VAL A 241
ALA A 106
VAL A 161
 None
 1.43A 2g72A-3ihwA:
undetectable		 2g72A-3ihwA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3ihw CENTG3
(Homo
sapiens) 		4 / 5 VAL A 163
SER A 105
VAL A 108
SER A 102
 None
 1.30A 2j9cA-3ihwA:
undetectable
2j9cB-3ihwA:
undetectable
2j9cC-3ihwA:
undetectable		 2j9cA-3ihwA:
21.39
2j9cB-3ihwA:
21.39
2j9cC-3ihwA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 3ihw CENTG3
(Homo
sapiens) 		4 / 8 ASN A 187
ALA A 188
PRO A 192
LEU A 182
 None
None
UNX  A   3 ( 4.1A)
None
 0.96A 4jjkA-3ihwA:
6.5		 4jjkA-3ihwA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3ihw CENTG3
(Homo
sapiens) 		4 / 8 VAL A 245
VAL A  94
ILE A 142
LEU A 107
 None
 0.80A 4jq1B-3ihwA:
2.9		 4jq1B-3ihwA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 3ihw CENTG3
(Homo
sapiens) 		5 / 12 LEU A 182
GLY A  95
VAL A 191
SER A 102
GLY A 197
 None
 1.07A 5f9zA-3ihwA:
2.6		 5f9zA-3ihwA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 3ihw CENTG3
(Homo
sapiens) 		5 / 12 GLU A 120
THR A 230
GLY A 197
VAL A  94
ILE A 142
 None
 1.26A 5tuiB-3ihwA:
undetectable		 5tuiB-3ihwA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 3ihw CENTG3
(Homo
sapiens) 		4 / 7 VAL A 245
LEU A 151
PHE A 162
LEU A 182
 None
 1.05A 6aycA-3ihwA:
undetectable		 6aycA-3ihwA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 3ihw CENTG3
(Homo
sapiens) 		4 / 9 HIS A 109
LEU A  92
VAL A 132
SER A 137
 None
 0.84A 6c2mD-3ihwA:
undetectable		 6c2mD-3ihwA:
17.39