SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ihy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3
(Homo
sapiens) 		5 / 9 LEU A 641
VAL A 672
ILE A 634
ASP A 761
ILE A 760
 None
 1.42A 1gebA-3ihyA:
undetectable		 1gebA-3ihyA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3
(Homo
sapiens) 		4 / 6 LEU A 397
VAL A 734
ILE A 651
ARG A 811
 None
 1.01A 1opjB-3ihyA:
5.4		 1opjB-3ihyA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3
(Homo
sapiens) 		5 / 11 VAL A 842
PHE A 820
ILE A 765
GLY A 740
ILE A 735
 None
 1.03A 1z11A-3ihyA:
undetectable		 1z11A-3ihyA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3
(Homo
sapiens) 		5 / 11 VAL A 842
PHE A 820
ILE A 765
GLY A 740
ILE A 735
 None
 1.04A 1z11B-3ihyA:
undetectable		 1z11B-3ihyA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3
(Homo
sapiens) 		4 / 8 ILE A 863
TYR A 858
TYR A 737
CYH A 733
 None
 1.30A 2xz5C-3ihyA:
undetectable
2xz5D-3ihyA:
undetectable		 2xz5C-3ihyA:
17.00
2xz5D-3ihyA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3
(Homo
sapiens) 		4 / 7 ILE A 863
TYR A 858
TYR A 737
CYH A 733
 None
 1.28A 2xz5D-3ihyA:
undetectable
2xz5E-3ihyA:
undetectable		 2xz5D-3ihyA:
17.00
2xz5E-3ihyA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3
(Homo
sapiens) 		5 / 12 GLY A 716
GLY A 786
GLY A 788
ASN A 780
ILE A 700
 None
 1.04A 3eluA-3ihyA:
undetectable		 3eluA-3ihyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3
(Homo
sapiens) 		5 / 10 ARG A 320
ALA A 348
LEU A 330
LEU A 334
VAL A 337
 None
 1.18A 3o02A-3ihyA:
undetectable
3o02B-3ihyA:
undetectable		 3o02A-3ihyA:
21.50
3o02B-3ihyA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3
(Homo
sapiens) 		4 / 8 ILE A 738
ILE A 735
VAL A 842
ILE A 647
 None
 0.84A 3p4wC-3ihyA:
undetectable		 3p4wC-3ihyA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3
(Homo
sapiens) 		3 / 3 LEU A 577
MET A 583
ASP A 550
 None
 0.87A 3v5wA-3ihyA:
3.7		 3v5wA-3ihyA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3
(Homo
sapiens) 		4 / 7 LEU A 286
TYR A 321
ASP A 283
SER A 282
 None
 1.26A 4arcA-3ihyA:
undetectable		 4arcA-3ihyA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3
(Homo
sapiens) 		5 / 12 ASP A 830
GLY A 763
ASP A 761
GLY A 740
PRO A 770
 None
 1.16A 4blvA-3ihyA:
undetectable		 4blvA-3ihyA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3
(Homo
sapiens) 		4 / 8 TYR A 858
TYR A 737
CYH A 733
ILE A 863
 None
 1.25A 4bqtC-3ihyA:
undetectable
4bqtD-3ihyA:
undetectable		 4bqtC-3ihyA:
16.84
4bqtD-3ihyA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3
(Homo
sapiens) 		3 / 3 TYR A 764
ARG A 744
HIS A 745
 None
 1.08A 4fubA-3ihyA:
undetectable		 4fubA-3ihyA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3
(Homo
sapiens) 		4 / 8 LEU A 665
MET A 777
MET A 859
ILE A 650
 None
 0.99A 4ok1A-3ihyA:
undetectable		 4ok1A-3ihyA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3
(Homo
sapiens) 		6 / 9 LEU A 577
ALA A 609
LEU A 573
ALA A 619
LEU A 552
LEU A 585
 None
 1.14A 4z91F-3ihyA:
2.6
4z91G-3ihyA:
2.7
4z91H-3ihyA:
2.6
4z91I-3ihyA:
2.6
4z91J-3ihyA:
1.8		 4z91F-3ihyA:
20.03
4z91G-3ihyA:
20.03
4z91H-3ihyA:
20.03
4z91I-3ihyA:
20.03
4z91J-3ihyA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3
(Homo
sapiens) 		4 / 7 ALA A 805
THR A 804
VAL A 856
LYS A 800
 None
 1.16A 5ecnA-3ihyA:
undetectable		 5ecnA-3ihyA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3
(Homo
sapiens) 		5 / 12 LEU A 595
LEU A 577
LEU A 585
PHE A 681
ALA A 619
 None
 1.39A 5ieoA-3ihyA:
undetectable		 5ieoA-3ihyA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3
(Homo
sapiens) 		4 / 6 VAL A 381
SER A 481
ARG A 523
PHE A 524
 None
 0.98A 5jw1B-3ihyA:
undetectable		 5jw1B-3ihyA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3
(Homo
sapiens) 		4 / 5 SER A 369
ASN A 827
GLN A 401
ASP A 505
 None
 1.39A 5kpcA-3ihyA:
undetectable		 5kpcA-3ihyA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3
(Homo
sapiens) 		5 / 12 GLY A 742
PRO A 775
ASP A 769
PRO A 770
LYS A 771
 None
 1.13A 5x6yC-3ihyA:
undetectable		 5x6yC-3ihyA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3
(Homo
sapiens) 		4 / 6 TYR A 517
LEU A 399
GLU A 406
LEU A 475
 None
 1.42A 5xooA-3ihyA:
undetectable		 5xooA-3ihyA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3
(Homo
sapiens) 		5 / 10 ASN A 827
LEU A 766
LEU A 833
ALA A 832
GLU A 500
 None
 1.13A 5y7pG-3ihyA:
undetectable		 5y7pG-3ihyA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3
(Homo
sapiens) 		4 / 5 TYR A 670
GLN A 683
GLY A 731
ILE A 651
 None
 1.44A 6debB-3ihyA:
undetectable		 6debB-3ihyA:
9.84