SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ii7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 3ii7 KELCH-LIKE PROTEIN 7
(Homo
sapiens) 		4 / 4 HIS A 474
ALA A 485
PHE A 484
GLY A 475
 None
 1.32A 1mj2B-3ii7A:
undetectable		 1mj2B-3ii7A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 3ii7 KELCH-LIKE PROTEIN 7
(Homo
sapiens) 		4 / 4 HIS A 474
ALA A 485
PHE A 484
GLY A 475
 None
 1.36A 1mj2D-3ii7A:
undetectable		 1mj2D-3ii7A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 3ii7 KELCH-LIKE PROTEIN 7
(Homo
sapiens) 		4 / 4 HIS A 474
ALA A 485
PHE A 484
GLY A 475
 None
 1.33A 1mjoB-3ii7A:
undetectable		 1mjoB-3ii7A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 3ii7 KELCH-LIKE PROTEIN 7
(Homo
sapiens) 		4 / 4 HIS A 474
ALA A 485
PHE A 484
GLY A 475
 None
 1.26A 1mjoA-3ii7A:
undetectable		 1mjoA-3ii7A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 3ii7 KELCH-LIKE PROTEIN 7
(Homo
sapiens) 		4 / 4 HIS A 474
ALA A 485
PHE A 484
GLY A 475
 None
 1.33A 1mjoD-3ii7A:
undetectable		 1mjoD-3ii7A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3ii7 KELCH-LIKE PROTEIN 7
(Homo
sapiens) 		5 / 12 SER A 422
GLY A 424
VAL A 447
LEU A 448
GLY A 436
 None
None
EDO  A 961 (-3.9A)
None
None
 0.92A 1uakA-3ii7A:
undetectable		 1uakA-3ii7A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 3ii7 KELCH-LIKE PROTEIN 7
(Homo
sapiens) 		5 / 10 ILE A 545
ALA A 563
ILE A 571
PRO A 311
ILE A 295
 None
 1.31A 2dm6A-3ii7A:
undetectable
2dm6B-3ii7A:
undetectable		 2dm6A-3ii7A:
23.89
2dm6B-3ii7A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 3ii7 KELCH-LIKE PROTEIN 7
(Homo
sapiens) 		4 / 8 GLY A 487
HIS A 474
ASN A 490
GLU A 499
 None
None
EDO  A 961 (-3.7A)
None
 0.94A 2x0pA-3ii7A:
undetectable		 2x0pA-3ii7A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 3ii7 KELCH-LIKE PROTEIN 7
(Homo
sapiens) 		4 / 6 TYR A 385
CYH A 378
VAL A 434
PHE A 400
 None
 1.31A 3ltwA-3ii7A:
undetectable		 3ltwA-3ii7A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3ii7 KELCH-LIKE PROTEIN 7
(Homo
sapiens) 		4 / 7 GLY A 437
GLY A 436
MET A 467
ASN A 449
 None
 1.06A 4fgkB-3ii7A:
undetectable		 4fgkB-3ii7A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3ii7 KELCH-LIKE PROTEIN 7
(Homo
sapiens) 		5 / 10 LEU A 546
VAL A 521
VAL A 498
GLY A 487
LEU A 542
 None
 1.45A 6bsiA-3ii7A:
undetectable		 6bsiA-3ii7A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 3ii7 KELCH-LIKE PROTEIN 7
(Homo
sapiens) 		5 / 12 ALA A 525
THR A 552
PHE A 484
VAL A 477
VAL A 426
 EDO  A 955 (-3.9A)
None
None
EDO  A 955 (-4.0A)
None
 1.40A 6hu9N-3ii7A:
undetectable		 6hu9N-3ii7A:
22.91