SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3il4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		4 / 7 PHE A 224
SER A 232
ALA A 227
PHE A 312
 None
 1.00A 1fxvA-3il4A:
undetectable
1fxvB-3il4A:
undetectable		 1fxvA-3il4A:
21.23
1fxvB-3il4A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		5 / 11 LEU A 322
PHE A 226
ALA A 227
VAL A 239
LEU A 247
 None
 1.07A 1hbpA-3il4A:
undetectable		 1hbpA-3il4A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		5 / 12 LEU A 322
PHE A 226
ALA A 227
VAL A 239
LEU A 247
 None
 1.14A 1rbpA-3il4A:
undetectable		 1rbpA-3il4A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		4 / 7 ILE A 286
LEU A 290
VAL A 169
GLY A 168
 None
None
CSO  A  13 ( 3.6A)
None
 0.78A 2wd9A-3il4A:
undetectable		 2wd9A-3il4A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		5 / 10 THR A 281
ILE A 286
LEU A 290
VAL A 169
GLY A 168
 None
None
None
CSO  A  13 ( 3.6A)
None
 1.27A 2wd9C-3il4A:
undetectable		 2wd9C-3il4A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		4 / 6 LEU A 301
ARG A  10
ILE A  11
LEU A 247
 None
 0.91A 2xkwB-3il4A:
undetectable		 2xkwB-3il4A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		4 / 5 LEU A 301
THR A  14
THR A 324
HIS A 178
 None
CSO  A  13 ( 3.6A)
None
None
 1.31A 2zj0B-3il4A:
2.1		 2zj0B-3il4A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		4 / 5 LEU A 301
THR A  14
THR A 324
HIS A 178
 None
CSO  A  13 ( 3.6A)
None
None
 1.37A 2zj0C-3il4A:
undetectable		 2zj0C-3il4A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		5 / 12 GLY A 119
ALA A 283
ILE A 288
GLY A 168
THR A  56
 None
 0.91A 3el4A-3il4A:
undetectable		 3el4A-3il4A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		5 / 10 GLY A 119
ALA A 283
ILE A 288
GLY A 168
THR A  56
 None
 0.98A 3el9B-3il4A:
undetectable		 3el9B-3il4A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		5 / 12 ILE A  39
ILE A  45
GLY A 163
PHE A 147
LEU A 216
 None
 1.17A 3em0B-3il4A:
1.4		 3em0B-3il4A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O01_B_DXCB1_0
(CELL INVASION
PROTEIN SIPD)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		5 / 9 ARG A  10
ILE A  11
ALA A   9
LEU A 124
VAL A 131
 None
 1.15A 3o01A-3il4A:
undetectable
3o01B-3il4A:
undetectable		 3o01A-3il4A:
24.07
3o01B-3il4A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		5 / 10 ARG A  10
ILE A  11
ALA A   9
LEU A 124
VAL A 131
 None
 1.16A 3o02A-3il4A:
undetectable
3o02B-3il4A:
undetectable		 3o02A-3il4A:
23.26
3o02B-3il4A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		5 / 12 GLY A 165
ILE A 288
GLY A 163
PHE A 147
ASN A 280
 None
None
None
None
ACO  A 401 (-3.1A)
 1.22A 3ps9A-3il4A:
undetectable		 3ps9A-3il4A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		5 / 12 LEU A 238
PHE A 179
LEU A 323
GLY A 319
PHE A 120
 None
 1.29A 3tbgC-3il4A:
undetectable		 3tbgC-3il4A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		5 / 12 ALA A  64
ILE A  81
GLY A 168
VAL A  95
VAL A  99
 None
 1.05A 3ucbA-3il4A:
undetectable		 3ucbA-3il4A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		5 / 12 LEU A 309
ILE A 286
GLY A 143
PHE A 120
ILE A 288
 None
 0.94A 3uwlB-3il4A:
undetectable		 3uwlB-3il4A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE505_1
(HEMOLYTIC LECTIN
CEL-III)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		4 / 5 ASP A  79
GLU A 107
TYR A 136
GLN A 137
 None
 1.43A 3w9tE-3il4A:
undetectable		 3w9tE-3il4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		4 / 5 ASP A  79
GLU A 107
TYR A 136
GLN A 137
 None
 1.49A 3w9tG-3il4A:
undetectable		 3w9tG-3il4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		4 / 6 LEU A 124
TYR A 122
LEU A 321
GLU A 182
 None
 1.03A 4f3tA-3il4A:
2.1		 4f3tA-3il4A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_B_ERYB501_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		5 / 11 TRP A 153
ILE A  45
ASN A  25
ALA A 252
SER A 253
 None
None
None
ACO  A 401 (-3.5A)
None
 1.49A 4m83B-3il4A:
undetectable		 4m83B-3il4A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		4 / 6 ILE A 288
ARG A  49
GLY A 163
VAL A  51
 None
CSO  A  22 ( 4.5A)
None
None
 1.06A 4oltA-3il4A:
undetectable		 4oltA-3il4A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		4 / 6 ILE A 288
ARG A  49
GLY A 163
VAL A  51
 None
CSO  A  22 ( 4.5A)
None
None
 1.05A 4oltB-3il4A:
undetectable		 4oltB-3il4A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		6 / 12 VAL A  18
GLY A 168
GLY A 143
ILE A 288
LEU A 140
VAL A  63
 None
 1.41A 4qdjA-3il4A:
undetectable		 4qdjA-3il4A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		5 / 12 GLY A 143
GLY A 168
LEU A 140
ILE A 286
ALA A  84
 None
 1.09A 4qtuB-3il4A:
3.0		 4qtuB-3il4A:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		5 / 9 PHE A 120
LEU A 309
SER A 285
VAL A  63
VAL A 169
 None
None
None
None
CSO  A  13 ( 3.6A)
 1.32A 4wnvA-3il4A:
undetectable		 4wnvA-3il4A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_B_QI9B602_0
(CYTOCHROME P450 2D6)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		5 / 9 PHE A 120
LEU A 309
SER A 285
VAL A  63
VAL A 169
 None
None
None
None
CSO  A  13 ( 3.6A)
 1.31A 4wnvB-3il4A:
undetectable		 4wnvB-3il4A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_C_QI9C602_0
(CYTOCHROME P450 2D6)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		5 / 9 PHE A 120
LEU A 309
SER A 285
VAL A  63
VAL A 169
 None
None
None
None
CSO  A  13 ( 3.6A)
 1.31A 4wnvC-3il4A:
0.1		 4wnvC-3il4A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		4 / 6 TYR A 278
ILE A  50
VAL A  18
ASP A 164
 None
 0.70A 5cu6A-3il4A:
undetectable		 5cu6A-3il4A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		3 / 3 GLU A  37
TRP A  38
ASN A  25
 None
ACO  A 401 (-3.6A)
None
 1.14A 5dv4A-3il4A:
undetectable		 5dv4A-3il4A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		5 / 9 LEU A 124
ALA A 123
PHE A 120
VAL A 169
ILE A 171
 None
None
None
CSO  A  13 ( 3.6A)
None
 1.18A 5om2A-3il4A:
undetectable
5om2B-3il4A:
undetectable		 5om2A-3il4A:
12.10
5om2B-3il4A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		4 / 7 TYR A 278
ILE A  50
VAL A  18
ASP A 164
 None
 0.69A 5ospA-3il4A:
undetectable		 5ospA-3il4A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		4 / 7 TYR A 278
ILE A  50
VAL A  18
ASP A 164
 None
 0.68A 5osrA-3il4A:
undetectable		 5osrA-3il4A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Enterococcus
faecalis) 		5 / 9 ALA A 284
SER A 285
ALA A  84
GLY A 144
ALA A 116
 None
 1.22A 6bklE-3il4A:
undetectable
6bklF-3il4A:
undetectable
6bklG-3il4A:
undetectable
6bklH-3il4A:
undetectable		 6bklE-3il4A:
5.96
6bklF-3il4A:
5.96
6bklG-3il4A:
5.96
6bklH-3il4A:
5.96