SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ikm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 636
THR A 638
PRO A 635
 None
 0.78A 1a7yA-3ikmA:
undetectable		 1a7yA-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 638
PRO A 635
THR A 636
 None
 0.66A 1a7yB-3ikmA:
undetectable		 1a7yB-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 636
THR A 638
PRO A 635
 None
 0.75A 1a7yB-3ikmA:
undetectable		 1a7yB-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 638
PRO A 635
THR A 636
 None
 0.78A 1dscC-3ikmA:
undetectable		 1dscC-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 636
THR A 638
PRO A 635
 None
 0.70A 1dscC-3ikmA:
undetectable		 1dscC-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 636
THR A 638
PRO A 635
 None
 0.77A 1fjaC-3ikmA:
undetectable		 1fjaC-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 636
THR A 638
PRO A 635
 None
 0.77A 1fjaD-3ikmA:
undetectable		 1fjaD-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_A_SALA3005_1
(XANTHINE
DEHYDROGENASE)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 9 LEU A 435
SER A 433
PHE A1129
VAL A 844
LEU A 860
 None
 1.45A 1fo4A-3ikmA:
undetectable		 1fo4A-3ikmA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 638
PRO A 635
THR A 636
 None
 0.80A 1i3wE-3ikmA:
undetectable		 1i3wE-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 636
THR A 638
PRO A 635
 None
 0.70A 1i3wE-3ikmA:
undetectable		 1i3wE-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 636
THR A 638
PRO A 635
 None
 0.76A 1i3wF-3ikmA:
undetectable		 1i3wF-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 638
PRO A 635
THR A 636
 None
 0.74A 1i3wG-3ikmA:
undetectable		 1i3wG-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 636
THR A 638
PRO A 635
 None
 0.67A 1i3wG-3ikmA:
undetectable		 1i3wG-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 636
THR A 638
PRO A 635
 None
 0.67A 1i3wH-3ikmA:
undetectable		 1i3wH-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 638
PRO A 635
THR A 636
 None
 0.67A 1mnvD-3ikmA:
undetectable		 1mnvD-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 636
THR A 638
PRO A 635
 None
 0.74A 1mnvD-3ikmA:
undetectable		 1mnvD-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 638
PRO A 635
THR A 636
 None
 0.81A 1ovfB-3ikmA:
undetectable		 1ovfB-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		4 / 7 VAL A1177
VAL A 901
LEU A 902
LEU A1173
 None
 0.88A 1pthA-3ikmA:
undetectable		 1pthA-3ikmA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		4 / 7 VAL A1177
VAL A 901
LEU A 902
LEU A1173
 None
 0.87A 1pthB-3ikmA:
undetectable		 1pthB-3ikmA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 636
THR A 638
PRO A 635
 None
 0.78A 1qfiA-3ikmA:
undetectable		 1qfiA-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 636
THR A 638
PRO A 635
 None
 0.79A 1qfiB-3ikmA:
undetectable		 1qfiB-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 12 THR A 294
GLY A 268
ASN A 270
HIS A 269
VAL A 366
 None
 1.10A 1r30B-3ikmA:
undetectable		 1r30B-3ikmA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 12 PRO A1203
GLY A 871
ALA A 448
PRO A 867
ALA A 865
 None
 1.16A 1sg9C-3ikmA:
undetectable		 1sg9C-3ikmA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 638
PRO A 635
THR A 636
 None
 0.63A 1unjF-3ikmA:
undetectable		 1unjF-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 636
THR A 638
PRO A 635
 None
 0.73A 1unjF-3ikmA:
undetectable		 1unjF-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 638
PRO A 635
THR A 636
 None
 0.62A 1unjL-3ikmA:
undetectable		 1unjL-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 636
THR A 638
PRO A 635
 None
 0.68A 1unjL-3ikmA:
undetectable		 1unjL-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 638
PRO A 635
THR A 636
 None
 0.63A 1unjR-3ikmA:
undetectable		 1unjR-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 636
THR A 638
PRO A 635
 None
 0.65A 1unjR-3ikmA:
undetectable		 1unjR-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 636
THR A 638
PRO A 635
 None
 0.66A 1unjW-3ikmA:
undetectable		 1unjW-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 638
PRO A 635
THR A 636
 None
 0.61A 1unjX-3ikmA:
undetectable		 1unjX-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 636
THR A 638
PRO A 635
 None
 0.66A 1unjX-3ikmA:
undetectable		 1unjX-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 638
PRO A 635
THR A 636
 None
 0.62A 1unmE-3ikmA:
undetectable		 1unmE-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 636
THR A 638
PRO A 635
 None
 0.68A 1unmE-3ikmA:
undetectable		 1unmE-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 638
PRO A 635
THR A 636
 None
 0.71A 1unmF-3ikmA:
undetectable		 1unmF-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 636
THR A 638
PRO A 635
 None
 0.69A 1unmF-3ikmA:
undetectable		 1unmF-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 12 LEU A 931
ASP A 999
LEU A 112
GLY A 111
HIS A 110
 None
 1.36A 1v8bD-3ikmA:
undetectable		 1v8bD-3ikmA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 636
THR A 638
PRO A 635
 None
 0.73A 209dC-3ikmA:
undetectable		 209dC-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 12 GLY A 928
LEU A 931
GLY A 917
ALA A 915
ALA A 899
 None
 1.06A 2bm9F-3ikmA:
undetectable		 2bm9F-3ikmA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 SER A1067
ASP A 868
CYH A1197
 None
 1.15A 2br4E-3ikmA:
undetectable		 2br4E-3ikmA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		4 / 8 ALA A 143
TRP A1118
ALA A1115
LEU A1159
 None
 0.79A 2bxmA-3ikmA:
2.2		 2bxmA-3ikmA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		4 / 6 VAL A 762
LEU A 752
PHE A 750
HIS A 733
 None
 1.34A 2f8dA-3ikmA:
0.9		 2f8dA-3ikmA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 ALA A 880
VAL A 878
TRP A 441
 None
 0.99A 2izqA-3ikmA:
undetectable
2izqB-3ikmA:
undetectable		 2izqA-3ikmA:
1.98
2izqB-3ikmA:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		4 / 7 GLY A 848
TRP A1099
MET A 299
SER A 305
 None
 1.26A 2o5yH-3ikmA:
undetectable
2o5yL-3ikmA:
undetectable		 2o5yH-3ikmA:
10.56
2o5yL-3ikmA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 12 LEU A 841
ILE A 278
ALA A 839
PHE A 291
ARG A1128
 None
 1.13A 2qo4A-3ikmA:
undetectable		 2qo4A-3ikmA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 12 LEU A 841
ILE A 278
ALA A 839
PHE A 291
ARG A1128
 None
 1.12A 2qo6A-3ikmA:
undetectable		 2qo6A-3ikmA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 LYS A1090
ARG A1047
VAL A1044
 None
 0.86A 2r2vC-3ikmA:
undetectable
2r2vD-3ikmA:
undetectable		 2r2vC-3ikmA:
3.00
2r2vD-3ikmA:
3.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		4 / 8 LEU A 466
LEU A 602
LYS A 601
ALA A 604
 None
 0.99A 2wekA-3ikmA:
undetectable		 2wekA-3ikmA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		4 / 6 ARG A1234
ILE A1155
LEU A1159
GLU A  85
 None
 1.07A 2ya7D-3ikmA:
undetectable		 2ya7D-3ikmA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 638
PRO A 635
THR A 636
 None
 0.71A 316dC-3ikmA:
undetectable		 316dC-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 12 LEU A 931
ASP A 999
LEU A 112
GLY A 111
HIS A 110
 None
 1.36A 3ce6A-3ikmA:
undetectable		 3ce6A-3ikmA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 TRP A 441
ALA A 880
VAL A 878
 None
 0.93A 3l8lA-3ikmA:
undetectable
3l8lB-3ikmA:
undetectable		 3l8lA-3ikmA:
1.98
3l8lB-3ikmA:
3.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_A_SALA1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 9 LEU A 435
SER A 433
PHE A1129
VAL A 844
LEU A 860
 None
 1.46A 3unaA-3ikmA:
undetectable		 3unaA-3ikmA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 9 LEU A 435
SER A 433
PHE A1129
VAL A 844
LEU A 860
 None
 1.46A 3unaB-3ikmA:
0.1		 3unaB-3ikmA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_A_SALA1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 9 LEU A 435
SER A 433
PHE A1129
VAL A 844
LEU A 860
 None
 1.46A 3uncA-3ikmA:
undetectable		 3uncA-3ikmA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_B_SALB1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 9 LEU A 435
SER A 433
PHE A1129
VAL A 844
LEU A 860
 None
 1.46A 3uncB-3ikmA:
0.6		 3uncB-3ikmA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		4 / 8 LEU A1025
LEU A 304
GLY A 303
VAL A 361
 None
 0.83A 4c9nA-3ikmA:
undetectable		 4c9nA-3ikmA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		4 / 7 PRO A 209
GLY A 252
ALA A 276
GLU A 280
 None
 0.90A 4g0uB-3ikmA:
undetectable		 4g0uB-3ikmA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		4 / 6 PRO A 209
GLY A 252
ALA A 276
GLU A 280
 None
 1.03A 4g0uA-3ikmA:
undetectable		 4g0uA-3ikmA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 THR A 638
PRO A 635
THR A 636
 None
 0.67A 4hivD-3ikmA:
undetectable		 4hivD-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		4 / 7 ARG A 288
SER A 296
VAL A 432
MET A 427
 None
 1.32A 4kmmA-3ikmA:
undetectable		 4kmmA-3ikmA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		4 / 6 SER A1021
GLU A1016
THR A 851
ARG A 852
 None
 1.32A 4lnxA-3ikmA:
undetectable		 4lnxA-3ikmA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 12 ALA A 604
GLY A 714
GLN A 667
GLY A 664
LEU A 612
 None
 1.09A 4uilH-3ikmA:
undetectable
4uilL-3ikmA:
undetectable		 4uilH-3ikmA:
11.78
4uilL-3ikmA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 10 PHE A 273
GLY A 431
PHE A 291
ASP A 274
ALA A 276
 None
 1.14A 4wnuD-3ikmA:
0.5		 4wnuD-3ikmA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 12 LEU A 428
LEU A 411
ALA A 847
SER A 296
VAL A 266
 None
 1.04A 4wnwB-3ikmA:
undetectable		 4wnwB-3ikmA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		4 / 7 ALA A 402
THR A 403
VAL A 406
GLU A 372
 None
 0.82A 5ecoD-3ikmA:
2.6		 5ecoD-3ikmA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		4 / 6 GLU A1090
LEU A1025
ARG A1096
ARG A1030
 None
 1.27A 5l6eA-3ikmA:
undetectable
5l6eB-3ikmA:
undetectable		 5l6eA-3ikmA:
11.49
5l6eB-3ikmA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 12 ILE A 954
TYR A 951
GLY A 952
VAL A1074
ALA A 899
 None
 1.07A 5n0oA-3ikmA:
undetectable		 5n0oA-3ikmA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 12 ILE A 954
TYR A 951
GLY A 952
VAL A1074
ALA A 899
 None
 1.06A 5n0rA-3ikmA:
undetectable		 5n0rA-3ikmA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 12 ILE A 954
TYR A 951
GLY A 952
VAL A1074
ALA A 899
 None
 1.07A 5n0wA-3ikmA:
undetectable		 5n0wA-3ikmA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		4 / 6 GLY A 928
ASP A 930
SER A 933
ARG A 943
 None
 1.19A 6dwdA-3ikmA:
undetectable
6dwdC-3ikmA:
2.1		 6dwdA-3ikmA:
17.55
6dwdC-3ikmA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 11 ALA A 425
LEU A 428
VAL A 266
ALA A 153
LEU A 151
 None
 1.26A 6h1lB-3ikmA:
undetectable		 6h1lB-3ikmA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		4 / 7 HIS A 404
THR A 403
ARG A 275
ASP A 293
 None
 1.11A 6mn4E-3ikmA:
undetectable		 6mn4E-3ikmA:
13.10