SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iiw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 3iiw POLYCOMB PROTEIN EED
(Homo
sapiens) 		3 / 3 ASP A 338
PHE A 299
VAL A 350
 None
 0.65A 1kijB-3iiwA:
undetectable		 1kijB-3iiwA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3iiw POLYCOMB PROTEIN EED
(Homo
sapiens) 		4 / 6 PHE A 198
ALA A 164
TYR A 186
ILE A 183
 None
 1.17A 1oniH-3iiwA:
undetectable
1oniI-3iiwA:
undetectable		 1oniH-3iiwA:
16.21
1oniI-3iiwA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3iiw POLYCOMB PROTEIN EED
(Homo
sapiens) 		4 / 7 TYR A 186
ILE A 183
PHE A 198
ALA A 164
 None
 0.98A 1oniG-3iiwA:
undetectable
1oniI-3iiwA:
undetectable		 1oniG-3iiwA:
16.21
1oniI-3iiwA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3iiw POLYCOMB PROTEIN EED
(Homo
sapiens) 		4 / 6 ARG A 169
ILE A 171
GLY A 170
ALA A 192
 None
 0.89A 1wmqA-3iiwA:
undetectable		 1wmqA-3iiwA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3iiw POLYCOMB PROTEIN EED
(Homo
sapiens) 		4 / 6 ARG A 169
ILE A 171
GLY A 170
ALA A 192
 None
 0.89A 1wmqB-3iiwA:
undetectable		 1wmqB-3iiwA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3iiw POLYCOMB PROTEIN EED
(Homo
sapiens) 		4 / 6 ARG A 169
ILE A 171
GLY A 170
ALA A 192
 None
 0.89A 1wpuA-3iiwA:
undetectable		 1wpuA-3iiwA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3iiw POLYCOMB PROTEIN EED
(Homo
sapiens) 		4 / 6 ARG A 169
ILE A 171
GLY A 170
ALA A 192
 None
 0.89A 1wpuB-3iiwA:
undetectable		 1wpuB-3iiwA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3iiw POLYCOMB PROTEIN EED
(Homo
sapiens) 		5 / 12 ILE A 172
ALA A 164
ASN A 219
LEU A 196
ALA A 151
 None
 1.13A 1xdkA-3iiwA:
undetectable		 1xdkA-3iiwA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 3iiw POLYCOMB PROTEIN EED
(Homo
sapiens) 		4 / 5 ASP A 341
ILE A 340
GLU A 249
LYS A 250
 None
 1.22A 2xrzA-3iiwA:
undetectable
2xrzB-3iiwA:
undetectable		 2xrzA-3iiwA:
22.06
2xrzB-3iiwA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3iiw POLYCOMB PROTEIN EED
(Homo
sapiens) 		4 / 7 SER A 419
LEU A 135
ILE A 426
PHE A 113
 None
 0.98A 3ln1C-3iiwA:
undetectable		 3ln1C-3iiwA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3iiw POLYCOMB PROTEIN EED
(Homo
sapiens) 		3 / 3 ASN A 102
TRP A 152
ASP A 109
 None
 1.23A 4a7tA-3iiwA:
undetectable
4a7tF-3iiwA:
undetectable		 4a7tA-3iiwA:
17.90
4a7tF-3iiwA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3iiw POLYCOMB PROTEIN EED
(Homo
sapiens) 		5 / 12 ASP A 257
HIS A 213
GLY A 234
SER A 259
HIS A 295
 None
 1.22A 4blvB-3iiwA:
undetectable		 4blvB-3iiwA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 3iiw POLYCOMB PROTEIN EED
(Homo
sapiens) 		4 / 8 SER A 241
CYH A 311
PHE A 368
GLN A 100
 None
 0.82A 4j7uD-3iiwA:
undetectable		 4j7uD-3iiwA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3iiw POLYCOMB PROTEIN EED
(Homo
sapiens) 		3 / 3 LEU A 163
PHE A 198
ILE A 174
 None
 0.77A 5dzk1-3iiwA:
undetectable
5dzkF-3iiwA:
undetectable
5dzkM-3iiwA:
undetectable		 5dzk1-3iiwA:
3.39
5dzkF-3iiwA:
22.50
5dzkM-3iiwA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 3iiw POLYCOMB PROTEIN EED
(Homo
sapiens) 		3 / 3 ILE A 193
MET A 256
ASP A 212
 None
 0.72A 5h2uA-3iiwA:
undetectable		 5h2uA-3iiwA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3iiw POLYCOMB PROTEIN EED
(Homo
sapiens) 		4 / 7 HIS A 189
HIS A 185
ILE A 172
ARG A 216
 None
 1.12A 5kkzC-3iiwA:
1.0
5kkzE-3iiwA:
undetectable		 5kkzC-3iiwA:
18.21
5kkzE-3iiwA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3iiw POLYCOMB PROTEIN EED
(Homo
sapiens) 		4 / 7 HIS A 185
ILE A 172
ARG A 216
HIS A 189
 None
 1.12A 5kkzK-3iiwA:
undetectable
5kkzQ-3iiwA:
1.1		 5kkzK-3iiwA:
20.67
5kkzQ-3iiwA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3iiw POLYCOMB PROTEIN EED
(Homo
sapiens) 		4 / 7 HIS A 189
HIS A 185
ILE A 172
ARG A 216
 None
 1.15A 5kkzM-3iiwA:
1.1
5kkzO-3iiwA:
undetectable		 5kkzM-3iiwA:
18.21
5kkzO-3iiwA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 3iiw POLYCOMB PROTEIN EED
(Homo
sapiens) 		3 / 3 LYS A 322
GLN A 360
ASN A 381
 None
 0.97A 5l2tA-3iiwA:
undetectable		 5l2tA-3iiwA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3iiw POLYCOMB PROTEIN EED
(Homo
sapiens) 		3 / 3 VAL A 121
VAL A 116
GLN A 100
 None
 0.67A 5qgmA-3iiwA:
undetectable		 5qgmA-3iiwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3iiw POLYCOMB PROTEIN EED
(Homo
sapiens) 		5 / 12 GLU A 238
VAL A 239
LEU A 225
SER A 253
GLY A 231
 None
 1.04A 5syeB-3iiwA:
undetectable		 5syeB-3iiwA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3iiw POLYCOMB PROTEIN EED
(Homo
sapiens) 		4 / 6 LYS A 385
LEU A 386
LEU A 425
PHE A  82
 None
 1.12A 5w97C-3iiwA:
undetectable
5w97J-3iiwA:
undetectable		 5w97C-3iiwA:
19.63
5w97J-3iiwA:
12.54