SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3il2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 3il2 REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX
(Thermus
thermophilus) 		4 / 6 PRO A 134
LEU A 160
ARG A 136
GLY A 109
 None
 1.10A 2hs2B-3il2A:
undetectable		 2hs2B-3il2A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)		 3il2 REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX
(Thermus
thermophilus) 		5 / 12 LEU A 145
ALA A  96
ILE A 127
GLY A 125
ILE A  85
 None
 1.18A 2o4lA-3il2A:
undetectable		 2o4lA-3il2A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 3il2 REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX
(Thermus
thermophilus) 		5 / 11 LEU A 145
ALA A  96
ILE A 127
GLY A 125
ILE A  85
 None
 1.31A 3oxxB-3il2A:
undetectable		 3oxxB-3il2A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 3il2 REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX
(Thermus
thermophilus) 		5 / 12 GLY A  87
GLY A  92
THR A 147
LEU A 146
VAL A 130
 None
 1.12A 4f84A-3il2A:
undetectable		 4f84A-3il2A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 3il2 REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX
(Thermus
thermophilus) 		4 / 5 ARG A 140
ARG A 108
ILE A 141
GLU A 142
 None
 1.34A 4zzcC-3il2A:
0.0
4zzcD-3il2A:
0.0		 4zzcC-3il2A:
22.69
4zzcD-3il2A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_D_ACTD401_0
(PROTON-GATED ION
CHANNEL)		 3il2 REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX
(Thermus
thermophilus) 		4 / 5 ARG A 140
ARG A 108
ILE A 141
GLU A 142
 None
 1.34A 4zzcD-3il2A:
0.0
4zzcE-3il2A:
0.0		 4zzcD-3il2A:
22.69
4zzcE-3il2A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 3il2 REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX
(Thermus
thermophilus) 		3 / 3 GLU A  22
HIS A  27
VAL A  64
 None
 0.83A 5trqB-3il2A:
undetectable		 5trqB-3il2A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3il2 REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX
(Thermus
thermophilus) 		5 / 12 ASP A 112
ILE A  85
GLY A  92
LYS A 117
LEU A 146
 None
 1.14A 5twjC-3il2A:
undetectable		 5twjC-3il2A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHG_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3il2 REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX
(Thermus
thermophilus) 		4 / 4 ARG A  46
GLN A  33
PHE A  43
LEU A  37
 None
 1.46A 5uhgC-3il2A:
0.0		 5uhgC-3il2A:
10.90