SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ij3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		3 / 3 THR A 305
PRO A 290
THR A 307
 None
 0.96A 1dscC-3ij3A:
undetectable		 1dscC-3ij3A:
2.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		4 / 6 VAL A 224
GLY A 225
ALA A 318
LEU A 319
 None
 0.75A 1e7bB-3ij3A:
undetectable		 1e7bB-3ij3A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_2
(HMG-COA REDUCTASE)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		5 / 11 ASN A 354
SER A 357
LEU A 358
ALA A 361
LEU A 362
 None
PGE  A 471 (-4.8A)
PGE  A 471 ( 4.3A)
PGE  A 471 ( 3.9A)
None
 1.48A 1hwkB-3ij3A:
0.2		 1hwkB-3ij3A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_B_117B1_1
(HMG-COA REDUCTASE)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		5 / 11 ASN A 354
SER A 357
LEU A 358
ALA A 361
LEU A 362
 None
PGE  A 471 (-4.8A)
PGE  A 471 ( 4.3A)
PGE  A 471 ( 3.9A)
None
 1.48A 1hwkA-3ij3A:
undetectable		 1hwkA-3ij3A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_2
(HMG-COA REDUCTASE)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		5 / 11 ASN A 354
SER A 357
LEU A 358
ALA A 361
LEU A 362
 None
PGE  A 471 (-4.8A)
PGE  A 471 ( 4.3A)
PGE  A 471 ( 3.9A)
None
 1.48A 1hwkD-3ij3A:
0.7		 1hwkD-3ij3A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_1
(HMG-COA REDUCTASE)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		5 / 11 ASN A 354
SER A 357
LEU A 358
ALA A 361
LEU A 362
 None
PGE  A 471 (-4.8A)
PGE  A 471 ( 4.3A)
PGE  A 471 ( 3.9A)
None
 1.49A 1hwkC-3ij3A:
0.5		 1hwkC-3ij3A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		4 / 8 ARG A 122
ASN A 117
ASN A 154
ASP A 151
 None
 1.21A 1rs6A-3ij3A:
undetectable		 1rs6A-3ij3A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		4 / 8 ARG A 122
ASN A 117
ASN A 154
ASP A 151
 None
 1.22A 1rs6B-3ij3A:
undetectable		 1rs6B-3ij3A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		4 / 8 PHE A 424
ILE A 331
GLY A 225
PHE A 333
 None
 0.76A 1rtsA-3ij3A:
undetectable		 1rtsA-3ij3A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		4 / 8 ARG A 122
ASN A 117
ASN A 154
ASP A 151
 None
 1.20A 1zzqB-3ij3A:
undetectable		 1zzqB-3ij3A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		5 / 12 GLY A 403
SER A 397
ALA A 343
ALA A 404
ASP A 425
 SO4  A 463 (-3.3A)
SO4  A 463 (-2.8A)
None
None
None
 1.45A 2avdA-3ij3A:
undetectable		 2avdA-3ij3A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		5 / 12 LEU A 411
VAL A 323
GLY A 225
LEU A 453
TYR A 457
 None
 1.04A 2cbrA-3ij3A:
undetectable		 2cbrA-3ij3A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		5 / 12 LEU A 275
VAL A 224
GLY A 225
GLY A 227
ALA A 318
 None
 0.85A 2egvA-3ij3A:
undetectable		 2egvA-3ij3A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		5 / 12 LEU A 275
VAL A 224
GLY A 225
GLY A 227
ALA A 318
 None
 0.87A 2egvB-3ij3A:
undetectable		 2egvB-3ij3A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		5 / 12 ALA A 157
GLY A 161
ASN A 281
GLY A 225
LEU A 315
 None
 0.96A 2hw2A-3ij3A:
undetectable		 2hw2A-3ij3A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		5 / 12 ASP A 151
ILE A 153
GLY A 441
GLY A 440
ILE A 439
 None
 1.02A 2o4kA-3ij3A:
undetectable		 2o4kA-3ij3A:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		4 / 6 LEU A 111
ILE A 146
ILE A 331
LEU A 373
 None
 0.97A 2xkwB-3ij3A:
undetectable		 2xkwB-3ij3A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		4 / 6 LEU A 207
ILE A 209
ILE A 331
LEU A 319
 None
 0.95A 2xkwB-3ij3A:
undetectable		 2xkwB-3ij3A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		3 / 3 SER A 123
ARG A 122
GLN A 115
 EDO  A 467 (-2.9A)
None
EDO  A 467 ( 4.7A)
 0.94A 2xnrA-3ij3A:
undetectable		 2xnrA-3ij3A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		3 / 3 ARG A 120
ASP A 151
ASN A 117
 None
 0.89A 2zzmA-3ij3A:
undetectable		 2zzmA-3ij3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		3 / 3 THR A 305
PRO A 290
THR A 307
 None
 0.75A 316dC-3ij3A:
undetectable		 316dC-3ij3A:
2.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		4 / 5 ASN A 281
ALA A 157
LEU A 165
GLY A 227
 None
 0.95A 3dl9A-3ij3A:
undetectable		 3dl9A-3ij3A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		5 / 10 GLY A 252
ALA A 253
GLY A 258
LEU A 259
ILE A 276
 None
 0.78A 3em3A-3ij3A:
undetectable		 3em3A-3ij3A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		5 / 11 GLY A 252
ALA A 253
GLY A 258
LEU A 259
ILE A 276
 None
 0.88A 3em4U-3ij3A:
undetectable		 3em4U-3ij3A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		4 / 5 SER A 285
ARG A 286
ARG A 204
GLU A 158
 SO4  A 462 (-2.7A)
SO4  A 462 ( 4.3A)
None
None
 1.34A 3k9fA-3ij3A:
undetectable
3k9fB-3ij3A:
undetectable
3k9fC-3ij3A:
2.4		 3k9fA-3ij3A:
22.10
3k9fB-3ij3A:
22.10
3k9fC-3ij3A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		5 / 12 GLY A 225
GLY A 252
VAL A 228
ALA A 318
PHE A 424
 None
 0.95A 3mteB-3ij3A:
undetectable		 3mteB-3ij3A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		4 / 8 ARG A 122
ASN A 117
ASN A 154
ASP A 151
 None
 1.20A 3n62A-3ij3A:
undetectable		 3n62A-3ij3A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		4 / 8 ARG A 122
ASN A 117
ASN A 154
ASP A 151
 None
 1.23A 3n62B-3ij3A:
undetectable		 3n62B-3ij3A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		4 / 8 ARG A 122
ASN A 117
ASN A 154
ASP A 151
 None
 1.28A 3n66B-3ij3A:
undetectable		 3n66B-3ij3A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		5 / 12 GLY A 225
GLY A 252
VAL A 228
ALA A 318
PHE A 424
 None
 0.95A 3p2kC-3ij3A:
undetectable		 3p2kC-3ij3A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		3 / 3 ARG A 271
ARG A 273
ILE A 216
 PG4  A 472 ( 3.5A)
None
None
 0.89A 4b7qA-3ij3A:
undetectable		 4b7qA-3ij3A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		4 / 4 SER A 334
ASP A 231
MET A 246
ASP A 236
 SO4  A 461 ( 3.8A)
LI  A 460 (-3.1A)
None
None
 1.27A 4iv0A-3ij3A:
1.1		 4iv0A-3ij3A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		5 / 12 PHE A 352
ALA A 422
LEU A 376
GLY A 252
LEU A 336
 None
 1.24A 4kykA-3ij3A:
0.4
4kykB-3ij3A:
undetectable		 4kykA-3ij3A:
19.68
4kykB-3ij3A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		4 / 4 SER A 334
ASP A 231
MET A 246
ASP A 236
 SO4  A 461 ( 3.8A)
LI  A 460 (-3.1A)
None
None
 1.27A 4mwzB-3ij3A:
0.6		 4mwzB-3ij3A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		4 / 7 ILE A 182
LEU A 188
ALA A 278
ILE A 209
 None
 0.83A 4y03A-3ij3A:
undetectable		 4y03A-3ij3A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		5 / 9 THR A 335
ILE A 426
GLY A 225
LEU A 165
LEU A 152
 None
None
None
None
PEG  A 469 (-4.9A)
 1.26A 4ze0A-3ij3A:
undetectable		 4ze0A-3ij3A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		4 / 7 PHE A 424
ILE A 331
GLY A 225
PHE A 333
 None
 0.82A 5h3aA-3ij3A:
undetectable		 5h3aA-3ij3A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		4 / 8 ASP A  76
PHE A  77
ASN A  92
PHE A  96
 None
 0.97A 5mvsB-3ij3A:
undetectable		 5mvsB-3ij3A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		4 / 8 LEU A 411
VAL A 313
LEU A 386
ILE A 302
 None
None
EDO  A 466 ( 4.9A)
None
 0.97A 5v0vA-3ij3A:
undetectable		 5v0vA-3ij3A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		4 / 8 ARG A 122
ASN A 117
ASN A 154
ASP A 151
 None
 1.28A 5vunA-3ij3A:
undetectable		 5vunA-3ij3A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		4 / 8 ARG A 122
ASN A 117
ASN A 154
ASP A 151
 None
 1.25A 5vuoB-3ij3A:
undetectable		 5vuoB-3ij3A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		4 / 8 PHE A 424
ILE A 331
GLY A 225
PHE A 333
 None
 0.79A 5x5qD-3ij3A:
undetectable		 5x5qD-3ij3A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		4 / 8 PHE A 424
ILE A 331
GLY A 225
PHE A 333
 None
 0.78A 5x5qF-3ij3A:
undetectable		 5x5qF-3ij3A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		5 / 12 HIS A 255
ARG A 341
GLY A 338
GLY A 252
GLY A 251
 None
SO4  A 461 ( 3.6A)
None
None
None
 1.10A 6brdB-3ij3A:
undetectable		 6brdB-3ij3A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		4 / 9 VAL A 172
HIS A 171
LEU A 259
VAL A 224
 None
 0.90A 6c2mD-3ij3A:
undetectable		 6c2mD-3ij3A:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		5 / 12 GLY A  67
SER A  74
PHE A  77
VAL A  64
ASP A  95
 None
 1.18A 6clxA-3ij3A:
undetectable		 6clxA-3ij3A:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		4 / 4 LEU A 235
ASP A 292
PRO A 290
ARG A 289
 None
 1.19A 6fgdA-3ij3A:
undetectable		 6fgdA-3ij3A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 3ij3 CYTOSOL
AMINOPEPTIDASE
(Coxiella
burnetii) 		5 / 11 ILE A  16
LEU A 106
GLY A 110
SER A 113
ALA A 127
 None
 1.30A 6ieyA-3ij3A:
3.6
6ieyB-3ij3A:
3.8		 6ieyA-3ij3A:
22.22
6ieyB-3ij3A:
22.22