SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iib'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 3iib PEPTIDASE M28
(Shewanella
amazonensis) 		3 / 3 ALA A 450
VAL A 452
TRP A 451
 None
 0.84A 1bdwA-3iibA:
undetectable
1bdwB-3iibA:
undetectable		 1bdwA-3iibA:
3.54
1bdwB-3iibA:
3.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MF1_A_ACTA458_0
(ADENYLOSUCCINATE
SYNTHETASE)		 3iib PEPTIDASE M28
(Shewanella
amazonensis) 		4 / 4 GLY A 167
LYS A 168
GLY A 169
HIS A 164
 None
 0.98A 1mf1A-3iibA:
undetectable		 1mf1A-3iibA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 3iib PEPTIDASE M28
(Shewanella
amazonensis) 		5 / 10 ARG A  60
LEU A 281
VAL A 300
ILE A 299
ILE A 434
 None
 1.01A 1q6iB-3iibA:
undetectable		 1q6iB-3iibA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3iib PEPTIDASE M28
(Shewanella
amazonensis) 		4 / 8 LEU A  53
VAL A  57
GLY A  58
ASP A 282
 None
 0.82A 2a1oA-3iibA:
undetectable		 2a1oA-3iibA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3iib PEPTIDASE M28
(Shewanella
amazonensis) 		4 / 8 PHE A  83
LEU A 308
ILE A 307
HIS A 306
 None
None
None
PGE  A   3 ( 4.6A)
 0.90A 2azxA-3iibA:
undetectable		 2azxA-3iibA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 3iib PEPTIDASE M28
(Shewanella
amazonensis) 		3 / 3 ARG A 414
GLY A 397
PRO A 398
 None
 0.65A 2hreD-3iibA:
undetectable		 2hreD-3iibA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 3iib PEPTIDASE M28
(Shewanella
amazonensis) 		5 / 9 LEU A 139
ILE A 133
GLY A 191
ILE A 219
ILE A 157
 None
 1.19A 2r5qA-3iibA:
undetectable		 2r5qA-3iibA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 3iib PEPTIDASE M28
(Shewanella
amazonensis) 		5 / 9 LEU A 139
ILE A 133
GLY A 191
ILE A 219
ILE A 157
 None
 1.19A 2r5qC-3iibA:
undetectable		 2r5qC-3iibA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VFT_A_SORA1419_0
(XYLITOL OXIDASE)		 3iib PEPTIDASE M28
(Shewanella
amazonensis) 		5 / 12 PRO A  90
VAL A  91
THR A 335
GLU A 339
HIS A 340
 None
 1.43A 2vftA-3iibA:
0.0		 2vftA-3iibA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3iib PEPTIDASE M28
(Shewanella
amazonensis) 		3 / 3 TYR A 336
GLU A 343
THR A 317
 None
 0.96A 2y7hB-3iibA:
undetectable		 2y7hB-3iibA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 3iib PEPTIDASE M28
(Shewanella
amazonensis) 		5 / 12 PRO A 125
THR A 124
ILE A 219
ILE A 154
ALA A 155
 None
 0.90A 3a50A-3iibA:
undetectable		 3a50A-3iibA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 3iib PEPTIDASE M28
(Shewanella
amazonensis) 		4 / 5 ASN A 442
ALA A 411
LEU A 276
GLY A 278
 None
 0.77A 3dl9A-3iibA:
undetectable		 3dl9A-3iibA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3iib PEPTIDASE M28
(Shewanella
amazonensis) 		5 / 12 ALA A 189
ILE A 219
SER A 121
LEU A 248
ILE A 193
 None
 1.20A 3qfxA-3iibA:
undetectable		 3qfxA-3iibA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3iib PEPTIDASE M28
(Shewanella
amazonensis) 		5 / 12 ALA A 189
ILE A 219
SER A 121
LEU A 248
ILE A 193
 None
 1.18A 3qfxB-3iibA:
undetectable		 3qfxB-3iibA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3iib PEPTIDASE M28
(Shewanella
amazonensis) 		4 / 6 THR A 173
GLY A 176
ARG A 135
ILE A 194
 None
None
PEG  A   4 (-3.8A)
None
 1.26A 4acaC-3iibA:
2.9		 4acaC-3iibA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3iib PEPTIDASE M28
(Shewanella
amazonensis) 		5 / 12 GLY A 176
SER A 175
ASP A 141
ALA A 184
PHE A 156
 None
 1.14A 4dx5B-3iibA:
undetectable		 4dx5B-3iibA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 3iib PEPTIDASE M28
(Shewanella
amazonensis) 		4 / 7 ASP A 292
GLU A 327
HIS A 425
GLU A 326
 ZN  A   1 ( 2.5A)
ZN  A   1 (-2.0A)
ZN  A   1 (-3.5A)
ZN  A   2 ( 3.8A)
 1.05A 4hvrA-3iibA:
undetectable		 4hvrA-3iibA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3iib PEPTIDASE M28
(Shewanella
amazonensis) 		4 / 7 GLU A 343
GLU A 339
GLU A  89
ARG A 319
 None
 1.07A 4mi4B-3iibA:
undetectable
4mi4C-3iibA:
undetectable		 4mi4B-3iibA:
16.85
4mi4C-3iibA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3iib PEPTIDASE M28
(Shewanella
amazonensis) 		4 / 8 GLU A 343
GLU A 339
GLU A  89
ARG A 319
 None
 1.07A 4mj8B-3iibA:
undetectable
4mj8C-3iibA:
undetectable		 4mj8B-3iibA:
16.67
4mj8C-3iibA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3iib PEPTIDASE M28
(Shewanella
amazonensis) 		4 / 6 PHE A 449
MET A 379
ARG A 316
VAL A 367
 None
 1.37A 4mk4B-3iibA:
2.2		 4mk4B-3iibA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3iib PEPTIDASE M28
(Shewanella
amazonensis) 		4 / 5 GLY A  63
ASP A  67
GLU A 327
VAL A 297
 None
None
ZN  A   1 (-2.0A)
None
 1.17A 4nkvD-3iibA:
undetectable		 4nkvD-3iibA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 3iib PEPTIDASE M28
(Shewanella
amazonensis) 		6 / 11 HIS A 280
ASP A 292
GLU A 326
GLU A 327
GLY A 171
HIS A 425
 ZN  A   2 (-3.3A)
ZN  A   1 ( 2.5A)
ZN  A   2 ( 3.8A)
ZN  A   1 (-2.0A)
None
ZN  A   1 (-3.5A)
 0.68A 4pqaA-3iibA:
19.6		 4pqaA-3iibA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 3iib PEPTIDASE M28
(Shewanella
amazonensis) 		5 / 11 HIS A 280
ASP A 292
GLU A 327
GLY A 167
HIS A 425
 ZN  A   2 (-3.3A)
ZN  A   1 ( 2.5A)
ZN  A   1 (-2.0A)
None
ZN  A   1 (-3.5A)
 0.82A 4pqaA-3iibA:
19.6		 4pqaA-3iibA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3iib PEPTIDASE M28
(Shewanella
amazonensis) 		5 / 12 GLY A 176
SER A 175
ASP A 141
ALA A 184
PHE A 156
 None
 1.13A 4u8yB-3iibA:
undetectable		 4u8yB-3iibA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3iib PEPTIDASE M28
(Shewanella
amazonensis) 		5 / 12 ILE A 105
SER A 121
ILE A 100
ALA A 101
ALA A 222
 None
 1.24A 5oy02-3iibA:
undetectable		 5oy02-3iibA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3iib PEPTIDASE M28
(Shewanella
amazonensis) 		4 / 6 GLN A 441
VAL A 443
ALA A 302
THR A 301
 None
 1.03A 6cduB-3iibA:
undetectable
6cduC-3iibA:
undetectable		 6cduB-3iibA:
20.17
6cduC-3iibA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3iib PEPTIDASE M28
(Shewanella
amazonensis) 		4 / 7 HIS A 206
ARG A 163
HIS A 164
ASP A 422
 None
 1.19A 6mn4F-3iibA:
undetectable		 6mn4F-3iibA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3iib PEPTIDASE M28
(Shewanella
amazonensis) 		4 / 7 ASP A 166
ARG A 414
TYR A 361
ASP A 364
 None
 1.28A 6mn5E-3iibA:
undetectable		 6mn5E-3iibA:
12.01