SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ii6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 3ii6 DNA LIGASE 4
(Homo
sapiens) 		6 / 12 GLU X 660
ILE X 682
PHE X 685
VAL X 721
ILE X 701
PHE X 730
 None
 1.07A 1c9hA-3ii6X:
undetectable		 1c9hA-3ii6X:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 3ii6 DNA LIGASE 4
(Homo
sapiens) 		4 / 8 GLY X 866
PHE X 882
PHE X 875
PHE X 886
 None
 0.93A 3ko0D-3ii6X:
undetectable
3ko0E-3ii6X:
undetectable		 3ko0D-3ii6X:
17.36
3ko0E-3ii6X:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 3ii6 DNA LIGASE 4
(Homo
sapiens) 		4 / 7 GLY X 866
PHE X 882
PHE X 875
PHE X 886
 None
 0.87A 3ko0L-3ii6X:
undetectable
3ko0N-3ii6X:
undetectable		 3ko0L-3ii6X:
17.36
3ko0N-3ii6X:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 3ii6 DNA LIGASE 4
(Homo
sapiens) 		5 / 12 GLY X 866
ALA X 839
ALA X 842
LEU X 889
LEU X 820
 None
 1.07A 3p2kC-3ii6X:
undetectable		 3p2kC-3ii6X:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CUT_A_TYLA2971_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 3ii6 DNA LIGASE 4
(Homo
sapiens) 		4 / 4 VAL X 863
VAL X 860
ASN X 827
ILE X 826
 None
 1.36A 4cutA-3ii6X:
undetectable		 4cutA-3ii6X:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		 3ii6 DNA LIGASE 4
(Homo
sapiens) 		4 / 8 TYR X 698
THR X 697
TRP X 725
TRP X 738
 None
 1.48A 4tzcB-3ii6X:
undetectable
4tzcD-3ii6X:
undetectable		 4tzcB-3ii6X:
18.29
4tzcD-3ii6X:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 3ii6 DNA LIGASE 4
(Homo
sapiens) 		6 / 12 GLU X 660
ILE X 682
PHE X 685
VAL X 721
ILE X 701
PHE X 730
 None
 1.07A 5hkgA-3ii6X:
undetectable		 5hkgA-3ii6X:
17.49